Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 / 其他抑制剂/激动剂 /
其他
HPPD
/ Nitisinone

尼替西农 /Nitisinone {[allProObj[0].p_purity_real_show]}

货号：A384235 同义名： NTBC;Nitisone

Nitisinone is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.

Nitisinone 化学结构 CAS号：104206-65-7
Nitisinone 化学结构
CAS号：104206-65-7
Nitisinone 3D分子结构
CAS号：104206-65-7
Nitisinone 化学结构 CAS号：104206-65-7
Nitisinone 3D分子结构 CAS号：104206-65-7
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Nitisinone 纯度/质量文件 产品仅供科研

货号：A384235 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell, 2024, 101755. Ambeed. [ A399663 ]
• EMBO J., 2024. Ambeed. [ A295334 ]
• JMC, 2024. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]
• JMC, 2024. Ambeed. [ A210558 , A1518164 ]
• Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]
更多 >

Nitisinone 生物活性

描述 Nitisinone is an orally active, competitive, and reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) with an IC50 of 173 nM. It increases tyrosine levels in a dose-dependent manner and is utilized in research related to hereditary tyrosinemia type 1 (HT-1), a rare genetic disorder, and albinism[1].[2].[3].[4].
体内研究

Administered orally at doses of 5 and 10 mg/kg, five days a week for six weeks, Nitisinone consistently inhibits 4-HPPD in rat liver in both a dose- and time-dependent manner[2].

Nitisinone, at a dose of 4 mg/kg administered orally once daily with a day's interval for a month, increases tyrosine levels in both OCA-1A and OCA-1B models[3].

The same dosing regimen of Nitisinone (4 mg/kg; orally; once daily; one day interval for one month) also enhances coat and iris pigmentation and increases melanin content in the melanosomes of ocular tissues in a mouse model of OCA-1B[3].
体外研究

Nitisinone (ranging from 0.01 to 10 μM over 72 hours) enhances tyrosine accumulation in a dose-responsive manner[1].

Nitisinone 参考文献

[1]Laschi M, et al. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria. ChemMedChem. 2016 Apr 5;11(7):674-8.

[2]Ellis MK, et al. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione. Toxicol Appl Pharmacol. 1995 Jul;133(1):12-9.

[3]Onojafe IF, et al. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. J Clin Invest. 2011 Oct;121(10):3914-23.

[4]Aktuglu-Zeybek A, et al. Nitisinone: a review. Orphan Drugs: Research and Reviews, 2017, 7.

Nitisinone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.19mL

3.04mL

1.52mL

30.37mL

6.07mL

3.04mL

Nitisinone 技术信息

CAS号104206-65-7
分子式C14H10F3NO5
分子量 329.23
别名 NTBC;Nitisone;brand name: Orfadin.;SC0735
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 40 mg/mL(121.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 2.7 mg/mL clear

PO 0.5% CMC-Na 50 mg/mL suspension

Tags: Nitisinone | NTBC;Nitisone;brand name: Orfadin.;SC0735 | HPPD | AmBeed-信号通路专用抑制剂 | Nitisinone 纯度/质量文件 | Nitisinone 生物活性 | Nitisinone 参考文献 | Nitisinone 实验方案 | Nitisinone 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z