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Diphenhydramine HCl

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Chemical Structure| 147-24-0 同义名 : Diphenhydramine (hydrochloride);DPH;Difenhydramine;Diphenhydramine hydrochloride
CAS号 : 147-24-0
货号 : A884689
分子式 : C17H22ClNO
纯度 : 99%
分子量 : 291.81
MDL号 : MFCD00012479
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(359.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(342.68 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • H1 receptor
描述 Diphenhydramine (DPH) Hydrochloride is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. Subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access[3]. IV administration of diphenhydramine prior to MCT (mast cell tumor) excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs[4]. Intravenous diphenhydramine hydrochloride given before initiation of midazolam and pethidine offers a significant Improvement of quality of moderate sedation during colonoscopy without increasing the number of sedation related complications[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.13mL

3.43mL

1.71mL

34.27mL

6.85mL

3.43mL
参考文献

[1]Jangi SM, Asumendi A, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72.

[2]Kim YS, Shin YK, et al. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res. 2000 Oct 27;881(2):190-8.

[3]Chen A, Loquias EJ, Roshan R, Levene R, Zelhof R, Hickey T, Cooney GA, Gonzalez F. Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. Am J Hosp Palliat Care. 2017 Dec;34(10):954-957

[4]Sanchez A, Valverde A, Sinclair M, Mosley C, Singh A, Mutsaers AJ, Hanna B, Johnson R, Gu Y, Beaudoin-Kimble M. Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors. J Am Vet Med Assoc. 2017 Oct 1;251(7):804-813

[5]El Shahawy MS, El-Fayoumy M. The Influence of Adding Diphenhydramine Before Initiation of Moderate Sedation with Midazolam and Pethidine for Improving Quality of Colonoscopy. J Natl Med Assoc. 2019 Dec;111(6):648-655