生物活性 | |||
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描述 | Diphenhydramine (DPH) Hydrochloride is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. Subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access[3]. IV administration of diphenhydramine prior to MCT (mast cell tumor) excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs[4]. Intravenous diphenhydramine hydrochloride given before initiation of midazolam and pethidine offers a significant Improvement of quality of moderate sedation during colonoscopy without increasing the number of sedation related complications[5]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.43mL 0.69mL 0.34mL |
17.13mL 3.43mL 1.71mL |
34.27mL 6.85mL 3.43mL |
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