Cordycepin | 3'-Deoxyadenosine;NSC 63984;9(3DeoxyDribofuranosyl)adenine;3Deoxyadenosine;NSC 401022 | 虫草素（3'-脱氧腺苷） | Plant Standard | Nucleoside | DNA/RNA Synthesis

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虫草素 /Cordycepin {[allProObj[0].p_purity_real_show]}

货号：A210754 同义名： 虫草素（3'-脱氧腺苷） / 3'-Deoxyadenosine;NSC 63984

Cordycepin is a nucleoside adenosine derivative that acts as an anticancer and antifungal agent. Cordycepin inhibits growth of various tumor cells in vitro. It can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Cordycepin is also useful for the study of messenger RNA transcription.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Cordycepin 化学结构
CAS号：73-03-0

Cordycepin 3D分子结构
CAS号：73-03-0

规格	价格	会员价	库存	数量
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Cordycepin 纯度/质量文件产品仅供科研

货号：A210754 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				97%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, Kd: 42.1 nM Leucyl-tRNA synthetase, IC50: 46.11 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cordycepin 生物活性

描述

Cordycepin (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological activities, such as anti-cancer, anti-inflammatory and anti-infection activities. Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs(RA synovial fibroblasts) ^[3]. Co-use of cordycepin and deoxycoformycin, an inhibitor of adenosine deaminase (ADD), more efficiently kills M. bovis and M. tuberculosis. The add-deleted mycobacterium is more sensitive to cordycepin^[4]. Cordycepin can induce apoptosis, resist cell cycle and cause DNA damage in cancer cells, and thus kill or control cancer cell growth. Also cordycepin can induce autophagy and modulate immune system. Furthermore, cordycepin also inhibits tumor metastasis^[5]. Cordycepin inhibited the nuclear translocation of P65 by preventing p‑IκBα(NF‑κB inhibitor α) activation; this resulted in the downregulation of CXCR4 (C‑X‑C chemokine receptor type 4) expression, and subsequently, in the impaired migration and invasion abilities of liver cancer cells and attenuated reactivity to SDF1(stromal cell‑derived factor 1) ^[6].

Cordycepin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00667329	Lymphoma	Phase 1	Active, not recruiting	July 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00483067	Leukemia	Phase 2	Completed	-	United States, Texas ... 展开 >> U.T.M.D. Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00412594	Leukemia	Phase 2	Recruiting	June 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 收起 <<

Cordycepin 参考文献

[1]Kodama EN, McCaffrey RP, et al. Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem Pharmacol. 2000 Feb 1;59(3):273-81.

[2]Sugar AM, McCaffrey RP. Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob Agents Chemother. 1998 Jun;42(6):1424-7.

[3]Noh EM, Kim JS, Hur H, Park BH, Song EK, Han MK, Kwon KB, Yoo WH, Shim IK, Lee SJ, Youn HJ, Lee YR. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8

[4]Huang F, Li W, Xu H, Qin H, He ZG. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. PLoS One. 2019 Jun 14;14(6):e0218449

[5]Khan MA, Tania M. Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects. Curr Med Chem. 2020;27(6):983-996

[6]Guo Z, Chen W, Dai G, Huang Y. Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med. 2020 Jan;45(1):141-150

Cordycepin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.98mL

0.80mL

0.40mL

19.90mL

3.98mL

1.99mL

39.80mL

7.96mL

3.98mL

Cordycepin 技术信息

CAS号	73-03-0
分子式	C₁₀H₁₃N₅O₃
分子量	251.242

别名	虫草素（3'-脱氧腺苷） ;3'-Deoxyadenosine;NSC 63984;9(3DeoxyDribofuranosyl)adenine;3Deoxyadenosine;NSC 401022
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 35 mg/mL(139.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 2 mg/mL(7.96 mM)，配合低频超声，并水浴加热至45℃助溶

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00667329	Lymphoma	Phase 1	Active, not recruiting	July 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00483067	Leukemia	Phase 2	Completed	-	United States, Texas ... 展开 >> U.T.M.D. Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT00412594	Leukemia	Phase 2	Recruiting	June 2019	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 收起 <<
NCT00656812	Lymphoma of Mucosa-Associated ... 展开 >>Lymphoid Tissue 收起 <<	Phase 2	Completed	-	Austria ... 展开 >> Universitätsklinikum Graz Graz, Austria, A-8036 Universitaetsklinik Innsbruck/ Klinik für Innere Medizin Innsbruck, Austria, A-6020 Krankenhaus der Stadt Linz Linz, Austria, A-4020 Universitaetsklinik f. Innere Medizin III Salzburg, Austria, A-5020 AKH Wien / Universitaetsklinik fuer Innere Medizin I Vienna, Austria, A-1090 收起 <<
NCT02157181	Hairy Cell Leukemia (HCL)	Phase 2	Completed	-	Germany ... 展开 >> Community based hemato-oncology medical office Ansbach, Germany, 91522 Community based hemato-oncology medical office Aschaffenburg, Germany, 63739 Community based hemato-oncology medical office Celle, Germany, 29221 St.-Johannes-Hospital Dortmund, Germany, 44137 Städtische Kliniken Esslingen Esslingen, Germany, 73728 Universitätsklinik Frankfurt Frankfurt am Main, Germany, 60596 Universitätsklinik Freiburg Freiburg, Germany, 79106 Community based hemato-oncology medical office Fürth, Germany, 90766 University Clinic \| Med. Cinic IV Justus-Liebig-University Gießen, Germany, 3592 Wilhelm-Anton-Hospital Goch, Germany, 47574 Kath. Krankenhaus Hagen gem. GmbH Hagen, Germany, 58095 Community based hemato-oncology medical office Halle, Germany, 06108 Community based hemato-oncology medical office Hamburg, Germany, 21073 Meditinische Hochschule (MHH) Hannover, Germany, 30623 Community based hemato-oncology medical office Heidelberg, Germany, 69115 Marienhospital Herne/ Klinikum der Ruhr-Universität Bochum Herne, Germany, 44625 Community based hemato-oncology medical office Hilden, Germany, 40721 Community based hemato-oncology medical office Hildesheim, Germany, 31134 Klinikum Idar-Oberstein Idar-Oberstein, Germany, 55743 Community based hemato-oncology medical office Jena, Germany, 07743 Community based hemato-oncology medical office Kassel, Germany, 34125 Community based hemato-oncology medical office Kiel, Germany, 24105 Community based hemato-oncology medical office Koblenz, Germany, 56068 Community based hemato-oncology medical office Kronach, Germany, 96317 Community based hemato-oncology medical office Leer, Germany, 26789 Community based hemato-oncology medical office Leipzig, Germany, 04103 Städtische Kliniken Leverkusen, Germany, 51375 Community based hemato-oncology medical office Magdeburg, Germany, 39104 Community based hemato-oncology medical office Marburg, Germany, 35037 Klinik Schwäbisch Gmünd / Staufer Klinik Mutlangen, Germany, 73557 Community based hemato-oncology medical office München, Germany, 80335 Community based hemato-oncology medical office München, Germany, 81241 Klinikum Großhadern München, Germany, 81377 Community based hemato-oncology medical office Neunkirchen, Germany, 66538 Community based hemato-oncology medical office Neuwied, Germany, 56564 Community based hemato-oncology medical office Niddatal, Germany, 61194 Community based hemato-oncology medical office Nürnberg, Germany, 90449 MVZ Klinikum Osnabrück Osnabrück, Germany, 49076 Community based hemato-oncology medical office Pforzheim, Germany, 75179 Klinikum Ernst von Bergmann gGmbH Potsdam, Germany, 14467 St. Josefs-Krankenhaus Potsdam, Germany, 14471 Community based hemato-oncology medical office Schweinfurt, Germany, 97421 St. Marien-Krankenhaus Siegen, Germany, 57072 Community based hemato-oncology medical office Straubing, Germany, 94315 Diakonie-Klinikum Stuttgart Stuttgart, Germany, 70176 Community based hemato-oncology medical office Villingen, Germany, 78050 Community based hemato-oncology medical office Wolfsburg, Germany, 38440 收起 <<
NCT00709215	Refractory TdT-Positive Leukem... 展开 >>ia 收起 <<	Phase 1 Phase 2	Unknown	December 2010	United States, Massachusetts ... 展开 >> Brigham & Women's Hospital Recruiting Boston, Massachusetts, United States, 02115 Dana Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02115 Contact: Daniel J DeAngelo, MD, PhD. 617-632-2645 Daniel_Deangelo@dfci.harvard.edu Principal Investigator: Daneil J DeAngelo, MD, PhD. Sub-Investigator: Richard Stone, MD Sub-Investigator: L. Andres Sirulnik, MD Sub-Investigator: Martha Wadleigh, MD Sub-Investigator: Gregory Abel, MD, MPH Sub-Investigator: Susan L Buchanan, PA Sub-Investigator: Adriana Penicaud, PA Sub-Investigator: Ilene Galinsky, APRN Sub-Investigator: Eyal Attar, MD Sub-Investigator: Philip Amrein, MD Sub-Investigator: Karen Kuhn Ballen, MD United States, Texas Cancer Therapy Reasearch Center at UTHSCA Recruiting San Antonio, Texas, United States, 78229 Contact: Swaminathan Padmanabhan, MD 210-450-5094 PadmanabhanS@uthscsa.edu Sub-Investigator: Monica Mita, MD Principal Investigator: Alain Mita, MD 收起 <<
NCT00003005	Leukemia	Phase 1	Completed	-	United States, District of Col... 展开 >>umbia Vincent T. Lombardi Cancer Research Center, Georgetown University Washington, District of Columbia, United States, 20007 United States, Maryland Johns Hopkins Oncology Center Baltimore, Maryland, United States, 21287 United States, Massachusetts New England Medical Center Hospital Boston, Massachusetts, United States, 02111 Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Boston Medical Center Boston, Massachusetts, United States, 02118 University of Massachusetts Memorial Medical Center Worcester, Massachusetts, United States, 01655 United States, Missouri Washington University Barnard Cancer Center Saint Louis, Missouri, United States, 63110 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263-0001 United States, North Carolina Lineberger Comprehensive Cancer Center, UNC Chapel Hill, North Carolina, United States, 27599-7295 United States, Ohio Arthur G. James Cancer Hospital - Ohio State University Columbus, Ohio, United States, 43210 United States, Oregon Oregon Cancer Center at Oregon Health Sciences University Portland, Oregon, United States, 97201-3098 收起 <<

虫草素 /Cordycepin {[allProObj[0].p_purity_real_show]}

Cordycepin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Cordycepin 质控信息

Cordycepin 生物活性

Cordycepin 临床研究

Cordycepin 参考文献

Cordycepin 实验方案

Cordycepin 技术信息

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虫草素 /Cordycepin {[allProObj[0].p_purity_real_show]}

Cordycepin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Cordycepin 质控信息

Cordycepin 生物活性

Cordycepin 临床研究

Cordycepin 参考文献

Cordycepin 实验方案

Cordycepin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Cordycepin 纯度/质量文件产品仅供科研