产品说明书
Cordycepin
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同义名 : | 虫草素（3'-脱氧腺苷） ;3'-Deoxyadenosine;NSC 63984;9(3DeoxyDribofuranosyl)adenine;3Deoxyadenosine;NSC 401022 |
| CAS号 : | 73-03-0 | |
| 货号 : | A210754 | |
| 分子式 : | C10H13N5O3 | |
| 纯度 : | 98% | |
| 分子量 : | 251.242 | |
| MDL号 : | MFCD00037998 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 35 mg/mL(139.31 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2 mg/mL(7.96 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Cordycepin (3'-deoxyadenosine), a bioactive compound of Cordyceps militaris, has been shown to exhibit many pharmacological activities, such as anti-cancer, anti-inflammatory and anti-infection activities. Cordycepin is a potent inhibitor of IL-1beta-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs(RA synovial fibroblasts) [3]. Co-use of cordycepin and deoxycoformycin, an inhibitor of adenosine deaminase (ADD), more efficiently kills M. bovis and M. tuberculosis. The add-deleted mycobacterium is more sensitive to cordycepin[4]. Cordycepin can induce apoptosis, resist cell cycle and cause DNA damage in cancer cells, and thus kill or control cancer cell growth. Also cordycepin can induce autophagy and modulate immune system. Furthermore, cordycepin also inhibits tumor metastasis[5]. Cordycepin inhibited the nuclear translocation of P65 by preventing p‑IκBα(NF‑κB inhibitor α) activation; this resulted in the downregulation of CXCR4 (C‑X‑C chemokine receptor type 4) expression, and subsequently, in the impaired migration and invasion abilities of liver cancer cells and attenuated reactivity to SDF1(stromal cell‑derived factor 1) [6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00667329 | Lymphoma | Phase 1 | Active, not recruiting | July 2019 | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
| NCT00483067 | Leukemia | Phase 2 | Completed | - | United States, Texas ... 展开 >> U.T.M.D. Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
| NCT00412594 | Leukemia | Phase 2 | Recruiting | June 2019 | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.98mL 0.80mL 0.40mL |
19.90mL 3.98mL 1.99mL |
39.80mL 7.96mL 3.98mL |
| 参考文献 |
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