盐酸倍他司汀 /Betahistine 2HCl
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货号：A120842
同义名：
N-甲基-2-吡啶乙胺二盐酸盐
/ Betahistine (hydrochloride);PT-9
Betahistine 2HCl is histamine H3 receptor inhibitor with IC50 of 1.9 μM. It is an antivertigo drug.
Betahistine 2HCl 化学结构
Betahistine 2HCl 3D分子结构
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Betahistine 2HCl 纯度/质量文件 产品仅供科研
货号：A120842
标准纯度：
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Betahistine 2HCl 质控信息
Hydroxyzine 2HCl
99+%
Cyclizine
✔
97%
Loratadine
+
98%
Desloratadine
++
Histamine H1 receptor, IC50: 51 nM
98%
Doxylamine succinate
✔
99%
Ebastine
✔
98%
Tripelennamine HCl
+
98%
Meclizine dihydrochloride
✔
98%
Chlorpheniramine maleate
+++
Histamine H1 receptor, IC50: 12 nM
99%
Diphenhydramine HCl
✔
99%
Alcaftadine
++++
++
99%+
Fexofenadine HCl
++
Histamine H1 receptor, IC50: 246 nM
99%+
Bilastine
+++
H1 receptor, Ki: 44.15 nM
98%
Pemirolast potassium
✔
98%
Bepotastine besilate
+
Histamine H1 receptor, pIC50: 5.7
98%
Mizolastine
+++
Histamine H1 receptor, IC50: 47 nM
98%
Brompheniramine maleate
✔
98%
Carbinoxamine maleate salt
✔
99+%
Clemastine fumarate
++++
Histamine H1 receptor, IC50: 3 nM
98%
Ketotifen fumarate salt
✔
95%
Rupatadine Fumarate
++
Histamine H1 receptor, Ki: 102 nM
PAFR
98%
Famotidine
✔
97%
Roxatidine Acetate HCl
+
Histamine H2 receptor, IC50: 3.2 μM
98%
Lafutidine
✔
99%
Cimetidine
✔
98%
Nizatidine
++++
Histamine H2 receptor, IC50: 0.9 nM
AChE
98%
Ranitidine
✔
99%
Betahistine
+
Histamine H3 receptor, IC50: 1.9 μM
98%
Ciproxifan maleate
+++
Histamine H3 receptor, IC50: 9.2 nM
99%+
S 38093
++
rat H3 receptor, Ki: 1.44 μM
human H3 receptor, Ki: 1.2 μM
98%
JNJ-7777120
++++
Histamine H4 receptor, Ki: 4.5 nM
98%
Azelastine HCl
✔
98%
Epinastine HCl
✔
98%
Levodropropizine
✔
97%
Cyproheptadine hydrochloride
✔
98%
Hesperetin
✔
97%
Olopatadine HCl
✔
98%
Mianserin hydrochloride
✔
99+%
Buclizine 2HCl
✔
97%
Latrepirdine 2HCl
✔
GluR
98%
Cetirizine 2HCl
✔
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Betahistine 2HCl 生物活性
描述
Betahistine dihydrochloride (BDH) is a histamine analog used to control weight gain, with short elimination half-life and gastric irritation as side effects. BDH ethosomal gel showed effective, sustained transdermal absorption and central action in decreasing food intake and, consequently, the weight gain[3] [4] [5]
Betahistine 2HCl 参考文献
[1] Gbahou F, Davenas E, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo. J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.
[2] Mira E, Guidetti G, et al. Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo. Eur Arch Otorhinolaryngol. 2003 Feb;260(2):73-7.
[3] El-Menshawe SF, Ali AA, Halawa AA, Srag El-Din AS. A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization. Drug Des Devel Ther. 2017 Nov 28;11:3377-3388
[4] Elkomy MH, El-Menshawe SF, Ali AA, Halawa AA, El-Din ASGS. Betahistine dihydrochloride transdermal delivery via optimized thermosensitive gels: percutaneous absorption evaluation using rat growth as a biomarker. Drug Deliv Transl Res. 2018 Feb;8(1):165-177
[5] Pilicheva BA, Kassarova MI, Zagorchev PI, Uzunova YI. Formulation and performance evaluation of betahistine dihydrochloride microspheres as sustained release systems. Folia Med (Plovdiv). 2014 Jul-Sep;56(3):187-93
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Betahistine 2HCl 实验方案
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总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.78mL
0.96mL
0.48mL
23.91mL
4.78mL
2.39mL
47.82mL
9.56mL
4.78mL
Betahistine 2HCl 技术信息
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