7-(2,3-Dihydroxypropyl)theophylline | Diprophylline | PDE Inhibitor

首页 / / / / 7-(2,3-Dihydroxypropyl)theophylline

二羟丙茶碱 /7-(2,3-Dihydroxypropyl)theophylline {[allProObj[0].p_purity_real_show]}

货号：A520792 同义名： Diprophylline;Diphylline

Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.

7-(2,3-Dihydroxypropyl)theophylline 化学结构
CAS号：479-18-5

7-(2,3-Dihydroxypropyl)theophylline 3D分子结构
CAS号：479-18-5

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件产品仅供科研

货号：A520792 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

腺苷受体亚型比较
PDE 亚型比较

产品名称	Adenosine Receptor ↓ ↑	纯度
ZM241385	✔	99%+
Istradefylline	+++ Adenosine A2A receptor, Ki: 2.2 nM	98%
Reversine	+ human A3 adenosine receptor, Ki: 0.66 μM	98%
SCH58261	++++ rat A2a, Ki: 2.3 nM bovine A2a, Ki: 2.0 nM	99%+
A2A receptor antagonist 1	++ A1R, Ki: 264 nM A2AR, Ki: 4 nM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	PDE ↓ ↑	PDE1 ↓ ↑	PDE10A ↓ ↑	PDE2 ↓ ↑	PDE3 ↓ ↑	PDE4 ↓ ↑	PDE5 ↓ ↑	PDE6 ↓ ↑	其他靶点	纯度
Doxofylline	✔									99+%
Deltarasin	+++ PDEδ , Kd: 38 nM									99+%
7-(2,3-Dihydroxypropyl)theophylline	✔									98%
Aminophylline	+ PDE, IC50: 0.12 mM									98+%
Anagrelide HCl	✔									99%+
Irsogladine	✔								AChR,mAChR	98%
PF-8380	+++ Autotaxin, IC50: 2.8 nM									99%+
Dipyridamole	✔									98%
Balipodect			++++ PDE10A, IC50: 0.3 nM							99%+
PF-2545920			++++ PDE10A, IC50: 0.37 nM							97%
Luteolin		+ PDE1, Ki: 15.0 μM		++ PDE2, Ki: 6.4 μM	+ PDE3, Ki: 13.9 μM	+ PDE4, Ki: 11.1 μM	+ PDE5, Ki: 9.5 μM			98%
Milrinone				++ PDE2, IC50: 5.2 μM	++ PDE3, IC50: 2.1 μM				ATPase	98%
Pimobendan					++ PDE3, IC50: 0.32 μM					98%
Cilostazol					++ PDE3, IC50: 0.2 μM					98%
Fenspiride HCl					+ PDE3, pIC50: 3.44	+ PDE4, pIC50: 4.16				98%
(S)-(+)-Rolipram						++ PDE4, IC50: 0.75 μM				98%
Apremilast						+++ PDE4, IC50: 74 nM				98%
GSK256066						++++ PDE4B, IC50: 3.2 pM				98+%
Roflumilast						++++ PDE4A4, IC50: 4.3 nM PDE4A1, IC50: 0.7 nM				99%
Rolipram						+++ PDE4B, IC50: 130 nM				99%+
Cilomilast						+++ HPDE4, IC50: 120 nM LPDE4, IC50: 100 nM				98+%
Avanafil							++++ PDE5, IC50: 1 nM			98%
Vardenafil HCl Trihydrate							++++ PDE5, IC50: 0.7 nM			98%
Tadalafil							++++ PDE5, IC50: 1.8 nM			98%
Icariin							++ PDE5, IC50: 0.432 μM			98%
Sildenafil							✔	+++ PDE6, IC50: 33 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

7-(2,3-Dihydroxypropyl)theophylline 生物活性

靶点	PDE
描述	Diphylline (Diprophylline) is an A1/A2 adenosine receptor antagonist and a cyclic nucleotide phosphodiesterase inhibitor. As a xanthine derivative, Diphylline acts as a bronchodilator and vasodilator and is potentially useful for treating chronic bronchitis and emphysema^[1].^[2].

7-(2,3-Dihydroxypropyl)theophylline 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00345930	-		Recruiting	July 2022	United States, California ... 展开 >> University of Southern California Recruiting Los Angeles, California, United States, 90033 Contact: Susan Milstein, RN, BSN 323-224-5441 smilstei@usc.edu Contact: None Available Principal Investigator: Andrew Stolz, MD United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202-5111 Contact: Audrey Corne, RN ,EdD 317-278-3062 acorne@iu.edu Principal Investigator: Naga P Chalasani, MD United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109-0362 Contact: Ben Johnson 734-936-4886 kendalld@med.umich.edu Principal Investigator: Robert J Fontana, MD United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Stephanie Pagan stephanie.pagan@mssm.edu Contact: Jospeph odin, MD 212-241-8035 joseph.odin@mountsinai.org United States, North Carolina Univeristy of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599-7600 Contact: Tracy Russell 919-843-2376 trussell@med.unc.edu Contact: None Available Principal Investigator: Paul B Watkins, MD United States, Pennsylvania Albert Einstein Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Manisha Verma, MD MPH 215-456-2480 VegaMari@einstein.edu Principal Investigator: Victor J Navarro, MD 收起 <<

7-(2,3-Dihydroxypropyl)theophylline 参考文献

[1]Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

[2]Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2

7-(2,3-Dihydroxypropyl)theophylline 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

7-(2,3-Dihydroxypropyl)theophylline 技术信息

CAS号	479-18-5
分子式	C₁₀H₁₄N₄O₄
分子量	254.24

别名	Diprophylline;Diphylline;Neothylline;Corphyllin;NSC 40844;NSC 14305;Neothyllin;Lufyllin;Dilor;Dyphylline
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 50 mg/mL(196.66 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 20 mg/mL(78.67 mM)，配合低频超声助溶

动物实验配方

二羟丙茶碱 /7-(2,3-Dihydroxypropyl)theophylline {[allProObj[0].p_purity_real_show]}

7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

7-(2,3-Dihydroxypropyl)theophylline 质控信息

7-(2,3-Dihydroxypropyl)theophylline 生物活性

7-(2,3-Dihydroxypropyl)theophylline 临床研究

7-(2,3-Dihydroxypropyl)theophylline 参考文献

7-(2,3-Dihydroxypropyl)theophylline 实验方案

7-(2,3-Dihydroxypropyl)theophylline 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

二羟丙茶碱 /7-(2,3-Dihydroxypropyl)theophylline {[allProObj[0].p_purity_real_show]}

7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

7-(2,3-Dihydroxypropyl)theophylline 质控信息

7-(2,3-Dihydroxypropyl)theophylline 生物活性

7-(2,3-Dihydroxypropyl)theophylline 临床研究

7-(2,3-Dihydroxypropyl)theophylline 参考文献

7-(2,3-Dihydroxypropyl)theophylline 实验方案

7-(2,3-Dihydroxypropyl)theophylline 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件产品仅供科研