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/ 7-(2,3-Dihydroxypropyl)theophylline

二羟丙茶碱 /7-(2,3-Dihydroxypropyl)theophylline {[allProObj[0].p_purity_real_show]}

货号：A520792 同义名： Diprophylline;Diphylline

Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.

7-(2,3-Dihydroxypropyl)theophylline 化学结构 CAS号：479-18-5
7-(2,3-Dihydroxypropyl)theophylline 化学结构
CAS号：479-18-5
7-(2,3-Dihydroxypropyl)theophylline 3D分子结构
CAS号：479-18-5
7-(2,3-Dihydroxypropyl)theophylline 化学结构 CAS号：479-18-5
7-(2,3-Dihydroxypropyl)theophylline 3D分子结构 CAS号：479-18-5
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7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件 产品仅供科研

货号：A520792 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Adenosine Receptor ↓ 其他靶点 纯度
ZM241385 ✔ 99%+
Istradefylline +++

Adenosine A2A receptor, Ki: 2.2 nM

 		98%
Reversine +

human A3 adenosine receptor, Ki: 0.66 μM

 		98%
SCH58261 ++++

rat A2a, Ki: 2.3 nM

bovine A2a, Ki: 2.0 nM

 		99%+
A2A receptor antagonist 1 ++

A2AR, Ki: 4 nM

A1R, Ki: 264 nM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 PDE ↓ PDE1 ↓ PDE10A ↓ PDE2 ↓ PDE3 ↓ PDE4 ↓ PDE5 ↓ PDE6 ↓ 其他靶点 纯度
Doxofylline ✔ 99+%
Deltarasin +++

PDEδ , Kd: 38 nM

 		99+%
7-(2,3-Dihydroxypropyl)theophylline ✔ 98%
Aminophylline +

PDE, IC50: 0.12 mM

 		98+%
Anagrelide HCl ✔ 99%+
Irsogladine ✔ AChR,mAChR 98%
PF-8380 +++

Autotaxin, IC50: 2.8 nM

 		99%+
Dipyridamole ✔ 98%
Balipodect ++++

PDE10A, IC50: 0.3 nM

 		99%+
PF-2545920 ++++

PDE10A, IC50: 0.37 nM

 		97%
Luteolin +

PDE1, Ki: 15.0 μM

 		++

PDE2, Ki: 6.4 μM

 		+

PDE3, Ki: 13.9 μM

 		+

PDE4, Ki: 11.1 μM

 		+

PDE5, Ki: 9.5 μM

 		98%
Milrinone ++

PDE2, IC50: 5.2 μM

 		++

PDE3, IC50: 2.1 μM

 		ATPase 98%
Pimobendan ++

PDE3, IC50: 0.32 μM

 		98%
Cilostazol ++

PDE3, IC50: 0.2 μM

 		98%
Fenspiride HCl +

PDE3, pIC50: 3.44

 		+

PDE4, pIC50: 4.16

 		98%
(S)-(+)-Rolipram ++

PDE4, IC50: 0.75 μM

 		98%
Apremilast +++

PDE4, IC50: 74 nM

 		98%
GSK256066 ++++

PDE4B, IC50: 3.2 pM

 		98+%
Roflumilast ++++

PDE4A1, IC50: 0.7 nM

PDE4A4, IC50: 4.3 nM

 		99%
Rolipram +++

PDE4B, IC50: 130 nM

 		99%+
Cilomilast +++

LPDE4, IC50: 100 nM

HPDE4, IC50: 120 nM

 		98+%
Avanafil ++++

PDE5, IC50: 1 nM

 		98%
Vardenafil HCl Trihydrate ++++

PDE5, IC50: 0.7 nM

 		98%
Tadalafil ++++

PDE5, IC50: 1.8 nM

 		98%
Icariin ++

PDE5, IC50: 0.432 μM

 		98%
Sildenafil ✔ +++

PDE6, IC50: 33 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

7-(2,3-Dihydroxypropyl)theophylline 生物活性

靶点

  • PDE
描述 Diphylline (Diprophylline) is an A1/A2 adenosine receptor antagonist and a cyclic nucleotide phosphodiesterase inhibitor. As a xanthine derivative, Diphylline acts as a bronchodilator and vasodilator and is potentially useful for treating chronic bronchitis and emphysema[1].[2].

7-(2,3-Dihydroxypropyl)theophylline 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00345930 - Recruiting July 2022 United States, California ... 展开 >> University of Southern California Recruiting Los Angeles, California, United States, 90033 Contact: Susan Milstein, RN, BSN    323-224-5441    smilstei@usc.edu    Contact: None Available          Principal Investigator: Andrew Stolz, MD          United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202-5111 Contact: Audrey Corne, RN ,EdD    317-278-3062    acorne@iu.edu    Principal Investigator: Naga P Chalasani, MD          United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109-0362 Contact: Ben Johnson    734-936-4886    kendalld@med.umich.edu    Principal Investigator: Robert J Fontana, MD          United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Stephanie Pagan       stephanie.pagan@mssm.edu    Contact: Jospeph odin, MD    212-241-8035    joseph.odin@mountsinai.org    United States, North Carolina Univeristy of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599-7600 Contact: Tracy Russell    919-843-2376    trussell@med.unc.edu    Contact: None Available          Principal Investigator: Paul B Watkins, MD          United States, Pennsylvania Albert Einstein Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Manisha Verma, MD MPH    215-456-2480    VegaMari@einstein.edu    Principal Investigator: Victor J Navarro, MD 收起 <<

7-(2,3-Dihydroxypropyl)theophylline 参考文献

[1]Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

[2]Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2

7-(2,3-Dihydroxypropyl)theophylline 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

7-(2,3-Dihydroxypropyl)theophylline 技术信息

CAS号479-18-5
分子式C10H14N4O4
分子量 254.24
别名 Diprophylline;Diphylline;Neothylline;Corphyllin;NSC 40844;NSC 14305;Neothyllin;Lufyllin;Dilor;Dyphylline
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 50 mg/mL(196.66 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(78.67 mM)，配合低频超声助溶
动物实验配方

Tags: Diphylline | 479-18-5 | Diprophylline | Adenosine Receptor | PDE Inhibitor | GPCR/G Protein | Metabolic Enzyme/Protease | Adenosine Receptor | Phosphodiesterase (PDE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 7-(2,3-Dihydroxypropyl)theophylline 纯度/质量文件 | 7-(2,3-Dihydroxypropyl)theophylline 亚型比较 | 7-(2,3-Dihydroxypropyl)theophylline 生物活性 | 7-(2,3-Dihydroxypropyl)theophylline 临床数据 | 7-(2,3-Dihydroxypropyl)theophylline 参考文献 | 7-(2,3-Dihydroxypropyl)theophylline 实验方案 | 7-(2,3-Dihydroxypropyl)theophylline 技术信息

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