货号:A520792
同义名:
Diprophylline;Diphylline
Dyphylline, a xanthine derivative, acts as an adenosine receptor antagonist and phosphodiesterase inhibitor, which is used in the treatment of respiratory disorders.
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Adenosine Receptor ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ZM241385 | ✔ | 99%+ | |||||||||||||||||
Istradefylline |
+++
Adenosine A2A receptor, Ki: 2.2 nM |
99%+ | |||||||||||||||||
Reversine |
+
human A3 adenosine receptor, Ki: 0.66 μM |
98% | |||||||||||||||||
SCH58261 |
++++
bovine A2a, Ki: 2.0 nM rat A2a, Ki: 2.3 nM |
99%+ | |||||||||||||||||
A2A receptor antagonist 1 |
++
A2AR, Ki: 4 nM A1R, Ki: 264 nM |
99%+ | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | PDE ↓ ↑ | PDE1 ↓ ↑ | PDE10A ↓ ↑ | PDE2 ↓ ↑ | PDE3 ↓ ↑ | PDE4 ↓ ↑ | PDE5 ↓ ↑ | PDE6 ↓ ↑ | 其他靶点 | 纯度 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Doxofylline | ✔ | 99+% | |||||||||||||||||
Deltarasin |
+++
PDEδ , Kd: 38 nM |
99+% | |||||||||||||||||
7-(2,3-Dihydroxypropyl)theophylline | ✔ | 99%+ | |||||||||||||||||
Aminophylline |
+
PDE, IC50: 0.12 mM |
99%+ | |||||||||||||||||
Anagrelide HCl | ✔ | 99%+ | |||||||||||||||||
Irsogladine | ✔ | mAChR,AChR | 99%+ | ||||||||||||||||
PF-8380 |
+++
Autotaxin, IC50: 2.8 nM |
99%+ | |||||||||||||||||
Dipyridamole | ✔ | 99%+ | |||||||||||||||||
Balipodect |
++++
PDE10A, IC50: 0.3 nM |
99%+ | |||||||||||||||||
PF-2545920 |
++++
PDE10A, IC50: 0.37 nM |
97% | |||||||||||||||||
Luteolin |
+
PDE1, Ki: 15.0 μM |
++
PDE2, Ki: 6.4 μM |
+
PDE3, Ki: 13.9 μM |
+
PDE4, Ki: 11.1 μM |
+
PDE5, Ki: 9.5 μM |
98% | |||||||||||||
Milrinone |
++
PDE2, IC50: 5.2 μM |
++
PDE3, IC50: 2.1 μM |
ATPase | 99%+ | |||||||||||||||
Pimobendan |
++
PDE3, IC50: 0.32 μM |
99%+ | |||||||||||||||||
Cilostazol |
++
PDE3, IC50: 0.2 μM |
99%+ | |||||||||||||||||
Fenspiride HCl |
+
PDE3, pIC50: 3.44 |
+
PDE4, pIC50: 4.16 |
99%+ | ||||||||||||||||
(S)-(+)-Rolipram |
++
PDE4, IC50: 0.75 μM |
98% | |||||||||||||||||
Apremilast |
+++
PDE4, IC50: 74 nM |
98% | |||||||||||||||||
GSK256066 |
++++
PDE4B, IC50: 3.2 pM |
98+% | |||||||||||||||||
Roflumilast |
++++
PDE4A4, IC50: 4.3 nM PDE4A1, IC50: 0.7 nM |
99% | |||||||||||||||||
Rolipram |
+++
PDE4B, IC50: 130 nM |
99%+ | |||||||||||||||||
Cilomilast |
+++
LPDE4, IC50: 100 nM HPDE4, IC50: 120 nM |
98+% | |||||||||||||||||
Avanafil |
++++
PDE5, IC50: 1 nM |
99%+ | |||||||||||||||||
Vardenafil HCl Trihydrate |
++++
PDE5, IC50: 0.7 nM |
99%+ | |||||||||||||||||
Tadalafil |
++++
PDE5, IC50: 1.8 nM |
98% | |||||||||||||||||
Icariin |
++
PDE5, IC50: 0.432 μM |
98% | |||||||||||||||||
Sildenafil | ✔ |
+++
PDE6, IC50: 33 nM |
99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Diphylline (Diprophylline) is an A1/A2 adenosine receptor antagonist and a cyclic nucleotide phosphodiesterase inhibitor. As a xanthine derivative, Diphylline acts as a bronchodilator and vasodilator and is potentially useful for treating chronic bronchitis and emphysema[1].[2]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00345930 | - | Recruiting | July 2022 | United States, California ... 展开 >> University of Southern California Recruiting Los Angeles, California, United States, 90033 Contact: Susan Milstein, RN, BSN 323-224-5441 smilstei@usc.edu Contact: None Available Principal Investigator: Andrew Stolz, MD United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202-5111 Contact: Audrey Corne, RN ,EdD 317-278-3062 acorne@iu.edu Principal Investigator: Naga P Chalasani, MD United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109-0362 Contact: Ben Johnson 734-936-4886 kendalld@med.umich.edu Principal Investigator: Robert J Fontana, MD United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Stephanie Pagan stephanie.pagan@mssm.edu Contact: Jospeph odin, MD 212-241-8035 joseph.odin@mountsinai.org United States, North Carolina Univeristy of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599-7600 Contact: Tracy Russell 919-843-2376 trussell@med.unc.edu Contact: None Available Principal Investigator: Paul B Watkins, MD United States, Pennsylvania Albert Einstein Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Manisha Verma, MD MPH 215-456-2480 VegaMari@einstein.edu Principal Investigator: Victor J Navarro, MD 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.93mL 0.79mL 0.39mL |
19.67mL 3.93mL 1.97mL |
39.33mL 7.87mL 3.93mL |
CAS号 | 479-18-5 |
分子式 | C10H14N4O4 |
分子量 | 254.24 |
别名 | Diprophylline;Diphylline;Neothylline;Corphyllin;NSC 40844;NSC 14305;Neothyllin;Lufyllin;Dilor;Dyphylline |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(196.66 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 20 mg/mL(78.67 mM),配合低频超声助溶 |
动物实验配方 |