(S)-(+)-Rolipram | S-(+)-Rolipram;(+)-Rolipram;(S)-Rolipram | Phosphodiesterase Inhibitor | PDE

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(S)-(+)-咯利普兰 /(S)-(+)-Rolipram {[allProObj[0].p_purity_real_show]}

货号：A107169 同义名： S-(+)-Rolipram;(+)-Rolipram

(S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory agent, less potent than its R-enantiomer.

(S)-(+)-Rolipram 化学结构
CAS号：85416-73-5

(S)-(+)-Rolipram 3D分子结构
CAS号：85416-73-5

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(S)-(+)-Rolipram 纯度/质量文件产品仅供科研

货号：A107169 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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PDE 亚型比较

产品名称	PDE ↓ ↑	PDE1 ↓ ↑	PDE10A ↓ ↑	PDE2 ↓ ↑	PDE3 ↓ ↑	PDE4 ↓ ↑	PDE5 ↓ ↑	PDE6 ↓ ↑	其他靶点	纯度
Doxofylline	✔									99+%
Deltarasin	+++ PDEδ , Kd: 38 nM									99+%
7-(2,3-Dihydroxypropyl)theophylline	✔									98%
Aminophylline	+ PDE, IC50: 0.12 mM									98+%
Anagrelide HCl	✔									99%+
Irsogladine	✔								AChR,mAChR	98%
PF-8380	+++ Autotaxin, IC50: 2.8 nM									99%+
Dipyridamole	✔									98%
Balipodect			++++ PDE10A, IC50: 0.3 nM							99%+
PF-2545920			++++ PDE10A, IC50: 0.37 nM							97%
Luteolin		+ PDE1, Ki: 15.0 μM		++ PDE2, Ki: 6.4 μM	+ PDE3, Ki: 13.9 μM	+ PDE4, Ki: 11.1 μM	+ PDE5, Ki: 9.5 μM			98%
Milrinone				++ PDE2, IC50: 5.2 μM	++ PDE3, IC50: 2.1 μM				ATPase	98%
Pimobendan					++ PDE3, IC50: 0.32 μM					98%
Cilostazol					++ PDE3, IC50: 0.2 μM					98%
Fenspiride HCl					+ PDE3, pIC50: 3.44	+ PDE4, pIC50: 4.16				98%
(S)-(+)-Rolipram						++ PDE4, IC50: 0.75 μM				98%
Apremilast						+++ PDE4, IC50: 74 nM				98%
GSK256066						++++ PDE4B, IC50: 3.2 pM				98+%
Roflumilast						++++ PDE4A4, IC50: 4.3 nM PDE4A1, IC50: 0.7 nM				99%
Rolipram						+++ PDE4B, IC50: 130 nM				99%+
Cilomilast						+++ LPDE4, IC50: 100 nM HPDE4, IC50: 120 nM				98+%
Avanafil							++++ PDE5, IC50: 1 nM			98%
Vardenafil HCl Trihydrate							++++ PDE5, IC50: 0.7 nM			98%
Tadalafil							++++ PDE5, IC50: 1.8 nM			98%
Icariin							++ PDE5, IC50: 0.432 μM			98%
Sildenafil							✔	+++ PDE6, IC50: 33 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(S)-(+)-Rolipram 生物活性

靶点	PDE4 PDE4, IC50:0.75 μM
描述	(S)-(+)-Rolipram, known as (+)-Rolipram, is a selective inhibitor of cyclic AMP (cAMP)-specific phosphodiesterase 4 (PDE4) with an IC50 of 1100 nM. It is effective in suppressing tumor necrosis factor-alpha (TNFα) production in human mononuclear cells^[1].^[2].^[3].
体内研究	Moreover, (+)-Rolipram (0.025-6.25 mg/kg; a single i.p. injection) reduces locomotor activity and induces head twitches in rats in a dose-dependent manner^[2]. In further studies, (+)-Rolipram (0.06-25 mg/kg; a single i.p. injection) leads to a dose-related decrease in the rectal temperature of rats^[2].
体外研究	In laboratory settings, (+)-Rolipram (0.015-1000 μM; 20 h) has shown a dose-dependent ability to inhibit LPS-induced TNF production in human mononuclear cells, with an IC50 value of 550 nM^[1].

(S)-(+)-Rolipram 参考文献

[1]Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13.

[2]Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4.

[3]Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.

(S)-(+)-Rolipram 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.63mL

0.73mL

0.36mL

18.16mL

3.63mL

1.82mL

36.32mL

7.26mL

3.63mL

(S)-(+)-Rolipram 技术信息

CAS号	85416-73-5
分子式	C₁₆H₂₁NO₃
分子量	275.343

别名	S-(+)-Rolipram;(+)-Rolipram;(S)-Rolipram
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(381.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+30% PEG300+water 7 mg/mL clear

PO 0.5% CMC-Na 47 mg/mL suspension

(S)-(+)-咯利普兰 /(S)-(+)-Rolipram {[allProObj[0].p_purity_real_show]}

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(S)-(+)-Rolipram 生物活性

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(S)-(+)-Rolipram 实验方案

(S)-(+)-Rolipram 技术信息

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(S)-(+)-咯利普兰 /(S)-(+)-Rolipram {[allProObj[0].p_purity_real_show]}

(S)-(+)-Rolipram 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

(S)-(+)-Rolipram 质控信息

(S)-(+)-Rolipram 生物活性

(S)-(+)-Rolipram 参考文献

(S)-(+)-Rolipram 实验方案

(S)-(+)-Rolipram 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

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确认信息

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