5,7-Diacetoxy-8-methoxyflavone is a natural product isolated and purified from the roots of Scutellaria baicalensis.

Lirimilast是一种有效且选择性的口服磷酸二酯酶 4 (PDE4) 抑制剂，IC₅₀ 为 49 nM，主要用于研究哮喘和慢性阻塞性肺疾病 (COPD)，具有显著的抗炎活性【183】。

N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity.

Ensifentrine is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC50s of 0.4 nM and 1479 nM, respectively.

MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase 5 with IC50 of 0.5 μM.

DSR-141562 is a novel orally available and brain-penetrant PDE 1 inhibitor. It has preferential selectivity for predominantly brain-expressed PDE1B over other PDE1 family members, and high selectivity for the PDE1 family over other PDE families and 65 other tested biologic targets.

ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

OR-1896 是 Levosimendan 的活性代谢产物，作为一种高选择性的磷酸二酯酶 (PDE III) 抑制剂，同时是一种强效血管扩张剂，能够打开 ATP 敏感的 K⁺ 通道，并具有钙敏感作用，可减轻心肌细胞凋亡、心脏重塑和心肌炎症。

(S)-C33 is a potent PDE9 inhibitor with IC50 of 11 nM.

CP-671,305 is a potent and selective PDE4D inhibitor.

ICI 63197 is a potent phosphodiesterase (PDE) 4 inhibitor with antidepressant effects.

3-O-Methylquercetin, a natural product isolated and purified from the herbs of Croton cascarilloides with antiviral, anti-inflammatory and bronchodilating effects, is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value. 3-O-Methylquercetin also inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

SC13 specifically inhibits FEN1 activity. It suppresses cancer cell proliferation and induces chromosome instability and cytotoxicity in cells, as well as sensitizes cancer cells to DNA damage-inducing therapeutic modalities and impedes cancer progression in a mouse model.

PF-04447943 is a potent, selective brain penetrant PDE9 inhibitor (Ki of 2.8, 4.5 and 18 nM) for human, rhesus and rat recombinant PDE9 respectively and high selectivity for PDE9 versus PDEs1-8 and 10-11.

NSP-805是一种高效、选择性的磷酸二酯酶 3 (PDE3) 抑制剂，具有强心和血管扩张作用，适用于心血管疾病的研究，特别是在治疗心力衰竭和血液循环不良方面有广泛应用。

PDE5-IN-9是一种 PDE5 抑制剂 (IC50: 11.2 μM)，与 Gln 817、Tyr 612 和 Ala 767 氨基酸残基相互作用，可用于心血管疾病的研究。

HA155是一种高效、选择性的 ATX (自噬酰基转移酶) 抑制剂，其 IC₅₀ 为 5.7 nM，适用于肿瘤和纤维化等疾病的研究，尤其是在涉及 ATX 信号通路时具有重要的治疗潜力。

Dasantafil是一种小分子磷酸二酯酶 5A (PDE5A) 抑制剂，主要用于研究泌尿生殖系统疾病，特别是勃起功能障碍的治疗。

(E/Z)-HA155是一种强效的自分泌运动因子 autotaxin (ATX) I 型抑制剂，能够抑制 ATX-LPA 信号通路，具有研究癌症、纤维化、炎症和疼痛的潜力。

PF-00489791是一种选择性磷酸二酯酶 5A (PDE5A) 抑制剂，IC₅₀ 为 1.5 nM，能够通过增强肾脏血管的松弛来降低血压并改善肾功能，特别适用于高血压和糖尿病肾病的治疗研究。