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7-(2,3-Dihydroxypropyl)theophylline

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Chemical Structure| 479-18-5 同义名 : Diprophylline;Diphylline;Neothylline;Corphyllin;NSC 40844;NSC 14305;Neothyllin;Lufyllin;Dilor;Dyphylline
CAS号 : 479-18-5
货号 : A520792
分子式 : C10H14N4O4
纯度 : 98%
分子量 : 254.24
MDL号 : MFCD00005759
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(196.66 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(78.67 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • PDE
描述 Diphylline (Diprophylline) is an A1/A2 adenosine receptor antagonist and a cyclic nucleotide phosphodiesterase inhibitor. As a xanthine derivative, Diphylline acts as a bronchodilator and vasodilator and is potentially useful for treating chronic bronchitis and emphysema[1].[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00345930 - Recruiting July 2022 United States, California ... 展开 >> University of Southern California Recruiting Los Angeles, California, United States, 90033 Contact: Susan Milstein, RN, BSN    323-224-5441    smilstei@usc.edu    Contact: None Available          Principal Investigator: Andrew Stolz, MD          United States, Indiana Indiana University Recruiting Indianapolis, Indiana, United States, 46202-5111 Contact: Audrey Corne, RN ,EdD    317-278-3062    acorne@iu.edu    Principal Investigator: Naga P Chalasani, MD          United States, Michigan University of Michigan Recruiting Ann Arbor, Michigan, United States, 48109-0362 Contact: Ben Johnson    734-936-4886    kendalld@med.umich.edu    Principal Investigator: Robert J Fontana, MD          United States, New York Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10029 Contact: Stephanie Pagan       stephanie.pagan@mssm.edu    Contact: Jospeph odin, MD    212-241-8035    joseph.odin@mountsinai.org    United States, North Carolina Univeristy of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599-7600 Contact: Tracy Russell    919-843-2376    trussell@med.unc.edu    Contact: None Available          Principal Investigator: Paul B Watkins, MD          United States, Pennsylvania Albert Einstein Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Manisha Verma, MD MPH    215-456-2480    VegaMari@einstein.edu    Principal Investigator: Victor J Navarro, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL
参考文献

[1]Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.

[2]Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2