Milrinone is a phosphodiesterase 3 (PDE3) inhibitor with IC50 of 56 nM, it increases intracellular cyclic adenosine monophosphate resulting in improved ventricular function and vasodilation.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Cyclic nucleotide phosphodiesterases (PDEs) from the human heart were separated into three isoforms, FI, FII and FIII. Milrinone has been proved to be a potent and selective inhibitor of human cardiac FIII PDE, a "low Km" enzyme for cyclic AMP (cAMP-PDE). The IC50 value for the inhibition of FIII PDE was 0.42 μM, while those of FI and FII PDEs, "high Km" enzymes, were 38 and 19 μM, respectively[3]. The concentration of milrinone that produced 50% relaxation of tracheal spirals constricted by carbachol was 3.6 × 10-5 M; The IC50 for milrinone for lung parenchymal strips contracted by histamine was 3.2 × 10-5 M; Milrinone relaxed pulmonary artery rings constricted by norepinephrine with an IC50 of 3.8 × 10-6 M[4]. Milrinone caused a concentration-dependent increase in the cAMP level in rabbit and human platelets with similar potency. Furthermore, milrinone inhibited human platelet aggregation with an IC50 of 2 μM. It was a very potent cardiotonic agent, which concentration-dependently increased left ventricular developed pressure (LVDP) and contractility as well as cAMP in rabbit coronary smooth muscle cells[5]. In rabbit heart, partial inhibition of PDE4 by milrinone contributed to greater increases in cardiomyocyte cAMP and calcium levels[6]. In mongrel dogs underwent pulmonary artery catheterization, Milrinone led to significant increases in right ventricular function as well as significant improvements in pulmonary vascular resistance, pulmonary blood flow, and left ventricular filling[7].
Canada, Alberta
... 展开 >>
Foothills Hospital
Calgary, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Canada, British Columbia
Royal Columbian Hospital
Vancouver, British Columbia, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Canada, Manitoba
St. Boniface Hospital
Winnipeg, Manitoba, Canada
Canada, Nova Scotia
Queen Elizabeth II Hospital
Halifax, Nova Scotia, Canada
Canada, Ontario
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
The Ottawa Hospital
Ottawa, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Mount Sinai Hospital
Toronto, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Toronto Western Hospital
Toronto, Ontario, Canada
Canada, Quebec
CHUM
Montreal, Quebec, Canada
Université de Sherbrooke
Sherbrooke, Quebec, Canada
Canada
Centre hospitalier affilié universitaire de Québec
Quebec, Canada
CSSS de Trois-Rivières
Quebec, Canada 收起 <<
Canada, Alberta
... 展开 >>
Foothills Hospital
Calgary, Alberta, Canada
University of Alberta Hospital
Edmonton, Alberta, Canada
Canada, British Columbia
Royal Columbian Hospital
Vancouver, British Columbia, Canada
St. Paul's Hospital
Vancouver, British Columbia, Canada
Canada, Manitoba
St. Boniface Hospital
Winnipeg, Manitoba, Canada
Canada, Nova Scotia
Queen Elizabeth II Hospital
Halifax, Nova Scotia, Canada
Canada, Ontario
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences Centre
London, Ontario, Canada
The Ottawa Hospital
Ottawa, Ontario, Canada
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5
Mount Sinai Hospital
Toronto, Ontario, Canada
St. Michael's Hospital
Toronto, Ontario, Canada
Toronto Western Hospital
Toronto, Ontario, Canada
Canada, Quebec
CHUM
Montreal, Quebec, Canada
Université de Sherbrooke
Sherbrooke, Quebec, Canada
Canada
Centre hospitalier affilié universitaire de Québec
Quebec, Canada
CSSS de Trois-Rivières
Quebec, Canada 收起 <<
United States, Utah
... 展开 >>
University of Utah
Recruiting
Salt Lake City, Utah, United States, 84112
Contact: Ami Stuart, PhD 801-793-4800 ami.stuart@hsc.utah.edu 收起 <<
Saudi Arabia
... 展开 >> King Faisal Specialist Hospital and Research Centre
Recruiting
Jeddah, Western, Saudi Arabia, 40047
Contact: Bayan Alshaikh, MBBS 00966502088088 b_al-shaikh@hotmail.com 收起 <<
Brazil
... 展开 >> Incor - Heart Institute - University of Sao Paulo
Recruiting
Sao Paulo, Brazil, 05403000
Contact: Filomena RG Galas +551126615232 filomenagalas@hotmail.com 收起 <<
United States, Connecticut
... 展开 >>
Yale School of Medicine
Recruiting
New Haven, Connecticut, United States, 06520
Contact: Nils Petersen, MD nils.petersen@yale.edu
Principal Investigator: Nils Petersen, MD
United States, Illinois
University of Illinois College of Medicine at Chicago
Recruiting
Chicago, Illinois, United States, 60612
Contact: Ali Alaraj, MD 312-996-4842 alaraj@uic.edu
Principal Investigator: Ali Alaraj, MD
United States, Michigan
University of Michigan
Not yet recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Aditya Pandey, MD 734-615-4486 adityap@med.umich.edu
United States, New York
Northwell Health
Not yet recruiting
Manhasset, New York, United States, 11030
Contact: David Ledoux, MD 516-562-3590
Lenox Hill
Not yet recruiting
New York, New York, United States, 10065
Contact: David Ledoux, MD
United States, North Carolina
Wake Forest University Health Sciences
Recruiting
Winston-Salem, North Carolina, United States, 27157
Contact: Stacey Wolfe, MD 336-716-3842 sqwolfe@wakehealth.edu
Contact: Wendy Jenkins 336.716.3842 mailto:wejenkin@wakehealth.edu
United States, Pennsylvania
Geisinger Clinic
Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Clemens Schirmer, MD
Contact: Tejal Raichura 570.214.6084 taraichura@geisinger.edu
Thomas Jefferson University
Not yet recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Pascal M Jabbour, MD 215-955-7000 Pascal.Jabbour@jefferson.edu
Principal Investigator: Pascal M Jabbour, MD
Temple University
Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Kadir Erkmen, MD 617-697-4722 Kadir.Erkmen@tuhs.temple.edu
Contact: Kathleen Hatala Kathleen.Hatala@tuhs.temple.edu
United States, Texas
University of Texas Medical School at Houston
Recruiting
Houston, Texas, United States, 77030
Contact: Sunil Sheth, MD Sunil.A.Sheth@uth.tmc.edu
Contact: Aditya A Sanzgiri, MBBS MPH 713-704-7263 Aditya.A.Sanzgiri@uth.tmc.edu
Principal Investigator: Sunil Sheth, MD 收起 <<
Spain
... 展开 >> Hospital Donosti
Donostia, San Sebastian, Spain
Hospital Clínico Universitario de Santiago de Compostela
A Coruña, Spain
Hospital Juan Canalejo
A Coruña, Spain
Hospital San Joan de Deu
Barcelona, Spain
Hospital Universitario Reina Sofía
Córdoba, Spain
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Hospital General Universitario Gregorio Marañón
Madrid, Spain
Hospital Infantil La Paz
Madrid, Spain
Hospital Universitario Doce de Octubre
Madrid, Spain
Hospital Universitario Carlos Haya
Malaga, Spain
Hospital Virgen de la Arrixaca
Murcia, Spain
Hospital Clínico Universitario Son Dureta
Palma de Mallorca, Spain
Complejo Hospitalario Universitario de Salamanca
Salamanca, Spain
Hospital Virgen de la Salud
Toledo, Spain
Hospital Clínico de Valencia
Valencia, Spain
Hospital La Fe
Valencia, Spain
Hospital Clínico Universitario de Valladolid
Valladolid, Spain
Hospital de Cruces
Vizcaya, Spain
Hospital Miguel Servet
Zaragoza, Spain 收起 <<
United States, Missouri
... 展开 >>
Mercy Hospital
St. Louis, Missouri, United States
Canada, Alberta
University of Alberta Hospital
Edmonton, Alberta, Canada
Canada, Nova Scotia
Queens Elizabeth II Hospital
Halifax, Nova Scotia, Canada
Canada, Ontario
Kingston General Hospital
Kingston, Ontario, Canada, K7L 2V7
The Ottawa Hospital
Ottawa, Ontario, Canada
Mt Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
Sunnybrooke HSC
Toronto, Ontario, Canada
Toronto General Hospital
Toronto, Ontario, Canada
Canada, Quebec
Hopital L'Enfant-Jesus
Quebec City, Quebec, Canada
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada, J1H 5N4 收起 <<
United States, New Jersey
... 展开 >>
Newark Beth Isreal Medical Center
Newark, New Jersey, United States, 07112
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Ohio
University of Cincinnati
Cincinnati, Ohio, United States, 45219
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
United States, Texas
Baylor University Medical Center
Dallas, Texas, United States, 75226
University of Texas/St. Paul Medical Center
Dallas, Texas, United States, 75390
Texas Heart Institute
Houston, Texas, United States, 20345
Germany
Herz-und Diabeteszentrum Nordrhein-Westfalen
Gergstrab, Bad Oeynhausen, Germany, 32545
Deutsches Herfzzentrum Berlin
Augustenburger Platz, Berlin, Germany, 13353
United Kingdom
Harefield Hospital
Harefield, Middlesex, United Kingdom, UB96JH 收起 <<
United States, Illinois
... 展开 >>
Northwestern University, Bluhm Cardiovascular Institute
Recruiting
Chicago, Illinois, United States, 60611
Contact: Catherine Crooke, MArch, CCRC 312-695-4189 ccrooke@nm.org
Principal Investigator: Jonathan Rich, MD
United States, New York
Columbia University Medical Center/Vivian and Seymour Milstein Family Heart Center
Recruiting
New York, New York, United States, 10032
Contact: Danielle L. Brunjes, PhD dlt2127@columbia.edu
Principal Investigator: Maryjane A Farr, MD
United States, Wisconsin
Aurora St. Luke's Medical Center, Tendick Center for Advanced Heart Failure Therapies
Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Marilyn Miller, RN, CCRC 414-385-2432 marilyn.l.miller@aurora.org
Principal Investigator: Vinay Thohan, MD 收起 <<
Terminated(DSMC acknowledged n... 展开 >>o safety concerns with the trial, recommending that the trial be terminated due to slow enrollment) 收起 <<
-
United States, California
... 展开 >>
Stanford, California, United States
United States, Florida
Tampa, Florida, United States
United States, Illinois
Chicago, Illinois, United States
Maywood, Illinois, United States
United States, Maryland
Baltimore, Maryland, United States
United States, Massachusetts
Boston, Massachusetts, United States
United States, Missouri
Saint Louis, Missouri, United States
United States, New York
New York, New York, United States
United States, Ohio
Cleveland, Ohio, United States
Columbus, Ohio, United States
United States, Pennsylvania
Philadelphia, Pennsylvania, United States
United States, South Carolina
Charleston, South Carolina, United States
United States, Texas
Houston, Texas, United States
United States, Washington
Seattle, Washington, United States 收起 <<
Finland
... 展开 >> Children´s Hospital, Helsinki University Central Hospital
Helsinki, Finland, FIN-00029 HYKS
Sweden
Queen Silvia Children´s Hospital
Göteborg, Västra Götaland, Sweden, 416 85 收起 <<
United States, Michigan
... 展开 >>
Children's Hospital of Michigan/Hutzel Women's Hospital
Detroit, Michigan, United States, 48201-2196
United States, Pennsylvania
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104 收起 <<
Congenital Diaphragmatic Herni... 展开 >>a
Persistent Pulmonary Hypertension of the Newborn
Hypoxemic Respiratory Failure
Pulmonary Hypoplasia 收起 <<
Phase 2
Recruiting
February 2021
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Recruiting
Birmingham, Alabama, United States, 35233
Contact: Waldemar A Carlo, MD
United States, California
Stanford University
Not yet recruiting
Palo Alto, California, United States, 94304
Contact: Krisa P Van Meurs, MD
United States, Georgia
Emory University
Recruiting
Atlanta, Georgia, United States, 30303
Contact: David P Carlton, MD
United States, Iowa
University of Iowa
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Edward F Bell, MD
United States, New Mexico
University of New Mexico
Recruiting
Albuquerque, New Mexico, United States, 87131
Contact: Kristi L Watterberg, MD
United States, New York
University of Rochester
Recruiting
Rochester, New York, United States, 14642
Contact: Carl T D'Angio, MD
United States, North Carolina
RTI International
Not yet recruiting
Durham, North Carolina, United States, 27709
Contact: Abhik Das, PhD
Duke University
Not yet recruiting
Durham, North Carolina, United States, 27710
Contact: Michael Cotten, MD
United States, Ohio
Cincinnati Children's Medical Center
Not yet recruiting
Cincinnati, Ohio, United States, 45267
Contact: Brenda Poindexter, MD
Case Western Reserve University, Rainbow Babies and Children's Hospital
Recruiting
Cleveland, Ohio, United States, 44106
Contact: Michele C Walsh, MD MS
Research Institute at Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Pablo Sanchez
United States, Pennsylvania
University of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Barbara Schmidt, MD
United States, Rhode Island
Brown University, Women & Infants Hospital of Rhode Island
Not yet recruiting
Providence, Rhode Island, United States, 02905
Contact: Abbot R Laptook, MD
United States, Texas
University of Texas Southwestern Medical Center at Dallas
Not yet recruiting
Dallas, Texas, United States, 75235
Contact: Myra Wyckoff, MD
University of Texas Health Science Center at Houston
Not yet recruiting
Houston, Texas, United States, 77030
Contact: Kathleen A Kennedy, MD MPH
United States, Utah
University of Utah
Recruiting
Salt Lake City, Utah, United States, 84108
Contact: Bradley Yoder, MD 收起 <<
United States, Tennessee
... 展开 >>
Vanderbilt University Medical Center
Recruiting
Nashville, Tennessee, United States, 37204
Contact: Zachary L Cox, PharmD 901-201-1683 zachary.l.cox@vanderbilt.edu
Principal Investigator: Nicholas Haglund, MD
Principal Investigator: Zachary L Cox, PharmD 收起 <<
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