Pre-treatment with 1 μM Sildenafil enhances the phosphorylation of ERK1/ERK2, increases the percentage of cells in S phase, and promotes cell proliferation compared to serotonin stimulation alone (P<0.05). Additionally, pretreatment with 1 μM Sildenafil citrate followed by serotonin stimulation significantly increases the OD value to 0.33, which is significantly different from serotonin stimulation alone (P<0.05). Moreover, 1 μM Sildenafil markedly enhances the upregulation of ERK1/ERK2 phosphorylation induced by serotonin[2].
体内研究
In the dog model of erection, Sildenafil citrate significantly increases ICP and ICP/BP but has no significant effect on BP compared to vehicle[1].
Sildenafil treatment significantly reduces the number of TL+-cells at 10 mg/kg but not at 0.5 mg/kg. Additionally, 8 days after pMCAo, Sildenafil treatment (0.5 and/or 10 mg/kg dose) significantly reduces the number of microglia/macrophages stained by Iba-1[3].
Sildenafil citrate has been reported to decrease flap necrosis in preclinical animal models by increasing the secretion of growth factors (FGF and VEGF). Histologically, it is shown to be effective in rat cavernous nerve architecture[4].
体外研究
Pre-treatment with 1 μM Sildenafil enhances the phosphorylation of ERK1/ERK2, increases the percentage of cells in S phase, and promotes cell proliferation compared to serotonin stimulation alone (P<0.05). Additionally, pretreatment with 1 μM Sildenafil citrate followed by serotonin stimulation significantly increases the OD value to 0.33, which is significantly different from serotonin stimulation alone (P<0.05). Moreover, 1 μM Sildenafil markedly enhances the upregulation of ERK1/ERK2 phosphorylation induced by serotonin[2].
Sildenafil 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
CHO cells
Function assay
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=3.31131 μM
18448342
COS7 cells
Function assay
Inhibition of human recombinant PDE5A1 expressed in COS7 cells, IC50=0.075 μM
18778098
HEK293T cells
Function assay
2 h
Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs by liquid scintillation counter, Ki=0.19953 μM
22563707
HEK293T cells
Function assay
45 mins
Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis, IC50=4.5 μM
Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique, IC50=3.31131 μM
18448342
COS7 cells
Function assay
Inhibition of human recombinant PDE5A1 expressed in COS7 cells, IC50=0.075 μM
18778098
HEK293T cells
Function assay
2 h
Displacement of [3H]ZM241385 from human AA2AR expressed in HEK293T cells after 2 hrs by liquid scintillation counter, Ki=0.19953 μM
22563707
HEK293T cells
Function assay
45 mins
Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate assessed as kynurenine formation after 45 mins by spectrophotometric analysis, IC50=4.5 μM
23122865
human erythrocytes
Function assay
60 mins
Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scintillation counting, Ki=1.2 μM
22380603
sf9 cells
Function assay
Inhibition of human PDE5A1 expressed in baculovirus in sf9 cells by PDE Glo phosphodiesterase assay, IC50=5.6 nM
United States, California
... 展开 >>
Stanford University
Recruiting
Stanford, California, United States, 94305
Contact: Elidia C Tafoya, MPH 650-724-1982 econtrer@stanford.edu
Contact: Joyce Teng, MD, PhD (650) 723-6493 jteng3@stanford.edu
Principal Investigator: Joyce Teng, MD, PhD
Sub-Investigator: Anthony Mancini, MD
Sub-Investigator: Anna Bruckner, MD
United States, Colorado
University of Colorado, Denver
Recruiting
Aurora, Colorado, United States, 80045-2571
Contact: Anna Bruckner, MD 720-777-0955 ANNA.BRUCKNER@UCDENVER.EDU
Principal Investigator: Anna Bruckner, MD
United States, Illinois
Ann & Robert H. Lurie Children's Hospital of Chicago
Recruiting
Chicago, Illinois, United States, 60611
Contact: Thy Huynh, MD 312-227-6486 MAsztalos@luriechildrens.org
Contact: Thy Huynh, MD 312.227.6486 thy.huynh@northwestern.edu
Principal Investigator: Anthony Mancini, MD 收起 <<
United States, New Mexico
... 展开 >>
Clinical Translational Science Center
Recruiting
Albuquerque, New Mexico, United States, 87131
Principal Investigator: Joe R Anderson, PharmD 收起 <<
China
... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Beijing, China, 100853
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Changsha, China, 410008
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Hangzhou, China, 310003
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Nanjing, China, 210008
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Shanghai, China, 200080
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Shenzhen, China, 518036
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Tianjin, China, 300211
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Wu Han, China, 430030
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Xi'An, China, 710004 收起 <<
Withdrawn(The Investigator-Coo... 展开 >>rdinator has moved to Rennes University Hospital. It will be done under the sponsor of Rennes University Hospital NCT03686306) 收起 <<
United States, Alabama
... 展开 >>
University of Alabama - Birmingham
Birmingham, Alabama, United States, 35294
United States, California
University of California - Los Angeles
Los Angeles, California, United States, 90095
University of California - San Francisco
San Francisco, California, United States, 94110
United States, Colorado
National Jewish Medical and Research Center
Denver, Colorado, United States, 80206
United States, Georgia
Emory University
Atlanta, Georgia, United States, 30322
United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
United States, Louisiana
Tulane University
New Orleans, Louisiana, United States, 70118
United States, Michigan
University of Michigan
Ann Arbor, Michigan, United States, 48109
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, New York
Weill Medical College of Cornell University
New York, New York, United States, 10021
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Tennessee
Vanderbilt University
Nashville, Tennessee, United States, 37232
United States, Washington
University of Washington
Seattle, Washington, United States, 98165 收起 <<
United States, Pennsylvania
... 展开 >>
Penn State Hershey Medical Center
Recruiting
Hershey, Pennsylvania, United States, 17033
Contact: Chowdhury dchowdhury@hmc.psu.edu
Principal Investigator: Devyani Chowdhury, MD
Sub-Investigator: Stephen E Cyran, MD
Sub-Investigator: Matthew S. Dean, MS 收起 <<
Israel
... 展开 >> Lady Davis Carmel Medical CEnter
Haifa, Israel, 34362
Rabin Medical Center
Petah Tikva, Israel, 49100
Italy
San Donato Hospital
Milano, Italy, 20097
Norway
Stavanger University Hospital
Stavanger, Rogaland, Norway, 4011
United Kingdom
Castle Hill Hospital
Hull, United Kingdom, HU16 5JQ
Northern General Hospital
Sheffield, United Kingdom, S5 7AU 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University Bundang Hospital
Recruiting
Seongnam, Gyeonggido, Korea, Republic of, 463-707
Contact: Sang Eun Lee, Professor 82-31-787-7349 urojsj@empal.com
Contact: Seong Jin Jeong, Professor 82-31-787-7349 urojsj@empal.com
Principal Investigator: Sang Eun Lee, Professor 收起 <<
United States, Arkansas
... 展开 >>
University of Arkansas for Medical Sciences
Recruiting
Little Rock, Arkansas, United States, 72205
Principal Investigator: Sherry Courtney, MD
United States, Indiana
Riley Hospital for Children at IU Health
Recruiting
Indianapolis, Indiana, United States, 46202
Principal Investigator: Gregory Sokol, MD
United States, Kansas
Wesley Medical Center
Recruiting
Wichita, Kansas, United States, 67214
Principal Investigator: Barry Bloom, MD
United States, Louisiana
Ochsner Baptist Medical Center
Recruiting
New Orleans, Louisiana, United States, 70115
Principal Investigator: Amanda England, MD
United States, Nevada
Children's Hospital of Nevada at UMC
Recruiting
Las Vegas, Nevada, United States, 89106
Contact: Ronald Roemer 702-207-8345 Ronald.Roemer@umcsn.com
Principal Investigator: Alaa Eldemerdash, MD
United States, New York
Kings County Hospital Center
Recruiting
Brooklyn, New York, United States, 11203
Principal Investigator: Gratias Mundakel, MD
Cohen Children's Medical Center of NY
Recruiting
New Hyde Park, New York, United States, 11040
Principal Investigator: Mohamed N Ahmed, MD
Golisano Children's Hospital - University of Rochester Medical Center
Recruiting
Rochester, New York, United States, 14642
Principal Investigator: Gloria Pryhuber, MD
United States, North Carolina
WakeMed Health and Hospitals
Recruiting
Raleigh, North Carolina, United States, 27610
Principal Investigator: Stephen Kicklighter, MD
United States, Ohio
Cincinnati Childrens Hospital Medical Center
Recruiting
Cincinnati, Ohio, United States, 45229
Principal Investigator: Brenda Poindexter, MD
United States, Oklahoma
University of Oklahoma
Recruiting
Oklahoma City, Oklahoma, United States, 73104
Principal Investigator: Kimberly Ernst, MD 收起 <<
United States, Minnesota
... 展开 >>
Mayo Clinic in Rochester
Recruiting
Rochester, Minnesota, United States, 55905
Contact: Alexander Egbe, MD MOH
Principal Investigator: Alexander C Egbe 收起 <<
Canada, Alberta
... 展开 >>
University of Calgary
Recruiting
Calgary, Alberta, Canada, T2N 4Z6
University of Calgary
Recruiting
Calgary, Alberta, Canada
Contact: Jonathan G Howlett, MD 收起 <<
United States, Pennsylvania
... 展开 >>
Penn Presbyterian Medical Center
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact 800-789-7366
Principal Investigator: Ramon Diaz-Arrastia, MD, PhD
Sub-Investigator: Danielle Sandsmark, MD, PhD 收起 <<
United States, Mississippi
... 展开 >>
University of Mississippi Medical Center
Recruiting
Jackson, Mississippi, United States, 39216
Contact: Chad W Washington, MS, MD, MPHS 601-984-5700 cwashington4@umc.edu 收起 <<
Persistent Pulmonary Hypertens... 展开 >>ion of the Newborn 收起 <<
Phase 1
Completed
-
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35249-7335
United States, Indiana
Riley Hospital
Indianapolis, Indiana, United States, 46202
United States, Kentucky
Kosair Pediatric Research Unit
Louisville, Kentucky, United States, 40202
United States, New York
Albany Medical Center
Albany, New York, United States, 12208
Kings County Hospital Center/SUNY Downstate Medical Center
Brooklyn, New York, United States, 11203
United States, North Carolina
University of North Carolina
Chapel Hill, North Carolina, United States, 27599
Duke University
Durham, North Carolina, United States, 27705
United States, Ohio
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425 收起 <<
United States, North Carolina
... 展开 >>
Duke University Medical Center
Not yet recruiting
Durham, North Carolina, United States, 27710
Contact: Richard E Moon, MD 919-684-8762 richard.moon@duke.edu
Contact: Michael Natoli, MS 919-684-6726 michael.natoli@duke.edu 收起 <<
United States, Illinois
... 展开 >>
Department of Dermatology, Northwestern University Feinberg School of Medicine
Recruiting
Chicago, Illinois, United States, 60611
Contact: Jennifer N Choi, MD 312-695-8106 jennifer.choi@northwestern.edu
Contact: Linda Serrano, MD 312-503-5903 linda.serrano@northwestern.edu
Principal Investigator: Jennifer N Choi, MD
Sub-Investigator: Linda Serrano, MD
Northwestern Memorial Hospital
Recruiting
Chicago, Illinois, United States, 60611
Contact: Jennifer N Choi, MD 312-695-8106 jennifer.choi@northwestern.edu
Contact: Linda Serrano, MD 312-503-5903 linda.serrano@northwestern.edu
Principal Investigator: Jennifer N Choi, MD
Sub-Investigator: Linda Serrano, MD 收起 <<
United States, Texas
... 展开 >>
University of Texas Southwestern Medical Center
Recruiting
Dallas, Texas, United States, 75390
Contact: Joshua W. Gatson, Ph.D. 214-648-0499 ext 80499 joshua.gatson@utsouthwestern.edu 收起 <<
Suspended(STRIDER-Canada trial... 展开 >> suspended recruitment until further information can be obtained following release of the Dutch DSMB recommendation for their Study) 收起 <<
December 2019
Canada, Alberta
... 展开 >>
Royal Alexandra Hospital
Edmonton, Alberta, Canada, T5H 3V9
Canada, British Columbia
BC Women's Hospital/University of British Columbia
Vancouver, British Columbia, Canada, V7H3N1
Canada, Ontario
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Canada, Quebec
CHU Sainte-Justine
Montréal, Quebec, Canada, H3T 1C5
CHU de Quebec - Universite Laval
Quebec City, Quebec, Canada, G2N 0B2 收起 <<
Brazil
... 展开 >> Pfizer Investigational Site
Belo Horizonte, MG, Brazil, 30130-008
Pfizer Investigational Site
Rio de Janeiro, RJ, Brazil, 20551-030
Pfizer Investigational Site
Rio Claro, SP, Brazil, 13500-020
Pfizer Investigational Site
Sao Paulo, SP, Brazil, 04044-060
Pfizer Investigational Site
Sao Paulo, SP, Brazil, 04262-000
Germany
Pfizer Investigational Site
Frankfurt, Germany, 65929
Pfizer Investigational Site
Marburg, Germany, 35039
Pfizer Investigational Site
Muenchen, Germany, 81369
Pfizer Investigational Site
Muenchen, Germany, 81925
Pfizer Investigational Site
Rosenheim, Germany, D 83022
Pfizer Investigational Site
Starnberg, Germany, 82319
Italy
Pfizer Investigational Site
Catania, Italy, 95124
Pfizer Investigational Site
Firenze, Italy, 50139
Pfizer Investigational Site
Roma, Italy, 00161
Poland
Pfizer Investigational Site
Lodz, Poland, 90-625
Pfizer Investigational Site
Lodz, Poland, 93-171
Pfizer Investigational Site
Lublin, Poland, 20-008
Pfizer Investigational Site
Szczecin, Poland, 71-240
Pfizer Investigational Site
Warszawa, Poland, 00-911
Turkey
Pfizer Investigational Site
Bursa, Turkey, 16070
Pfizer Investigational Site
Diyarbakir, Turkey, 21280
Pfizer Investigational Site
Istanbul, Turkey, 34900
Pfizer Investigational Site
Izmir, Turkey, 35100 收起 <<
United States, Iowa
... 展开 >>
University of Iowa
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Debra O'Connell-Moore, BS 319-356-1785 debra-oconnell-moore@uiowa.edu
Contact: Ann Thompson 319-353-6213 ann-thompson@uiowa.edu
Principal Investigator: Eric A Hoffman, Ph.D. 收起 <<
Primary and Secondary Pulmonar... 展开 >>y Hypertension 收起 <<
Not Applicable
Withdrawn(We can't obtained th... 展开 >>e test drug (Vadenafil) from Bayer. They decided not to carry out this trail in Taiwan. Therefore this trail has never been started.) 收起 <<
Belgium
... 展开 >> Dept. of Pneumology, University
Recruiting
Leuven, Belgium
Contact: Marion Delcroix, MD, PhD
Principal Investigator: Marion Delcroix, MD, PhD
Germany
DRK-Klinikum Köpenick
Recruiting
Berlin, Germany
Contact: Christian Opitz, MD, PhD
Principal Investigator: Christian Opitz, MD, PhD
Lung Centre, University of Giessen
Recruiting
Giessen, Germany
Contact: Ardeschir Ghofrani, MD, PhD
Principal Investigator: Ardeschir Ghofrani, MD
Sub-Investigator: Melanie Thamm, MD
Department of Pulmology; Hannover Medical School
Recruiting
Hannover, Germany
Contact: Marius M Hoeper
Principal Investigator: Marius M Hoeper, MD, PhD
Sub-Investigator: Karen Olsson, MD
German Heart Centre
Recruiting
Munich, Germany
Contact: Harald Kaemmerer, MD,. PhD
Principal Investigator: Harald Kaemmerer, MD, PhD
Ireland
Mater Misericordiae
Recruiting
Dublin, Ireland
Contact: Sean Gaine, MD, PhD
Principal Investigator: Sean Gaine, MD, PhD
Italy
Department of Cardiovascular and Respiratory Sciences, University La Sapienza
Recruiting
Rome, Italy
Contact: Dario Vizza, MD, PhD
Principal Investigator: Dario Vizza, MD, PhD
Switzerland
Dept. for Rheumatology, University Hospital
Recruiting
Zurich, Switzerland
Contact: Oliver Distler, MD, PhD
Principal Investigator: Oliver Distler, MD, PhD 收起 <<
United States, California
... 展开 >>
Children's Hospital Oakland
Oakland, California, United States, 94609
United States, Massachusetts
Children's Hospital
Boston, Massachusetts, United States, 02115
United States, New York
Weill Medical College of Cornell University
New York, New York, United States, 10021
United States, Pennsylvania
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Canada, Ontario
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
Israel
... 展开 >> Pulmonary Institute, Rabin Medical Center
Not yet recruiting
Petach Tikva, Israel, 49100
Sub-Investigator: Benjamin D Fox, BM BCh MRCP 收起 <<
Russian Federation
... 展开 >>
First Pavlov State Medical University of St. Petersburg
Recruiting
Saint-Petersburg, Russian Federation, 197089
Contact: Ivan S. Moiseev, MD, PhD +79217961951 moisiv@mail.ru
Contact: Elena V Morozova, MD, PhD +79119278229 dr_morozova@mail.ru
Principal Investigator: Boris V Afanasyev, MD, Prof
Sub-Investigator: Elena V Morozova, MD, PhD
Sub-Investigator: Yulia V Rudnizkaya, MD, PhD
Sub-Investigator: Ivan S Moiseev, MD, PhD
Sub-Investigator: Nikolai Yu Tcvetkov, MD 收起 <<
France
... 展开 >> Université Paris Descartes, Hôpital Cochin, Service de Rhumatologie A & INSERM 1016
Recruiting
Paris, France, 75014
Principal Investigator: Yannick Allanore, Prof.
Germany
Justus-Liebig-University Gießen, Kerckhoff Clinic, Departement of Rheumatology and Clinical Immunology
Recruiting
Bad Nauheim, Germany, 61231
Principal Investigator: Ulf Müller-Ladner, Prof.
Sub-Investigator: Ingo H. T, Dr.
Sub-Investigator: Marc Frerix, Dr.
Charité Universitätsmedizin Berlin, Charité Centrum 12 für Innere Medizin und Dermatologie, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
Recruiting
Berlin, Germany, 10117
Principal Investigator: Gabriela Riemekasten, Prof.
Centre for Pediatric Rheumatology, Klinikum Eilbek
Recruiting
Hamburg, Germany, 22081
Principal Investigator: Ivan Foeldvari, Dr.
Hungary
Pecsi Tudomanyegyetem - University of Pecs
Recruiting
Pecs, Hungary, H-7622
Principal Investigator: Laszlo Czirjak, Prof.
Italy
University of Florence, Denothe Centre, Division of Rheumatology AOUC, Department of Biomedicine
Recruiting
Firenze, Italy, 50139
Principal Investigator: Marco Matucci-Cerinic, Prof.
Policlinico, Via Pansini
Recruiting
Napoli-Italia, Italy, 5-80131
Principal Investigator: Gabriele Valentini, Prof.
Switzerland
Felix-Platter Spital, University of Basel
Recruiting
Basel, Switzerland, CH 4012
Principal Investigator: Ulrich Walker, Prof.
University of Zurich, Department of Rheumatology
Recruiting
Zurich, Switzerland, 8006
Principal Investigator: Oliver Distler, Prof.
United Kingdom
The Universitiy of Leeds, Division of Rheumatic and Musculoskeletal Disease, St James's University Hospital
Recruiting
Leeds, United Kingdom, LS9 7TF
Principal Investigator: Francesco Del Galdo, Dr.
Royal Free Hospital, University College London
Recruiting
London, United Kingdom, NW3 2QG
Principal Investigator: Christopher Denton, Prof. 收起 <<
United States, California
... 展开 >>
Greider Eye Associates
Vista, California, United States, 92083
United States, Florida
Palm Beach Eye Center
Atlantis, Florida, United States, 33461
West Coast Eye Care
Fort Myers, Florida, United States, 33908
National Ophthalmic Research Institute
Fort Myers, Florida, United States, 33912
Sarasota Retina Institute
Sarasota, Florida, United States, 34239
United States, Indiana
Midwest Eye Institute
Indianapolis, Indiana, United States, 46290
United States, Michigan
Spoor and Associates
Warren, Michigan, United States, 48088
United States, North Carolina
Asheville Eye Associates
Asheville, North Carolina, United States, 28803
United States, Ohio
Office of Dr. Avrom Epstein, MD
Columbus, Ohio, United States, 43215-7312
United States, Oklahoma
Tulsa Clinical Research, LLC
Tulsa, Oklahoma, United States, 74014
United States, Texas
Retinal and Ophthalmic Consultants
Houston, Texas, United States, 77030
Australia, New South Wales
Save Sight Institute
Sydney, New South Wales, Australia, 2000
Canada, Ontario
Midwest Eye Institute
Toronto, Ontario, Canada, M5G 1X5 收起 <<
United States, Colorado
... 展开 >>
University of Colorado at Denver and Health Sciences Center
Aurora, Colorado, United States, 80045
Denmark
University of Aarhus
Aarhus, Denmark 收起 <<
United States, Indiana
... 展开 >>
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Indianapolis, Indiana, United States 收起 <<
United States, California
... 展开 >>
Catalina Research Institute
Chino, California, United States, 91710
University of California San Diego
San Diego, California, United States, 92103
United States, Colorado
Rocky Mountain Research
Wheat Ridge, Colorado, United States, 80033
United States, Georgia
Atlanta Gastroenterology Associates
Atlanta, Georgia, United States, 30312
GI Specialists of Georgia
Marietta, Georgia, United States, 30060
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
United States, Indiana
Indiana University
Indianapolis, Indiana, United States, 46202
United States, North Carolina
University of North Carolina Chapel Hill
Chapel Hill, North Carolina, United States, 27599
United States, Ohio
Sterling Research
Cincinnati, Ohio, United States, 45246
United States, Tennessee
Premier Clinical Research
Clarksville, Tennessee, United States, 37043
Gastro One
Germantown, Tennessee, United States, 38138
Quality Medical Research
Nashville, Tennessee, United States, 37211
United States, Virginia
Virginia Commonwealth University
Richmond, Virginia, United States, 23298 收起 <<
Terminated(Safety Issue The tr... 展开 >>ial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.) 收起 <<
Terminated(Safety Issue The tr... 展开 >>ial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.) 收起 <<
Australia, Western Australia
... 展开 >>
Keogh Institute for Medical Research, 'A' Block 3rd Floor, QE II Medical Centre, Nedlands
Perth, Western Australia, Australia, 6009 收起 <<
Korea, Republic of
... 展开 >>
Inje University Ilsan Paik Hospital
Recruiting
Goyang-si, Korea, Republic of
National Health Insurance Service Ilsan Hospital
Recruiting
Goyang-si, Korea, Republic of
Pusan National University Hospital
Recruiting
Pusan, Korea, Republic of
Catholic Medical Center Seoul St. Mary's Hospital
Recruiting
Seoul, Korea, Republic of
Ewha Womans University Medical Center
Recruiting
Seoul, Korea, Republic of
Korea University Guro Hospital
Recruiting
Seoul, Korea, Republic of
Samsung Medical Center
Recruiting
Seoul, Korea, Republic of
Seoul National University Hospital
Recruiting
Seoul, Korea, Republic of
Catholic university of Korea Uijeongbu St.Mary's Hospital
Not yet recruiting
Uijeongbu-si, Korea, Republic of 收起 <<
United States, Alabama
... 展开 >>
AMR
Mobile, Alabama, United States, 36608
United States, California
Catalina Research Institute
Montclair, California, United States, 91763
Northern California Research
Sacramento, California, United States, 95821
United States, Idaho
ACR
Meridian, Idaho, United States, 83642
United States, Illinois
Synexus
Chicago, Illinois, United States, 60602
United States, Louisiana
Pennington Biomedical Research Center
Baton Rouge, Louisiana, United States, 70808
Clinical Trials Management
Metairie, Louisiana, United States, 70006
United States, Missouri
Synexus
Saint Louis, Missouri, United States, 63141
United States, Nevada
AMR
Las Vegas, Nevada, United States, 89119
United States, Ohio
Rapid Medical Research
Cleveland, Ohio, United States, 44122
United States, South Carolina
Medical Research South
Charleston, South Carolina, United States, 29407
United States, Tennessee
Premier
Clarksville, Tennessee, United States, 37040
United States, Texas
Synexus
Dallas, Texas, United States, 75234
Synexus
San Antonio, Texas, United States, 78229
United States, Utah
ACR
Jordan, Utah, United States, 84088 收起 <<
United States, California
... 展开 >>
San Diego Sexual Medicine
San Diego, California, United States, 92120
United States, District of Columbia
The Center for Vulvovaginal Disorders
Washington, District of Columbia, United States, 20037
United States, Florida
Meridien Research
Brooksville, Florida, United States, 34601
Segal Institute Women's Health Clinic
North Miami, Florida, United States, 33161
Compass Research
Orlando, Florida, United States, 32806
Miami Research Associates
South Miami, Florida, United States, 33143
Meridien Research
St Petersburg, Florida, United States, 34203
Comprehensive Clinical Trials, LLC
West Palm Beach, Florida, United States, 33409
United States, Maryland
Annapolis Sexual Wellness Center
Annapolis, Maryland, United States, 21401
Maryland Prime Care Physicians
Stevensville, Maryland, United States, 21666
Center for Sexual Medicine at Sheppard Pratt
Townson, Maryland, United States, 22104
United States, New Jersey
Women's Health Research Center
Plainsboro, New Jersey, United States, 08536
United States, New York
Michael A. Werner, MD PC
Purchase, New York, United States, 10577
United States, Pennsylvania
Philadelphia Clinical Research
Philadelphia, Pennsylvania, United States, 19114 收起 <<
India
... 展开 >> All India Institute Of Medical Sciences
Recruiting
New Delhi, Delhi, India, 110029
Contact: Sajal Ajmani, MBBS 9873570408 sajalajmani@gmail.com
Principal Investigator: Surendra K Sharma, MD, Ph D 收起 <<
Prostate Cancer
... 展开 >> Erectile Dysfunction Following Radical Prostatectomy
Erectile Dysfunction Following Simple Prostatectomy
Erectile Dysfunction 收起 <<
Not Applicable
Terminated(Slow accrual)
-
United States, Ohio
... 展开 >>
University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44106 收起 <<
Brazil
... 展开 >> Instituto do Coração (InCor) HCFMUSP
Recruiting
São Paulo, Brazil, 05403-900
Contact: Antonio Augusto Lopes, M.D. 55-11-2661-5000 ext 5350 aablopes@usp.br
Contact: Roseli Polo, Assistant 55-11-2661-5000 ext 5350 roseli.polo@incor.usp.br
Sub-Investigator: Ana Maria Thomaz, M.D.
Sub-Investigator: Nair Y. Maeda, PhD
Sub-Investigator: Vera D. Aiello, M.D.
Sub-Investigator: Luiz J. Kajita, M.D.
Sub-Investigator: Filomena Regina BG Galas, M.D.
Sub-Investigator: Leína Zorzanelli, M.D.
Sub-Investigator: Arlindo A. Riso, M.D.
Sub-Investigator: Marcelo B. Jatene, M.D.
Sub-Investigator: Sérgio P. Bydlowski, M.D. 收起 <<
Norway
... 展开 >> Pfizer Investigational Site
Oslo, Norway
United Kingdom
Pfizer Investigational Site
Belfast, Northern Ireland, United Kingdom, BT9 6AD
Pfizer Investigational Site
Leeds, West Yorkshire, United Kingdom, LS2 9LH 收起 <<
Pulmonary Embolism
... 展开 >> Intermediate-high Risk
Combination of Oral Anticoagulation Therapy and Sildenafil 收起 <<
Phase 1
Recruiting
October 2020
Russian Federation
... 展开 >>
Federal State Institution Academician E.N.Meshalkin Novosibirsk State Research Institute Of Circulation Pathology Rusmedtechnology
Recruiting
Novosibirsk, Russian Federation, 630055
Contact: Artem Rabtsun +79137078354 a_rabtsun@meshalkin.ru 收起 <<
France
... 展开 >> Pfizer Investigational Site
Amphion-Les-Bains, France
Pfizer Investigational Site
Bordeaux, France
Pfizer Investigational Site
La Rochelle, France
Pfizer Investigational Site
Lille, France
Pfizer Investigational Site
Lyon Cedex 03, France
Pfizer Investigational Site
Lyon, France
Pfizer Investigational Site
PARIS Cedex 13, France
Pfizer Investigational Site
Paris, France
Pfizer Investigational Site
Saint-Emilion, France
Pfizer Investigational Site
Thionville, France
Pfizer Investigational Site
Toulouse, France 收起 <<
Israel
... 展开 >> Rambam Health Care Campus
Not yet recruiting
Haifa, Israel
Contact: Ilan Gruenwald, MD 0097248542882 i_gruenwald@rambam.health.gov.il 收起 <<
United States, Wisconsin
... 展开 >>
University of Wisconsin-Madison School of Medicine and Public Health
Not yet recruiting
Madison, Wisconsin, United States, 53792
Contact: Tina M Palas, BS 608-265-4554 tmp@medicine.wisc.edu
Contact: Mary Jo M Jackson, BSN 608-265-3556 mmj@medicine.wisc.edu 收起 <<
Erectile Dysfunction
... 展开 >> Prostate Cancer 收起 <<
Phase 3
Recruiting
March 2022
United States, Texas
... 展开 >>
Brooke Army Medical Center
Recruiting
San Antonio, Texas, United States, 78234
Contact: Ileana King-Letzkus 210-916-2000 ileana.e.king-letzkus.civ@mail.mil 收起 <<
Mexico
... 展开 >> Pfizer Investigational Site
Torreon, Coahuila, Mexico, 72000
Pfizer Investigational Site
Mexico, DF, Mexico, 07760
Pfizer Investigational Site
Guadalajara, Jalisco, Mexico, 44290
Pfizer Investigational Site
Colonia Centro, Mexico City, Mexico, 06090
Pfizer Investigational Site
DF, Mexico City, Mexico, 06760
Pfizer Investigational Site
Monterrey, Nuevo Leon, Mexico, 64000
Pfizer Investigational Site
Monterrey, Nuevo Leon, Mexico, 64460
Pfizer Investigational Site
Merida, Yucatan, Mexico, 97070
Pfizer Investigational Site
Aguascalientes, Mexico, C.P. 20230
Pfizer Investigational Site
Chihuahua, Mexico, 31238
Pfizer Investigational Site
Durango, Mexico, 34300
Pfizer Investigational Site
Metepec, Mexico, 52140
Pfizer Investigational Site
Puebla, Mexico, 72090
Pfizer Investigational Site
San Luis Potosi, Mexico, 78090
Pfizer Investigational Site
San Luis PotosÃ, Mexico, 78240
Pfizer Investigational Site
Veracruz, Mexico, C.P. 97897 收起 <<
Australia, New South Wales
... 展开 >>
Pfizer Investigational Site
Bondi Junction, New South Wales, Australia
Pfizer Investigational Site
Darlinghurst, New South Wales, Australia
Pfizer Investigational Site
St Leonards, New South Wales, Australia
Australia, Queensland
Pfizer Investigational Site
Spring Hill, Queensland, Australia
Australia, South Australia
Pfizer Investigational Site
Adelaide, South Australia, Australia
Australia, Victoria
Pfizer Investigational Site
Clayton, Victoria, Australia
Pfizer Investigational Site
Malvern, Victoria, Australia
Pfizer Investigational Site
Mentone, Victoria, Australia
Australia, Western Australia
Pfizer Investigational Site
Nedlands, Western Australia, Australia 收起 <<
Canada, British Columbia
... 展开 >>
University of British Columbia - Environmental Physiology Laboratory
Vancouver, British Columbia, Canada, V6T1z1 收起 <<
Prostate Cancer
... 展开 >> Psychosocial Effects of Cancer and Its Treatment
Radiation Toxicity
Sexual Dysfunction
Sexuality and Reproductive Issues 收起 <<
United States, Arizona
... 展开 >>
Phoenix, Arizona, United States, 85023
Tempe, Arizona, United States, 85282
United States, California
Beverly Hills, California, United States, 90212
La Mesa, California, United States, 91942-3058
Laguna Hills, California, United States, 92653
San Diego, California, United States, 92128
Torrance, California, United States, 90502-2004
Van Nuys, California, United States, 91405
United States, Connecticut
Waterbury, Connecticut, United States, 06708
United States, Florida
Aventura, Florida, United States, 33180
United States, Louisiana
New Orleans, Louisiana, United States, 70112
United States, Michigan
Ann Arbor, Michigan, United States, 48109-0330
United States, Minnesota
Minneapolis, Minnesota, United States, 55455
Rochester, Minnesota, United States, 55905
United States, New York
Great Neck, New York, United States, 11021
New York, New York, United States, 10016-4576
United States, Ohio
Cincinnati, Ohio, United States, 45212-2787
United States, Texas
San Antonio, Texas, United States, 78229 收起 <<
United States, California
... 展开 >>
San Diego Sexual Medicine
San Diego, California, United States, 92120
United States, Louisiana
Tulane Medical Center
New Orleans, Louisiana, United States, 70112
United States, New York
Manhattan Medical Research
New York, New York, United States, 10016 收起 <<
Terminated(This study was term... 展开 >>inated at the recommendation of an independent Data Monitoring Committee. The decision was not based on any safety concerns.) 收起 <<
Terminated(This study was term... 展开 >>inated at the recommendation of an independent Data Monitoring Committee. The decision was not based on any safety concerns.) 收起 <<
United States, Alabama
... 展开 >>
Pfizer Investigational Site
Huntsville, Alabama, United States
United States, California
Pfizer Investigational Site
San Diego, California, United States
United States, Colorado
Pfizer Investigational Site
Aurora, Colorado, United States
United States, Florida
Pfizer Investigational Site
Miami, Florida, United States
Pfizer Investigational Site
Ocala, Florida, United States
Pfizer Investigational Site
Tallahassee, Florida, United States
United States, Indiana
Pfizer Investigational Site
Jeffersonville, Indiana, United States
United States, Iowa
Pfizer Investigational Site
Des Moines, Iowa, United States
United States, Louisiana
Pfizer Investigational Site
Shreveport, Louisiana, United States
United States, Nevada
Pfizer Investigational Site
Las Vegas, Nevada, United States
United States, New York
Pfizer Investigational Site
Garden City, New York, United States
Pfizer Investigational Site
Kingston, New York, United States
Pfizer Investigational Site
New York, New York, United States
Pfizer Investigational Site
Poughkeepsie, New York, United States
United States, North Dakota
Pfizer Investigational Site
Fargo, North Dakota, United States
United States, Ohio
Pfizer Investigational Site
Cincinnati, Ohio, United States
United States, Texas
Pfizer Investigational Site
Houston, Texas, United States
Pfizer Investigational Site
San Antonio, Texas, United States
United States, Washington
Pfizer Investigational Site
Seattle, Washington, United States
Pfizer Investigational Site
Spokane, Washington, United States 收起 <<
Canada, Quebec
... 展开 >> Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ)
Québec, Quebec, Canada, G1V 4G5 收起 <<
Terminated(Study prematurely d... 展开 >>iscont’d 20-Apr-2006 after interim analysis suggested sample size could be reduced without losing power. No safety concerns led to decision.) 收起 <<
-
United Kingdom
... 展开 >> Pfizer Investigational Site
Pembury, Kent, United Kingdom, TN2 4QJ
Pfizer Investigational Site
Royal Tunbridge Wells, Kent, United Kingdom, TN1 1JU
Pfizer Investigational Site
Ashton under Lyne, Lancs, United Kingdom, 0L6 9RW
Pfizer Investigational Site
Bolton, United Kingdom, BL4 0JR
Pfizer Investigational Site
Dundee, United Kingdom, DD1 9SY
Pfizer Investigational Site
Fife, United Kingdom, KY2 5RA
Pfizer Investigational Site
London, United Kingdom, SE1 7EH
Pfizer Investigational Site
London, United Kingdom, SW10 9NH
Pfizer Investigational Site
Manchester, United Kingdom, M14 0JH
Pfizer Investigational Site
Manchester, United Kingdom, M6 8HD 收起 <<
United States, Alabama
... 展开 >>
Robert Bourge MD
Birmingham, Alabama, United States, 35294
United States, California
Ron Oudiz
Torrance, California, United States, 90502
United States, Florida
Charles Burger MD
Jacksonville, Florida, United States, 32224 收起 <<
Prostate Cancer
... 展开 >> Erectile Dysfunction 收起 <<
Phase 3
Completed
-
United States, New Jersey
... 展开 >>
Memorial Sloan-Kettering Cancer Center at Basking Ridge
Basking Ridge, New Jersey, United States, 07920
United States, New York
Memorial Sloan-Kettering Cancer Center at Commack
Commack, New York, United States, 11725
Memorial Sloan-Kettering Cancer Center
New York, New York, United States, 10021
Memorial Sloan-Kettering Cancer Center at Mercy Medical Center
Rockville Centre, New York, United States, 11570
Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center
Sleepy Hollow, New York, United States, 10591 收起 <<
Terminated(Safety Issue The tr... 展开 >>ial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.) 收起 <<
United States, Pennsylvania
... 展开 >>
Penn Presbyterian Medical Center
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact 800-789-7366
Principal Investigator: Ramon Diaz-Arrastia, MD, PhD
Sub-Investigator: Danielle Sandsmark, MD, PhD 收起 <<
Egypt
... 展开 >> Menoufia University
Recruiting
Shebin Elkom, Egypt
Principal Investigator: tarek sayed
Saudi Arabia
Alhayah national hospital
Recruiting
Abha, Saudi Arabia
Principal Investigator: mohamed maher 收起 <<
United States, Washington
... 展开 >>
Pfizer Investigational Site
Seattle, Washington, United States, 98105
Pfizer Investigational Site
Seattle, Washington, United States, 98195-6465
Australia, Western Australia
Pfizer Investigational Site
Nedlands, Western Australia, Australia, 6009 收起 <<
United States, Florida
... 展开 >>
Novartis Investigative Site
Tampa, Florida, United States, 33606
Novartis Investigative Site
Weston, Florida, United States, 33331
United States, New York
Novartis Investigative Site
Mineola, New York, United States, 11501
Australia, New South Wales
Novartis Investigative Site
Darlinghurst, New South Wales, Australia, 2010
Belgium
Novartis Investigative Site
Bruxelles, Belgium, 1070
Novartis Investigative Site
Leuven, Belgium, 3000
Germany
Novartis Investigative Site
Berlin, Germany, 12683
Novartis Investigative Site
Hannover, Germany, 30625
Italy
Novartis Investigative Site
Roma, RM, Italy, 00161
Lithuania
Novartis Investigative Site
Vilnius, Lithuania, LT-08661
United Kingdom
Novartis Investigative Site
London, United Kingdom, NW3 2PR 收起 <<
United States, Tennessee
... 展开 >>
Vanderbilt University Medical Center
Recruiting
Nashville, Tennessee, United States, 37232
Contact: Keisha Card, RN keisha.card@vanderbilt.edu
Principal Investigator: Cyndya A Shibao, MD
Principal Investigator: Naji N Abumrad, MD 收起 <<
Australia, New South Wales
... 展开 >>
Pfizer Investigational Site
Bondi Junction, New South Wales, Australia
Australia, Queensland
Pfizer Investigational Site
Brisbane, Queensland, Australia
Australia, Victoria
Pfizer Investigational Site
East Melbourne, Victoria, Australia
Pfizer Investigational Site
Melbourne, Victoria, Australia 收起 <<
Terminated(Safety Issue The tr... 展开 >>ial was prematurely terminated on Dec 9, 2010, due to safety concerns, specifically new emerging evidence of hepatic injury.) 收起 <<
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