货号:A139945
同义名:
BL4162A;Anagrelide (hydrochloride)
Anagrelide HCl is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation.
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免费溶解
产品名称 | PDE ↓ ↑ | PDE1 ↓ ↑ | PDE10A ↓ ↑ | PDE2 ↓ ↑ | PDE3 ↓ ↑ | PDE4 ↓ ↑ | PDE5 ↓ ↑ | PDE6 ↓ ↑ | 其他靶点 | 纯度 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Doxofylline | ✔ | 99+% | |||||||||||||||||
Deltarasin |
+++
PDEδ , Kd: 38 nM |
99+% | |||||||||||||||||
7-(2,3-Dihydroxypropyl)theophylline | ✔ | 99%+ | |||||||||||||||||
Aminophylline |
+
PDE, IC50: 0.12 mM |
99%+ | |||||||||||||||||
Anagrelide HCl | ✔ | 99%+ | |||||||||||||||||
Irsogladine | ✔ | mAChR,AChR | 99%+ | ||||||||||||||||
PF-8380 |
+++
Autotaxin, IC50: 2.8 nM |
99%+ | |||||||||||||||||
Dipyridamole | ✔ | 99%+ | |||||||||||||||||
Balipodect |
++++
PDE10A, IC50: 0.3 nM |
99%+ | |||||||||||||||||
PF-2545920 |
++++
PDE10A, IC50: 0.37 nM |
97% | |||||||||||||||||
Luteolin |
+
PDE1, Ki: 15.0 μM |
++
PDE2, Ki: 6.4 μM |
+
PDE3, Ki: 13.9 μM |
+
PDE4, Ki: 11.1 μM |
+
PDE5, Ki: 9.5 μM |
98% | |||||||||||||
Milrinone |
++
PDE2, IC50: 5.2 μM |
++
PDE3, IC50: 2.1 μM |
ATPase | 99%+ | |||||||||||||||
Pimobendan |
++
PDE3, IC50: 0.32 μM |
99%+ | |||||||||||||||||
Cilostazol |
++
PDE3, IC50: 0.2 μM |
99%+ | |||||||||||||||||
Fenspiride HCl |
+
PDE3, pIC50: 3.44 |
+
PDE4, pIC50: 4.16 |
99%+ | ||||||||||||||||
(S)-(+)-Rolipram |
++
PDE4, IC50: 0.75 μM |
98% | |||||||||||||||||
Apremilast |
+++
PDE4, IC50: 74 nM |
98% | |||||||||||||||||
GSK256066 |
++++
PDE4B, IC50: 3.2 pM |
98+% | |||||||||||||||||
Roflumilast |
++++
PDE4A4, IC50: 4.3 nM PDE4A1, IC50: 0.7 nM |
99% | |||||||||||||||||
Rolipram |
+++
PDE4B, IC50: 130 nM |
99%+ | |||||||||||||||||
Cilomilast |
+++
LPDE4, IC50: 100 nM HPDE4, IC50: 120 nM |
98+% | |||||||||||||||||
Avanafil |
++++
PDE5, IC50: 1 nM |
99%+ | |||||||||||||||||
Vardenafil HCl Trihydrate |
++++
PDE5, IC50: 0.7 nM |
99%+ | |||||||||||||||||
Tadalafil |
++++
PDE5, IC50: 1.8 nM |
98% | |||||||||||||||||
Icariin |
++
PDE5, IC50: 0.432 μM |
98% | |||||||||||||||||
Sildenafil | ✔ |
+++
PDE6, IC50: 33 nM |
99%+ | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Anagrelide Hydrochloride is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets, and also has been used in the treatment of chronic myeloid leukemia. It inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation[3]. Anagrelide was effective in patients with ET which had similar hematologic remission rate to hydroxyurea and could take effect more quickly than hydroxyurea[4]. Only at anagrelide concentrations of 10 to 500 times therapeutic doses did anagrelide inhibit megakaryocyte colony development: an anagrelide concentration of 5 micrograms/mL reduced colony numbers by 57% and colony size by 31%. Therapeutic concentrations of anagrelide influence primarily the postmitotic phase of megakaryocyte development, decreasing platelet production by reducing megakaryocyte size and ploidy, as well as by disrupting full megakaryocyte maturation[5]. In addition, food/caffeine delayed absorption of anagrelide. Anagrelide was generally well tolerated and had small effects on ECG (electrocardiogram) parameters and heart rate[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00306202 | Leukemia | Phase 1 | Active, not recruiting | October 4, 2022 | Austria ... 展开 >> Local Institution Vienna, Austria, 1090 France Local Institution Nantes, France, 44093 Local Institution Paris Cedex 10, France, 75475 Local Institution Paris Cedex 12, France, 75571 Germany Local Institution Berlin, Germany, 13353 Local Institution Frankfurt, Germany, 60590 Local Institution Hannover, Germany, 30625 Italy Local Institution Monza (mi), Italy, 20052 Netherlands Local Institution Rotterdam, Netherlands, 3015 GJ United Kingdom Local Institution Manchester, Greater Manchester, United Kingdom, M27 4HA Local Institution Bristol, Somerset, United Kingdom, BS2 8BJ Local Institution Sutton, Surrey, United Kingdom, SM2 5PT Local Institution Birmingham, West Midlands, United Kingdom, B4 6NH 收起 << |
NCT01243944 | Polycythemia Vera | Phase 3 | Completed | - | - |
NCT00481052 | Chronic Myeloid Leukemia | Phase 2 | Active, not recruiting | December 2018 | Italy ... 展开 >> Dipartimento Area Medica P.O. Ascoli Piceno, Italy, 63100 Unità Operativa Ematologica - Università degli Studi di Bari Bari, Italy, 70124 Ospedali Riuniti Bergamo, Italy, 24100 stituto di Ematologia "Lorenzo e A. Seragnoli" - Università degli Studi di Bologna - Policlinico S. Orsola - Malpighi Bologna, Italy Sezione di Ematologia e Trapianti Spedali Civili Brescia, Italy, 21125 Azienda Spedali Civili Brescia, Italy, 25100 ASL N.8 - Ospedale "A. Businco" - Struttura Complessa di Ematologia e CTMO Cagliari, Italy Ospedale Ferrarotto Catania, Italy, 95124 Azienda Ospedaliera Pugliese Ciaccio Catanzaro, Italy, 88100 Sezione di Ematologia e Fisiopatologia delle Emostasi - Azienda Ospedaliera - Arcispedale S. Anna Ferrara, Italy Azienda Ospedaliera Universitaria - Università degli Studi di Napoli "Federico II" - Facoltà di Medicina e Chirurgia Napoli, Italy Ospedale S. Luigi Gonzaga Orbassano, Italy, 10043 La Maddalena Casa di Cura di Alta Specialità Dipartimento Oncologico di III Livello Palermo, Italy Unità Operativa Ematologia e Centro Trapianti - Dipartimento di Oncologia ed Ematologia - AUSL Ospedale di Piacenza Piacenza, Italy Ospedale S.Maria delle Croci Ravenna, Italy, 48100 Calabria Dipartimento Emato-Oncologia A.O."Bianchi-Melacrino-Morelli" Reggio Calabria, Italy Università La Cattolica del Sacro Cuore Roma, Italy, 00168 Complesso Ospedaliero S. Giovanni Addolorata Roma, Italy, 00184 Università degli Studi "Sapienza" - Dip Biotecnologie Cellulari ed Ematologia - Divisione di Ematologia Roma, Italy U.O. Ematologia, Azienda Ospedaliera Universitaria Senese Siena, Italy, 53100 Policlinico Universitario - Clinica Ematologia Udine, Italy, 33100 Policlinico G.B. Rossi Verona, Italy, 37134 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.42mL 0.68mL 0.34mL |
17.09mL 3.42mL 1.71mL |
34.18mL 6.84mL 3.42mL |
CAS号 | 58579-51-4 |
分子式 | C10H8Cl3N3O |
分子量 | 292.549 |
别名 | BL4162A;Anagrelide (hydrochloride);Thromboreductin;GALE-401;Xagrid;Agrylin;BMY 26538-01;Anagrelide hydrochloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 6 mg/mL(20.51 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 2% DMSO+water 0.06 mg/mL clear PO 0.5% CMC-Na 54 mg/mL suspension |