Tubercidin, obtained from Streptomyces tubercidicus, is an adenosine analogue, is a nucleoside antibiotic. Also exhibits antifungal and antiviral activities.
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Tubercidin, also known as 7-Deazaadenosine, is an antibiotic derived from Streptomyces tubercidicus. It demonstrates inhibitory action against Streptococcus faecalis, with an IC50 of 0.02 μM[1]. This compound acts by integrating into DNA or RNA, which results in the inhibition of DNA replication, as well as RNA and protein synthesis[2]. Tubercidin is also identified as a mild inhibitor of adenosine phosphorylase, affecting the phosphorylation processes of adenosine and AMP[1]. In a concentration range of 0-10 nM over 14 days, Tubercidin exerts a dose-dependent suppressive effect on both myeloid and erythroid progenitor cells in human bone marrow, with IC50 values of 3.4 nM for CFU-GM and 3.7 nM for BFU-E[3].
Tubercidin 动物研究
Animal study
When administered via intraperitoneal injection at a dosage of 5 mg/kg for 10 days, particularly in conjunction with NBMPR-P, Tubercidin shields mice from its own lethal effects, enabling the treatment to be repeated with a 100% survival rate[3].
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