产品说明书
Tubercidin
 |
同义名 : | 结核菌素 ;7-Deazaadenosine;7-DZA;U 10071;Tubercidine;TBC;Sparsomycin A;SKI 26996;B 120121;Antibiotic XK 101-1;NSC 56408 |
| CAS号 : | 69-33-0 | |
| 货号 : | A118999 | |
| 分子式 : | C11H14N4O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 266.253 | |
| MDL号 : | MFCD00056012 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(112.67 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Tubercidin, also known as 7-Deazaadenosine, is an antibiotic derived from Streptomyces tubercidicus. It demonstrates inhibitory action against Streptococcus faecalis, with an IC50 of 0.02 μM[1]. This compound acts by integrating into DNA or RNA, which results in the inhibition of DNA replication, as well as RNA and protein synthesis[2]. Tubercidin is also identified as a mild inhibitor of adenosine phosphorylase, affecting the phosphorylation processes of adenosine and AMP[1]. In a concentration range of 0-10 nM over 14 days, Tubercidin exerts a dose-dependent suppressive effect on both myeloid and erythroid progenitor cells in human bone marrow, with IC50 values of 3.4 nM for CFU-GM and 3.7 nM for BFU-E[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.76mL 0.75mL 0.38mL |
18.78mL 3.76mL 1.88mL |
37.56mL 7.51mL 3.76mL |
| 参考文献 |
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