Pyridostatin | RR82 | G-quadruplexes Stabilizer | AmBeed-信号通路专用抑制剂

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Pyridostatin {[allProObj[0].p_purity_real_show]}

货号：A280356 同义名： RR82

Pyridostatin is a G-quadruplex-interacting drug which can promote growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.

Pyridostatin 化学结构
CAS号：1085412-37-8

Pyridostatin 3D分子结构
CAS号：1085412-37-8

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Pyridostatin 纯度/质量文件产品仅供科研

货号：A280356 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell Host Microbe, 2024. Ambeed. [ A163338 ]; • Cancer Res., 2024. Ambeed. [ A295334 ]; • J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]; • J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]; • JBC, 2024, 107935. Ambeed. [ A194396 ]; 更多 >

DNA 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							98%
Daptomycin	✔							98%
Blasticidin S·HCl	✔							98%
Metronidazole	✔							98%
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							98+%
Trifluridine	✔							98%
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							98%
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							98%
YK-4-279		✔						99%+
ML216		+ BLM^full-length, IC50: 2.98 μM BLM^636-1298, IC50: 0.97 μM						99%+
RK-33		✔						98%
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				97%
Didox				✔				98%
(E)-3-AP				✔				97%
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, Kd: 42.1 nM Leucyl-tRNA synthetase, IC50: 46.11 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pyridostatin 生物活性

描述

Pyridostatin stabilizes G-quadruplex DNA structures with a dissociation constant (Kd) of 490 nM, leading to growth arrest in human cancer cells by causing DNA damage dependent on both replication and transcription. It specifically targets the Src proto-oncogene, leading to reduced SRC protein levels and decreased SRC-dependent cell movement in human breast cancer cells^[1]^[2].

体外研究

Pyridostatin (10 μM for 48 hours) triggers cell cycle arrest^[1].

As a highly selective G-quadruplex DNA-binding molecule, Pyridostatin stabilizes the G-quadruplex structure, resulting in neurite retraction, loss of synapses, and neuronal death in a dose-dependent manner. It induces double-strand breaks (DSBs) in the DNA of cultured primary neurons. Notably, Pyridostatin treatment (1-5 μM, overnight) reduces BRCA1 protein levels at the transcriptional level, a crucial protein for the maintenance and repair of the neuronal genome[3].

Pyridostatin 参考文献

[1]Rodriguez R, et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012;8(3):301-310. Published 2012 Feb 5.

[2]Koirala D, et al. A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem. 2011;3(10):782-787. Published 2011 Aug 28.

Pyridostatin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.38mL

1.68mL

0.84mL

16.76mL

3.35mL

1.68mL

Pyridostatin 技术信息

CAS号	1085412-37-8
分子式	C₃₁H₃₂N₈O₅
分子量	596.636

别名	RR82
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

动物实验配方

Pyridostatin {[allProObj[0].p_purity_real_show]}

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Pyridostatin {[allProObj[0].p_purity_real_show]}

Pyridostatin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Pyridostatin 质控信息

Pyridostatin 生物活性

Pyridostatin 参考文献

Pyridostatin 实验方案

Pyridostatin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Pyridostatin 纯度/质量文件产品仅供科研