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/ Procarbazine HCl

盐酸甲基苄肼 /Procarbazine HCl {[allProObj[0].p_purity_real_show]}

货号：A775952 同义名： 盐酸丙卡巴肼 / Procarbazine (hydrochloride);NSC-77213 HCl

Procarbazine HCl, an antineoplastic chemotherapy drug, is an alkylating agent for the treatment of Hodgkin's lymphoma and certain brain cancers and also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Procarbazine HCl 化学结构 CAS号：366-70-1
Procarbazine HCl 化学结构
CAS号：366-70-1
Procarbazine HCl 3D分子结构
CAS号：366-70-1
Procarbazine HCl 化学结构 CAS号：366-70-1
Procarbazine HCl 3D分子结构 CAS号：366-70-1
规格 价格 会员价 库存 数量
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Procarbazine HCl 纯度/质量文件 产品仅供科研

货号：A775952 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
• JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]
• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
• J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]
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产品名称 DNA synthesis ↓ helicase ↓ RdRp ↓ ribonucleotide reductase ↓ tRNA synthetase ↓ YB-1 ↓ 其他靶点 纯度
Fexinidazole ✔ 98%
Daptomycin ✔ 98%
Blasticidin S·HCl ✔ 98%
Metronidazole ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Triglycidyl isocyanurate ✔ p53 98+%
Nedaplatin ✔ 99%+
Bendamustine ✔ 98+%
Trifluridine ✔ 98%
Robinetin ✔ 99%+
Carboplatin ✔ 99%
Cidofovir ✔ 99%
Cisplatin ✔ 99%
Cytarabine ++++

DNA synthesis, IC50: 16 nM

 		98%
Acelarin ++++

DNA synthesis, EC50: 0.2 nM

 		99%+
Oxaliplatin ✔ 98%
YK-4-279 ✔ 99%+
ML216 +

BLM636-1298, IC50: 0.97 μM

BLMfull-length, IC50: 2.98 μM

 		99%+
RK-33 ✔ 98%
Brr2-IN-3 ✔ 99%+
Phen-DC3 Trifluoromethanesulfonate ✔ 98%
Favipiravir ✔ 97%
Suramin sodium salt ++

RdRp, IC50: 0.26 μM

 		99%+
Clofarabine ++

Ribonucleotide reductase, IC50: 65 nM

 		97%
Didox ✔ 98%
(E)-3-AP ✔ 97%
Halofuginone +++

prolyl-tRNA synthetase, Ki: 18.3nM

 		99%+
BC-LI-0186 +++

Leucyl-tRNA synthetase, Kd: 42.1 nM

Leucyl-tRNA synthetase, IC50: 46.11 nM

 		98%
SU056 +

YB-1, IC50: 1.73 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Procarbazine HCl 生物活性

描述 Procarbazine Hydrochloride is an alkylating agent, with anticancer activity. Procarbazine is not cytotoxic to the LI 210 cells which lack cytochrome P-450 or monoamine oxidase activity. The azoxy isomers of procarbazine were metabolized in L1210 cells, presumably leading to the DNA or cytotoxic damage observed[3]. At 50 mg kg(-1), procarbazine induced micronuclei in hematopoietic cells, but it did not increase the lacZ mutant frequency (MF) in bone marrow[4]. Mice were orally exposed to PCH (Procarbazine Hydrochloride) (0, 6.25, 12.5, and 25 mg/kg/day) for 28 consecutive days. Blood samples collected 2 days after cessation of treatment exhibited significant dose-related induction of micronuclei in both immature and mature erythrocytes[5]. Procarbazine Hydrochloride (50 mg/kg, i.p.) causes micronuclei in hematopoietic cells, but does not increase the lacZ mutant frequency (MF) in bone marrow of mice, similar to that in liver, testis, spleen, kidney, and lung. Procarbazine Hydrochloride (50 mg/kg, i.p.) has positive effect on lung, bone marrow, and spleen for carcinogenesis[2]. Procarbazine (450 mg/kg) significantly decreases testicular and epididymal weight and drastically reduces haploid cells and spermatogenic arrest in hamster[6].

Procarbazine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00431561 Glioblastoma ... 展开 >>Anaplastic Astrocytoma 收起 << Phase 2 Completed - Austria ... 展开 >> Universitätsklinik Innsbruck; Abteilung für Neurochirurgie Innsbruck, Austria, 6020 Landes-Nervenklinik Wagner-Jauregg Linz, Austria, 4020 Kaiser Franz Josef Spital, Abteilung für Neurologie Wien, Austria, 1100 Georgia Sarajishvili Institute of Clinical Neurology and Neurosurgery Tbilisi, Georgia, 0114 Germany Medizinische Klinik und Poliklinik mit Schwerpunkt Onkologie und Hämatologie, Charité Campus Mitte Berlin, Germany, 10117 Klinik und Poliklinik für Neurologie Cottbus, Germany, 03048 Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden Dresden, Germany, 01307 Universitätsklinikum Gießen, Neurochirurgische Universitätsklinik Gießen, Germany, 35392 Universitätsklinikum Kiel, Klinik für Neurochirurgie Kiel, Germany, 24106 Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurochirurgie Leipzig, Germany, 04103 Universitätsklinik Magdeburg, Klinik für Neurochirurgie Magdeburg, Germany, 39120 Universitätskliniken Mainz, Neurochirurgische Klinik und Poliklinik Mainz, Germany, 55131 Universitätsklinikum Münster, Klinik und Poliklinik für Neurochirurgie Münster, Germany, 48149 Klinikum und Poliklinik für Neurologie, Universität Regensburg Regensburg, Germany, 93053 Klinikum Saarbrücken, Neurochirurgie Saarbrücken, Germany, 66119 Neurologische Universitätsklinik Tübingen Tübingen, Germany, 72076 India Department of Neurosurgery, Amrita Institute of Medical Sciences & Research Centre Cochin, Kerala, India, 682026 Sree Chitra Tirunal Institute for Medical Sciences & Technology, Department of Neurosurgery Trivandrum, Kerala, India, 695011 Manipal Hospital; Manipal Institute for Neurological Disorders Bangalore, India, 560017 Department of Neurosurgery, National Institute of Mental Health and Neurosciences Bangalore, India, 560029 Department of Medical Oncology, Nizam's Institute of Medical Sciences Hyderabad, India, 500082 Department of Neurosurgery, LTMG Hospital & LTM Medical College Mumbai, India, 400022 Department of Neurosurgery, Neurosciences Center New Dehli, India, 110029 Department of Neurological Sciences, Christian Medical College & Hospital Vellore, India, 632004 Israel Soroka Medical Center, Neurosurgery Department Beer Sheva, Israel Rambam Medical Center, Neurosurgery Department Haifa, Israel, 31096 Rabin Medical Center, Neurosurgery Department Petach Tikva, Israel, 49100 Russian Federation Sverdlovsk Regional Oncological Clinic Ekaterinburg, Russian Federation, 620036 Republican Clinical Hospital of Ministry of Health of Tatarstan Republic Kazan, Russian Federation, 420064 Burdenko Neurosurgery Research Institute Moscow, Russian Federation, 125047 Omsk State Medical Academy; State Educational Institution of Higher Professional Education Omsk, Russian Federation, 644099 State Institution of Healthcare, Samara Regional Clinical Hospital in the name of M.I. Kalinin Samara, Russian Federation, 443095 Polenov Neurosurgery Research Institute St. Petersburg, Russian Federation, 191104 Military Medical Academy named after I.S.M. Kirov, Neurosurgery Department St. Petersburg, Russian Federation, 194175 Medical Center "XXI century" St. Petersburg, Russian Federation, 194354 Tcheliabinsk Regional Clinical Hospital; State Medical Institution for Prophylaxis and Treatment Tcheliabinsk, Russian Federation, 454076 收起 <<
NCT00592111 Pediatric Hod... 展开 >>gkin's Disease 收起 << Phase 2 Completed - United States, New York ... 展开 >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT00264953 Hodgkin´s Lymphoma Phase 3 Completed - -

Procarbazine HCl 参考文献

[1]Kraft SL, Baker NM, et al. Procarbazine and antidepressants: a retrospective review of the risk of serotonin toxicity. Psychooncology. 2014 Jan;23(1):108-13.

[2]Ogawa K, Hiraku Y, et al. Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II). Mutat Res. 2003 Aug 5;539(1-2):145-55.

[3]Erikson JM, Tweedie DJ, Ducore JM, Prough RA. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33

[4]Suzuki T, Uno Y, Idehara K, Baba T, Maniwa J, Ohkouchi A, Wang X, Hayashi M, Sofuni T, Tsuruoka M, Miyajima H, Kondo K. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81

[5]Maurice C, Dertinger SD, Yauk CL, Marchetti F. Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig-a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells. Environ Mol Mutagen. 2019 Jul;60(6):505-512

[6]Weissenberg R, Golan R, Shochat L, Lewin LM. Procarbazine effects on spermatogenesis in golden hamster: a flow cytometric evaluation. Arch Androl. 2002 Mar-Apr;48(2):91-100

Procarbazine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.88mL

0.78mL

0.39mL

19.40mL

3.88mL

1.94mL

38.80mL

7.76mL

3.88mL

Procarbazine HCl 技术信息

CAS号366-70-1
分子式C12H20ClN3O
分子量 257.76
别名 盐酸丙卡巴肼 ;Procarbazine (hydrochloride);NSC-77213 HCl;NSC 77213;Natulan;Matulane®;Indicarb;Procarbazine Hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C
溶解度

DMSO: 16 mg/mL(62.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(387.96 mM)，配合低频超声助溶
动物实验配方

Tags: Procarbazine | 366-70-1 | DNA Alkylator/Crosslinker | anticancer activity | Cell Cycle/DNA Damage | DNA Alkylator/Crosslinker | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Procarbazine HCl 纯度/质量文件 | Procarbazine HCl 亚型比较 | Procarbazine HCl 生物活性 | Procarbazine HCl 临床数据 | Procarbazine HCl 参考文献 | Procarbazine HCl 实验方案 | Procarbazine HCl 技术信息

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