Isobavachalcone can induce apoptosis in neuroblastoma, is a chalcone isolated and purified from Angelica keiskei and the fruits of Psoralea corylifolia L.
Isobavachalcone (IBC) is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibited cancer anti-promotive and anti-proliferative activity[3]. Isobavachalcone inhibited massive granulomas, decreased inflammatory cells infiltration and oxidative stress markers level, but it can increase antioxidant enzymes level. Isobavachalcone decreased TNF-α production in BALF and lung tissue. Isobavachalcone can inhibit NF-κB pathway that may be mediated by upregulation of A20. Isobavachalcone can activate NRF2/HO-1 pathway and inhibit adhesion molecule expression[4]. IBC is able to significantly inhibit proliferation and induce apoptosis of Tca8113 (tongue squamous cell carcinoma) cells in vitro. IBC treatment resulted in typical apoptotic morphology of nuclear fragmentation and apoptotic bodies in Tca8113 cells[5].
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