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多西环素 /Doxycycline {[allProObj[0].p_purity_real_show]}

货号:A587145 同义名: 强力霉素 / Vibramycin;Doxiciclina

Doxycycline is an antibiotic that is used in the treatment of various infections caused by bacteria and protozoa.

Doxycycline 化学结构 CAS号:564-25-0
Doxycycline 化学结构
CAS号:564-25-0
Doxycycline 3D分子结构
CAS号:564-25-0
Doxycycline 化学结构 CAS号:564-25-0
Doxycycline 3D分子结构 CAS号:564-25-0
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Doxycycline 纯度/质量文件 产品仅供科研

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Doxycycline 生物活性

靶点
  • MMP

描述 Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline doses commonly used with inducible expression systems (0.01-1 µg/mL) substantially alter cellular metabolism: mitochondrial protein synthesis was inhibited accompanied by reduced oxygen and increased glucose consumption. Furthermore, doxycycline protected human glioma cells from hypoxia-induced cell death. An impairment of cell growth was only detectable with higher doxycycline doses (10 µg/mL)[2]. Doxycycline had a deleterious effect on control groups and positive action for bone organization on female rats affected by bilateral ovariectomy-induced osteopenia and sedentary lifestyle[3]. The treatment with doxycycline and tocopherol alone and in combination significantly attenuated locomotor activity, memory recognition, reduced neuroinflammation, preserved oxidative balance, and restored the level of neurotransmitters[4]. Doxycycline caused certain fetal abnormalities, so it is advisable to avoid using this drug during pregnancy[5].

Doxycycline 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00177333 Abortion, Induced ... 展开 >> Vomiting 收起 << Phase 4 Completed - United States, Pennsylvania ... 展开 >> Magee-Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT02623959 Advanced Cancers ... 展开 >> Malignant Pleural Effusions 收起 << Not Applicable Terminated(Slow Accrual) - United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT03115177 Osteoarthritis Not Applicable Completed - United States, Illinois ... 展开 >> Rush University Medical Center Chicago, Illinois, United States, 60612 收起 <<

Doxycycline 参考文献

[1]Briest W, Cooper TK, Tae HJ, Krawczyk M, McDonnell NB, Talan MI. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7

[2]Luger AL, Sauer B, Lorenz NI, Engel AL, Braun Y, Voss M, Harter PN, Steinbach JP, Ronellenfitsch MW. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504

[3]de Figueiredo FAT, Shimano RC, Ervolino E, Pitol DL, Gerlach RF, Issa JPM. Doxycycline reduces osteopenia in female rats. Sci Rep. 2019 Oct 25;9(1):15316

[4]Rana A, Singh S, Deshmukh R, Kumar A. Pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in rats. Brain Inj. 2020 Jul 2;34(8):1039-1050

[5]Abd-Allah ER, Abd El-Rahman HA. Influence of doxycycline administration on rat embryonic development during organogenesis. J Biochem Mol Toxicol. 2021 Jan;35(1):e2261

Doxycycline 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.25mL

0.45mL

0.23mL

11.25mL

2.25mL

1.13mL

22.50mL

4.50mL

2.25mL

Doxycycline 技术信息

CAS号564-25-0
分子式C22H24N2O8
分子量 444.435
别名 强力霉素 ;Vibramycin;Doxiciclina;Doxycyclinum;Doxytetracycline
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(236.26 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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