货号:A587145
同义名:
强力霉素
/ Vibramycin; Doxiciclina
Doxycycline is an antibiotic that is used in the treatment of various infections caused by bacteria and protozoa.
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描述 | Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline doses commonly used with inducible expression systems (0.01-1 µg/mL) substantially alter cellular metabolism: mitochondrial protein synthesis was inhibited accompanied by reduced oxygen and increased glucose consumption. Furthermore, doxycycline protected human glioma cells from hypoxia-induced cell death. An impairment of cell growth was only detectable with higher doxycycline doses (10 µg/mL)[2]. Doxycycline had a deleterious effect on control groups and positive action for bone organization on female rats affected by bilateral ovariectomy-induced osteopenia and sedentary lifestyle[3]. The treatment with doxycycline and tocopherol alone and in combination significantly attenuated locomotor activity, memory recognition, reduced neuroinflammation, preserved oxidative balance, and restored the level of neurotransmitters[4]. Doxycycline caused certain fetal abnormalities, so it is advisable to avoid using this drug during pregnancy[5]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT00177333 | Abortion, Induced ... 展开 >> Vomiting 收起 << | Phase 4 | Completed | - | United States, Pennsylvania ... 展开 >> Magee-Womens Hospital Pittsburgh, Pennsylvania, United States, 15213 收起 << |
NCT02623959 | Advanced Cancers ... 展开 >> Malignant Pleural Effusions 收起 << | Not Applicable | Terminated(Slow Accrual) | - | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
NCT03115177 | Osteoarthritis | Not Applicable | Completed | - | United States, Illinois ... 展开 >> Rush University Medical Center Chicago, Illinois, United States, 60612 收起 << |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.25mL 0.45mL 0.23mL |
11.25mL 2.25mL 1.13mL |
22.50mL 4.50mL 2.25mL |
CAS号 | 564-25-0 |
分子式 | C22H24N2O8 |
分子量 | 444.43 |
SMILES Code | O=C(C1=C(O)[C@@H](N(C)C)[C@@]([C@@H](O)[C@@]2([H])C(C(C3=C(O)C=CC=C3[C@@H]2C)=O)=C4O)([H])[C@@]4(O)C1=O)N |
MDL No. | MFCD00800994 |
别名 | 强力霉素 ;Vibramycin; Doxiciclina; Doxycyclinum; Doxytetracycline |
运输 | 蓝冰 |
InChI Key | SGKRLCUYIXIAHR-AKNGSSGZSA-N |
Pubchem ID | 54671203 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere, 2-8°C |
溶解方案 |
DMSO: 105 mg/mL(236.26 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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