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贯叶金丝桃素 /Hyperforin {[allProObj[0].p_purity_real_show]}

货号：A688823

Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke.

Hyperforin 化学结构
CAS号：11079-53-1

Hyperforin 3D分子结构
CAS号：11079-53-1

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Hyperforin 纯度/质量文件产品仅供科研

货号：A688823 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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5-羟色胺受体亚型比较

产品名称	5-HT ↓ ↑	5-HT1 ↓ ↑	5-HT2 ↓ ↑	5-HT3 ↓ ↑	5-HT5 ↓ ↑	5-HT6 ↓ ↑	5-HT7 ↓ ↑	其他靶点	纯度
Desvenlafaxine	++ 5-HT, Ki: 40.2 nM								98%
Lamotrigine	+ 5-HT (rat brain synaptosomes), IC50: 474 μM 5-HT (human platelets), IC50: 240 μM								98%
Venlafaxine	✔								98%
Fluvoxamine maleate	✔								99%
Iloperidone	✔								98%
Ziprasidone HCl	✔								98+%
Atomoxetine HCI	+ 5-HT, Ki: 77 nM								98%
Dapoxetine HCl	✔								97%
Trazodone	✔								98+%
Clomipramine HCl	✔								98%
Mirtazapine	✔								99+%
Escitalopram oxalate	+++ 5-HT, Ki: 0.89 nM								97%
Duloxetine	✔								98+%
Sertraline HCl	++ 5-HT, Ki: 13 nM								98%
Citalopram HBr	+++ serotonin reuptake, IC50: 1.8 nM								98%
Latrepirdine 2HCl	✔							GluR	98%
Fluoxetine HCl	✔								99.5%
Paroxetine hydrochloride	✔							AChR	97%
BMY 7378		++ 5-HT1A, pIC50: 6.4 5-HT1D, pIC50: 5.9	+ 5-HT2, pIC50: 5.5						97%
Flibanserin		+++ 5-HT1A, Ki: 1 nM	+ 5-HT2A, Ki: 49 nM						98%
LY310762		+ 5-HT1D, Ki: 249 nM							99%+
Cyclobenzaprine HCI			✔						99%
Blonanserin			+++ 5-HT2, Ki: 3.98 nM						98% HPLC
Cyproheptadine HCl			++++ 5-HT2, IC50: 0.6 nM						99+%
Olanzapine			✔						99+%
Pimavanserin hemitartrate			+++ 5-HT2A, pIC50: 8.7						99%
Ketanserin			+++ 5-HT2C (Rat), Ki: 50 nM 5-HT2C (Human), Ki: 2.5 nM						99%+
Loxapine succinate			++ 5-HT2 (human), Ki: 6.8 nM 5-HT2 (bovine), Ki: 6.6 nM						99%
Agomelatine			✔						98%
Clozapine			✔						98%
Amitriptyline			+ 5-HT2, Ki: 235 nM					SERT	98%
PRX-08066 maleate			+++ 5-HT2B, IC50: 3.4 nM						98+%
RS-127445			++++ 5-HT2B, pIC50: 10.4 5-HT2B, pKi: 9.5						99%+
Sarpogrelate HCl			++++ 5-HT2C, Kd: 1.1 nM 5-HT2A, Kd: 2.1 nM						98%
Tropisetron				✔					99%
Palonosetron				✔					98+%
Ramosetron HCl				++++ 5-HT3 receptor, Ki: 0.091 nM					98%
Ondansetron				✔					99%
Granisetron				✔					98%
Alosetron HCl				✔					98%
Ondansetron hydrochloride dihydrate				✔					98%
VUF10166				++++ 5-HT3A, Ki: 0.04 nM 5-HT3AB, Ki: 22 nM					99%+
Azasetron hydrochloride				++++ 5-HT3, IC50: 0.33 nM					98%
Asenapine maleate		+++ 5-HT1A, pKi: 8.6 5-HT1B, pKi: 8.4	++++ 5-HT2A, pKi: 9.75 5-HT2C, pKi: 10.46		+++ 5-HT5A, pKi: 8.84	++++ 5-HT6, pKi: 9.6	++++ 5-HT7, pKi: 9.94		97%
Risperidone		++ 5-HT1B, Ki: 14.9 nM 5-HT1D, Ki: 84.6 nM	++++ 5-HT2A, Ki: 61.9 nM 5-HT2C, Ki: 12 nM		+ 5-HT5A, Ki: 206 nM		++ 5-HT7, Ki: 6.6 nM		98%
SB 271046 HCl						+++ 5-HT6, pKi: 8.92			99%+
Intepirdine						++++ 5-HT6, pKi: 9.63			99%+
SB-269970 HCl							++ 5-HT7, pKi: 8.3		98+%
BRL 15572		++ 5-HT1D, pKi: 6 5-HT1B, pKi: 6.1	++ 5-HT2B, pKi: 6.2 5-HT2A, pKi: 6.6			+ 5-HT6, pKi: 5.9	+ 5-HT7, pKi: 6.3		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Hyperforin 生物活性

描述	Hyperforin, a pharmacologically active component of the medicinal plant Hypericum perforatum (St. John's wort), has been shown to be neuroprotective against acute ischemic stroke.

Hyperforin 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02505191	Healthy	Phase 1	Completed	-	Germany ... 展开 >> Nuvisan GmbH Neu-Ulm, Germany 收起 <<
NCT01726764	Type 2 Diabetes ... 展开 >> Depression 收起 <<	Phase 1	Completed	-	Denmark ... 展开 >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense, Denmark, DK-5000 收起 <<
NCT01921881	Type 2 Diabetes	Phase 1	Completed	-	Denmark ... 展开 >> Department of Clinical Pharmacology, Institute of Public Health, University of Southern Denmark Odense C, Denmark, DK-5000 收起 <<

Hyperforin 参考文献

[1]Imreova P, Feruszova J, et al. Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells. Molecules. 2017 Jan 21;22(1). pii: E167.

[2]Kwon J, Oh KS, et al. Estrogenic Activity of Hyperforin in MCF-7 Human Breast Cancer Cells Transfected with Estrogen Receptor. Planta Med. 2016 Nov;82(16):1425-1430.

Hyperforin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.63mL

3.73mL

1.86mL

Hyperforin 技术信息

CAS号	11079-53-1
分子式	C₃₅H₅₂O₄
分子量	536.785

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

溶解度

动物实验配方

贯叶金丝桃素 /Hyperforin {[allProObj[0].p_purity_real_show]}

Hyperforin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Hyperforin 质控信息

Hyperforin 生物活性

Hyperforin 临床研究

Hyperforin 参考文献

Hyperforin 实验方案

Hyperforin 技术信息

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贯叶金丝桃素 /Hyperforin {[allProObj[0].p_purity_real_show]}

Hyperforin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Hyperforin 质控信息

Hyperforin 生物活性

Hyperforin 临床研究

Hyperforin 参考文献

Hyperforin 实验方案

Hyperforin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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B

C

F

G

H

J

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Y

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Hyperforin 纯度/质量文件产品仅供科研