哈尔满碱 /Harmane
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货号：A711176
同义名：
1-Methyl-β-Carboline;Aribine
Harmane 是一种β-咔啉生物碱 ，具有显著的神经毒性及MAO A/B抑制活性，适用于研究神经毒性、MAO 抑制和相关生物学过程。
Harmane 化学结构
Harmane 3D分子结构
规格
价格
会员价
库存
数量
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Harmane 纯度/质量文件 产品仅供科研
货号：A711176
标准纯度：
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产品说明书
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Harmane 质控信息
Ivabradine HCl
✔
98%
Maprotiline hydrochloride
✔
98%
Cisatracurium besylate
✔
98%
Yohimbine HCI
✔
99+%
BMY 7378
++
α2C-adrenoceptor, pKi: 6.54
α1D-adrenoceptor, pKi: 5.1
+
β1-adrenoceptor, pIC50: 5.1
97%
Asenapine maleate
++++
α2A-adrenergic receptor, pKi: 8.9
α2B-adrenergic receptor, pKi: 8.9
97%
Piribedil
++
adrenoceptor α2C, pKi: 7.2
adrenoceptor α2A, pKi: 7.1
98%
Prazosin HCl
✔
95%
Silodosin
✔
98%
Phenoxybenzamine HCl
✔
98%
Naftopidil
+++
α1A-adrenergic receptor, Ki: 3.7 nM
α1D-adrenergic receptor, Ki: 20 nM
98%
Naftopidil 2HCl
+
α1-adrenergic receptor, IC50: 0.2 μM
97%
Alfuzosin HCl
✔
98%
Terazosin HCl
✔
99%
Atipamezole
✔
95%
Phentolamine methanesulfonate salt
✔
99%
Doxazosin mesylate
✔
98%
Tolazoline HCl
✔
98%
Zenidolol hydrochloride
++++
β1-adrenergic receptor, Ki: 611nM
β2-adrenergic receptor, Ki: 0.7nM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Harmane 生物活性
描述
Harmane is a β-Carboline alkaloid and a potent neurotoxin that can cause severe action tremors and psychiatric manifestations. It has an IC50 value of 30 nM for the I1-Imidazoline receptor, which is 1000 times more selective than for the α2-adrenoceptor (IC50=18 μM). Harmane is also an effective selective MAO inhibitor, with IC50 values for human MAO A/B of 0.5 μM and 5 μM, respectively. Harmane has comutagenic effect[1] [2] [3] [4]
Harmane 参考文献
Harmane 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
5.49mL
1.10mL
0.55mL
27.44mL
5.49mL
2.74mL
54.88mL
10.98mL
5.49mL
Harmane 技术信息
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