产品说明书

Harmane

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Chemical Structure| 486-84-0 同义名 : 1-Methyl-β-Carboline;Aribine;NSC54439 Passiflorin;NSC 54439;1-Methylnorharman;Passiflorin;Loturine;Locuturin;Locuturine;Aribin;Harman
CAS号 : 486-84-0
货号 : A711176
分子式 : C12H10N2
纯度 : 98%
分子量 : 182.221
MDL号 : MFCD00004957
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(576.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Harmane is a β-Carboline alkaloid and a potent neurotoxin that can cause severe action tremors and psychiatric manifestations. It has an IC50 value of 30 nM for the I1-Imidazoline receptor, which is 1000 times more selective than for the α2-adrenoceptor (IC50=18 μM). Harmane is also an effective selective MAO inhibitor, with IC50 values for human MAO A/B of 0.5 μM and 5 μM, respectively. Harmane has comutagenic effect[1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.44mL

5.49mL

2.74mL

54.88mL

10.98mL

5.49mL
参考文献

[1]Louis ED, et, al. Blood harmane concentrations and dietary protein consumption in essential tremor. Neurology. 2005 Aug 9;65(3):391-6.

[2]Musgrave IF, et, al. Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors. Br J Pharmacol. 2000 Mar;129(6):1057-9.

[3]Glover V, et, al. β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications

[4]Umezawa K, et, al. Comutagenic effect of norharman and harman with 2-acetylaminofluorene derivatives. Proc Natl Acad Sci U S A. 1978 Feb;75(2):928-30.