DiZPK | Photocrosslinker | AmBeed-信号通路专用抑制剂

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DiZPK {[allProObj[0].p_purity_real_show]}

货号：A791385

DiZPK是一种光交联剂，用于鉴定活原核和真核细胞中的直接蛋白质-蛋白质相互作用。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

DiZPK 化学结构
CAS号：1337883-32-5

DiZPK 3D分子结构
CAS号：1337883-32-5

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DiZPK 纯度/质量文件产品仅供科研

货号：A791385 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Adv. Funct. Mater., 2025, 2500696. Ambeed. [ A245395 ]; • JACS, 2025. Ambeed. [ A505336 ]; • Sci. Adv., 2025, 11(13): eadr0006. Ambeed. [ A152627 ]; • ACS Appl. Mater. Interfaces, 2025, 17(12): 18046-18058. Ambeed. [ A739356 , A171817 ]; • Food Res. Int., 2025, 116191. Ambeed. [ A1452012 ]; 更多 >

PDE 亚型比较

产品名称	PDE ↓ ↑	PDE1 ↓ ↑	PDE10A ↓ ↑	PDE2 ↓ ↑	PDE3 ↓ ↑	PDE4 ↓ ↑	PDE5 ↓ ↑	PDE6 ↓ ↑	其他靶点	纯度
Doxofylline	✔									99+%
Deltarasin	+++ PDEδ , Kd: 38 nM									96%
7-(2,3-Dihydroxypropyl)theophylline	✔									98%
Aminophylline	+ PDE, IC50: 0.12 mM									98+%
Anagrelide HCl	✔									99%+
Irsogladine	✔								mAChR,AChR	99%
PF-8380	+++ Autotaxin, IC50: 2.8 nM									99%+
Dipyridamole	✔									98%
Balipodect			++++ PDE10A, IC50: 0.3 nM							99%+
PF-2545920			++++ PDE10A, IC50: 0.37 nM							97%
Luteolin		+ PDE1, Ki: 15.0 μM		++ PDE2, Ki: 6.4 μM	+ PDE3, Ki: 13.9 μM	+ PDE4, Ki: 11.1 μM	+ PDE5, Ki: 9.5 μM			98%
Milrinone				++ PDE2, IC50: 5.2 μM	++ PDE3, IC50: 2.1 μM				ATPase	99%
Pimobendan					++ PDE3, IC50: 0.32 μM					98%
Cilostazol					++ PDE3, IC50: 0.2 μM					98%
Fenspiride HCl					+ PDE3, pIC50: 3.44	+ PDE4, pIC50: 4.16				99% (HPLC)
(S)-(+)-Rolipram						++ PDE4, IC50: 0.75 μM				99% (HPLC)
Apremilast						+++ PDE4, IC50: 74 nM				98%
GSK256066						++++ PDE4B, IC50: 3.2 pM				98+%
Roflumilast						++++ PDE4A1, IC50: 0.7 nM PDE4A4, IC50: 4.3 nM				99%
Rolipram						+++ PDE4B, IC50: 130 nM				99%+
Cilomilast						+++ HPDE4, IC50: 120 nM LPDE4, IC50: 100 nM				99%
Avanafil							++++ PDE5, IC50: 1 nM			98%
Vardenafil HCl Trihydrate							++++ PDE5, IC50: 0.7 nM			98%
Tadalafil							++++ PDE5, IC50: 1.8 nM			98%
Icariin							++ PDE5, IC50: 0.432 μM			98%
Sildenafil							✔	+++ PDE6, IC50: 33 nM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

DiZPK 生物活性

描述

Protein photocrosslinking, via the introduction of non-natural amino acids, has emerged as a superior strategy for the covalent trapping of transient protein-protein interactions in vivo, which is generally not feasible using other methodologies. This method is particularly suitable for detecting periplasmic proteins interacting with HdeA at a low pH. DiZPK, an alkyl diazirine–containing unnatural amino acid, is a new photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells^[2].

作用机制

Introduction of DiZPK at two dimer-interface sites, Phe35 and Ala38, yielded a crosslinking efficiency^[2].

DiZPK 参考文献

[1]Zhang M, Lin S, et al. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nat Chem Biol. 2011 Sep 4;7(10):671-7.

[2]Zhang M, Lin S, Song X, et al. A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance. Nat Chem Biol. 2011;7(10):671‐677

DiZPK 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.50mL

0.70mL

0.35mL

17.52mL

3.50mL

1.75mL

35.05mL

7.01mL

3.50mL

DiZPK 技术信息

CAS号	1337883-32-5
分子式	C₁₂H₂₃N₅O₃
分子量	285.34
SMILES Code	N[C@H](C(O)=O)CCCCNC(NCCCC1(N=N1)C)=O
MDL No.	MFCD28900721

别名
运输	蓝冰
InChI Key	YGUIFRMUMYTGAV-VIFPVBQESA-N
Pubchem ID	53314876

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

细胞实验：

H₂O: 5 mg/mL(17.52 mM)，配合低频超声，并调节pH至7

动物实验：配制的工作液建议现用现配，短期内尽快用完。以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

方案一

DiZPK {[allProObj[0].p_purity_real_show]}

DiZPK 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

DiZPK 质控信息

DiZPK 生物活性

DiZPK 参考文献

DiZPK 实验方案

DiZPK 技术信息

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DiZPK {[allProObj[0].p_purity_real_show]}

DiZPK 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

DiZPK 质控信息

DiZPK 生物活性

DiZPK 参考文献

DiZPK 实验方案

DiZPK 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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B

C

F

G

H

J

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N

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Y

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DiZPK 纯度/质量文件产品仅供科研