DiZPK is a genetically encoded, highly efficient photocrosslinking amino acid valuable in unveiling the physiological interaction partners of given proteins and their functions.
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Protein photocrosslinking, via the introduction of non-natural amino acids, has emerged as a superior strategy for the covalent trapping of transient protein-protein interactions in vivo, which is generally not feasible using other methodologies. This method is particularly suitable for detecting periplasmic proteins interacting with HdeA at a low pH. DiZPK, an alkyl diazirine–containing unnatural amino acid, is a new photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells[2].
作用机制
Introduction of DiZPK at two dimer-interface sites, Phe35 and Ala38, yielded a crosslinking efficiency[2].
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