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/ 组胺受体 / Betahistine EP Impurity C

Betahistine EP Impurity C {[allProObj[0].p_purity_real_show]}

货号：A163510 同义名： NSC19005;Betahistine Impurity C

Betahistine EP Impurity C是一种 H1 受体激动剂和 H3 受体拮抗剂，常用于研究类风湿关节炎 (RA) 和其他过敏性疾病的治疗。

Betahistine EP Impurity C 化学结构 CAS号：5452-87-9
Betahistine EP Impurity C 化学结构
CAS号：5452-87-9
Betahistine EP Impurity C 3D分子结构
CAS号：5452-87-9
Betahistine EP Impurity C 化学结构 CAS号：5452-87-9
Betahistine EP Impurity C 3D分子结构 CAS号：5452-87-9
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Betahistine EP Impurity C 纯度/质量文件 产品仅供科研

货号：A163510 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 99%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		98%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		98%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 98%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 98%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Betahistine EP Impurity C 生物活性

描述 Betahistine EP Impurity C is an impurity of Betahistine[1].Betahistine EP Impurity C is a potent, highly orally active and well tolerated histamine H1 receptor agonist and H3 receptor antagonist used in the study of rheumatoid arthritis (RA)[2][3].Betahistine EP Impurity C inhibited [125I]iodoproxyfan binding on CHO (rH3(445)R) and CHO (hH3(445)R) cell membranes in the range of concentrations less than 10 μM, with IC50 values of 1.9 μM and 3.3 μM, respectively, and Ki values of 1.4 μM and 2.5μM, respectively[3].

Betahistine EP Impurity C 参考文献

[1]Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019

[2]Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.

[3]Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2]  [Content Brief]

Betahistine EP Impurity C 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.72mL

4.14mL

2.07mL

41.44mL

8.29mL

4.14mL

Betahistine EP Impurity C 技术信息

CAS号5452-87-9
分子式C15H19N3
分子量 241.332
别名 NSC19005;Betahistine Impurity C
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月
溶解度
动物实验配方

Tags: Betahistine EP Impurity C | 5452-87-9 | NSC19005 | NSC 19005 | NSC-19005 | Histamine Receptor Modulator | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Histamine Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Betahistine EP Impurity C 纯度/质量文件 | Betahistine EP Impurity C 亚型比较 | Betahistine EP Impurity C 生物活性 | Betahistine EP Impurity C 参考文献 | Betahistine EP Impurity C 实验方案 | Betahistine EP Impurity C 技术信息

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