产品说明书

	同义名 :	NSC19005;Betahistine Impurity C
	CAS号 :	5452-87-9
	货号 :	A163510
	分子式 :	C15H19N3
	纯度 :	97%
	分子量 :	241.332
	MDL号 :	MFCD28157290
	存储条件：	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Betahistine EP Impurity C is an impurity of Betahistine[1].Betahistine EP Impurity C is a potent, highly orally active and well tolerated histamine H1 receptor agonist and H3 receptor antagonist used in the study of rheumatoid arthritis (RA)[2][3].Betahistine EP Impurity C inhibited [125I]iodoproxyfan binding on CHO (rH3(445)R) and CHO (hH3(445)R) cell membranes in the range of concentrations less than 10 μM, with IC50 values of 1.9 μM and 3.3 μM, respectively, and Ki values of 1.4 μM and 2.5μM, respectively[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.14mL 0.83mL 0.41mL	20.72mL 4.14mL 2.07mL	41.44mL 8.29mL 4.14mL

参考文献

[1]Murilo B. M. de Mello, et al. Characterization and in silico Mutagenic Assessment of a New Betahistine Degradation Impurity. J. Braz. Chem. Soc. vol.30 no.7 São Paulo July 2019 Epub July 04, 2019 [2]Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3. [3]Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine[1]. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA)[2]  [Content Brief]