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(R)-(-)-α-Methylhistamine 2HCl
(R)-(-)-α-甲基组胺二盐酸盐 /(R)-(-)-α-Methylhistamine 2HCl
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货号：A676591
同义名：
R-(−)-α-Methylhistamine (hydrochloride);(R)-(-)-α-Methylhistamine dihydrochloride
(R)-(-)-α-Methylhistamine 2HCl 是一种有效、选择性且可透过血脑屏障的 H3 组胺受体激动剂，Kd 值为 50.3 nM，可增强记忆力并减轻大鼠的记忆力障碍。
(R)-(-)-α-Methylhistamine 2HCl 化学结构
CAS号：75614-89-0
(R)-(-)-α-Methylhistamine 2HCl 3D分子结构
CAS号：75614-89-0
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(R)-(-)-α-Methylhistamine 2HCl 纯度/质量文件 产品仅供科研
货号：A676591
标准纯度：
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(R)-(-)-α-Methylhistamine 2HCl 质控信息
| Hydroxyzine 2HCl |
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99+% |
| Cyclizine |
✔
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|
97% |
| Loratadine |
+
|
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|
|
|
98% |
| Desloratadine |
++
Histamine H1 receptor, IC50: 51 nM
|
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|
98% |
| Doxylamine succinate |
✔
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|
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|
99% |
| Ebastine |
✔
|
|
|
|
|
|
98% |
| Tripelennamine HCl |
+
|
|
|
|
|
|
98% |
| Meclizine dihydrochloride |
✔
|
|
|
|
|
|
98% |
| Chlorpheniramine maleate |
+++
Histamine H1 receptor, IC50: 12 nM
|
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|
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|
|
99% |
| Diphenhydramine HCl |
✔
|
|
|
|
|
|
99% |
| Alcaftadine |
++++
|
++
|
|
|
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|
99%+ |
| Fexofenadine HCl |
++
Histamine H1 receptor, IC50: 246 nM
|
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|
99%+ |
| Bilastine |
+++
H1 receptor, Ki: 44.15 nM
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|
98% |
| Pemirolast potassium |
✔
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|
98% |
| Bepotastine besilate |
+
Histamine H1 receptor, pIC50: 5.7
|
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|
98% |
| Mizolastine |
+++
Histamine H1 receptor, IC50: 47 nM
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98% |
| Brompheniramine maleate |
✔
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|
98% |
| Carbinoxamine maleate salt |
✔
|
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|
99+% |
| Clemastine fumarate |
++++
Histamine H1 receptor, IC50: 3 nM
|
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|
|
98% |
| Ketotifen fumarate salt |
✔
|
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|
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|
|
95% |
| Rupatadine Fumarate |
++
Histamine H1 receptor, Ki: 102 nM
|
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|
PAFR
|
98% |
| Famotidine |
|
✔
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|
97% |
| Roxatidine Acetate HCl |
|
+
Histamine H2 receptor, IC50: 3.2 μM
|
|
|
|
|
98% |
| Lafutidine |
|
✔
|
|
|
|
|
99% |
| Cimetidine |
|
✔
|
|
|
|
|
98% |
| Nizatidine |
|
++++
Histamine H2 receptor, IC50: 0.9 nM
|
|
|
|
AChE
|
98% |
| Ranitidine |
|
✔
|
|
|
|
|
98% |
| Betahistine |
|
|
+
Histamine H3 receptor, IC50: 1.9 μM
|
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|
|
98% |
| Ciproxifan maleate |
|
|
+++
Histamine H3 receptor, IC50: 9.2 nM
|
|
|
|
99%+ |
| S 38093 |
|
|
++
rat H3 receptor, Ki: 1.44 μM
human H3 receptor, Ki: 1.2 μM
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|
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|
98% |
| JNJ-7777120 |
|
|
|
++++
Histamine H4 receptor, Ki: 4.5 nM
|
|
|
98% |
| Azelastine HCl |
|
|
|
|
✔
|
|
98% |
| Epinastine HCl |
|
|
|
|
✔
|
|
98% |
| Levodropropizine |
|
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|
|
✔
|
|
97% |
| Cyproheptadine hydrochloride |
|
|
|
|
✔
|
|
98% |
| Hesperetin |
|
|
|
|
✔
|
|
97% |
| Olopatadine HCl |
|
|
|
|
✔
|
|
98% |
| Mianserin hydrochloride |
|
|
|
|
✔
|
|
99+% |
| Buclizine 2HCl |
|
|
|
|
✔
|
|
97% |
| Latrepirdine 2HCl |
|
|
|
|
✔
|
GluR
|
98% |
| Cetirizine 2HCl |
|
|
|
|
✔
|
|
98% |
|
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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(R)-(-)-α-Methylhistamine 2HCl 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
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1 mM
5 mM
10 mM
|
5.05mL
1.01mL
0.50mL
|
25.24mL
5.05mL
2.52mL
|
50.48mL
10.10mL
5.05mL
|
(R)-(-)-α-Methylhistamine 2HCl 技术信息
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