In isolated guinea pig left atria, NSP-805 exhibits a positive inotropic EC50 value with a potency order of 0.18 μM. The in vitro positive inotropic effects of NSP-805 are accompanied by increases in tissue cyclic AMP and are abolished by carbachol[1].
体内研究
In anesthetized dogs, intravenous (i.v.) administration of NSP-805 leads to dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively slight increases in heart rate (HR). The ED50 value for LVdP/dtmax of NSP-805 is 12 μg/kg. When administered intraduodenally to anesthetized dogs, the ED50 value for LVdP/dtmax of NSP-805 is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely restores the hemodynamic state of heart failure to normal levels[1].
NSP-805 (100 μg/kg) significantly reduces systemic blood pressure, but the increase in chorio-retinal blood flow is lower than that observed with the low dose of NSP-805 (40 μg/kg) in rabbit eyes[2].
体外研究
In isolated guinea pig left atria, NSP-805 exhibits a positive inotropic EC50 value with a potency order of 0.18 μM. The in vitro positive inotropic effects of NSP-805 are accompanied by increases in tissue cyclic AMP and are abolished by carbachol[1].
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