货号:A531870 同义名: TSA TFA;Tubastatin A (trifluoroacetate salt)
Tubastatin A (TSA) TFA是一种高效、选择性的 HDAC6 抑制剂,在无细胞试验中的 IC50 为 15 nM,相对于所有其他同工酶具有 1000 倍的选择性,除 HDAC8 (57 倍)。TSA TFA 还抑制 HDAC10 和金属-β-内酰胺酶结构域蛋白 2 (MBLAC2)。
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产品名称 | Autophagy ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SBI-0206965 |
+++
ULK1, IC50: 108 nM ULK2, IC50: 711 nM |
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Hydroxychloroquine sulfate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Valproic acid sodium | ✔ | HDAC | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
PFK-015 |
++
PFKFB3, IC50: 207 nM |
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MRT68921 hydrochloride |
++++
ULK1, IC50: 2.9 nM ULK2, IC50: 1.1 nM |
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ROC-325 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Autophinib |
+++
Autophagy, IC50: 40 nM |
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Lys05 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | HD1 ↓ ↑ | HD2 ↓ ↑ | HDAC ↓ ↑ | HDAC1 ↓ ↑ | HDAC10 ↓ ↑ | HDAC11 ↓ ↑ | HDAC2 ↓ ↑ | HDAC3 ↓ ↑ | HDAC4 ↓ ↑ | HDAC5 ↓ ↑ | HDAC6 ↓ ↑ | HDAC7 ↓ ↑ | HDAC8 ↓ ↑ | HDAC9 ↓ ↑ | 其他靶点 | 纯度 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Givinostat HCl monohydrate |
++++
HD1-B, IC50: 7.5 nM HD1-A, IC50: 16 nM |
+++
HD2, IC50: 10 nM |
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MC1568 |
++
HD1-B (Maize), IC50: 3.4 μM HD1-A (Maize), IC50: 100 nM |
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Trichostatin A |
++++
HDAC, IC50: ~1.8 nM |
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Scriptaid | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Valproic acid sodium | ✔ | Autophagy | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
AR-42 |
+++
HDAC, IC50: 30 nM |
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Dacinostat |
+++
HDAC, IC50: 32 nM |
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CUDC-101 |
++++
HDAC, IC50: 4.4 nM |
++++
HDAC1, IC50: 4.5 nM |
+++
HDAC10, IC50: 26.1 nM |
+++
HDAC2, IC50: 12.6 nM |
++++
HDAC3, IC50: 9.1 nM |
+++
HDAC4, IC50: 13.2 nM |
+++
HDAC5, IC50: 11.4 nM |
++++
HDAC6, IC50: 5.1 nM |
+
HDAC7, IC50: 373 nM |
++
HDAC8, IC50: 79.8 nM |
++
HDAC9, IC50: 67.2 nM |
HER2,EGFR | {[allProObj[0].p_purity_real_show]} | ||||||
M344 |
++
HDAC, IC50: 100 nM |
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Splitomicin |
+
Sir2p, IC50: 60 μM |
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Panobinostat |
++++
HDAC (Reh cells), IC50: 20 nM HDAC (MOLT-4 cells), IC50: 5 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sodium 4-Phenylbutyrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Vorinostat |
+++
HDAC, IC50: ~10 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Curcumin | ✔ | NF-κB,Nrf2 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Belinostat |
+++
HDAC, IC50: 27 nM |
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RG-2833 |
++
HDAC1, Ki: 32 nM |
++
HDAC3, Ki: 5 nM |
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Valproic acid |
+
HDAC1, IC50: 0.4 mM |
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BG45 |
+
HDAC1, IC50: 2 μM |
+
HDAC2, IC50: 2.2 μM |
+
HDAC3, IC50: 289 nM |
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Entinostat |
+
HDAC1, IC50: 0.51 μM |
+
HDAC3, IC50: 1.7 μM |
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Resminostat |
+++
HDAC1, IC50: 42.5 nM |
++
HDAC3, IC50: 50.1 nM |
++
HDAC6, IC50: 71.8 nM |
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Romidepsin |
+++
HDAC1, IC50: 36 nM |
+++
HDAC2, IC50: 47 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Parthenolide | ✔ | p53,NF-κB | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Tacedinaline |
+
HDAC1, IC50: 0.9 μM |
+
HDAC2, IC50: 0.9 μM |
+
HDAC3, IC50: 1.2 μM |
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Mocetinostat |
++
HDAC1, IC50: 0.15 μM |
+
HDAC11, IC50: 0.59 μM |
+
HDAC2, IC50: 0.29 μM |
+
HDAC3, IC50: 1.66 μM |
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WT-161 |
++++
HDAC1, IC50: 8.35 nM |
+++
HDAC2, IC50: 15.4 nM |
++++
HDAC6, IC50: 0.4 nM |
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Fimepinostat |
++++
HDAC1, IC50: 1.7 nM |
++++
HDAC10, IC50: 2.8 nM |
++++
HDAC11, IC50: 5.4 nM |
++++
HDAC2, IC50: 5.0 nM |
++++
HDAC3, IC50: 1.8 nM |
+++
HDAC6, IC50: 27 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||
Tucidinostat |
++
HDAC1, IC50: 95 nM |
++
HDAC10, IC50: 78 nM |
++
HDAC2, IC50: 160 nM |
++
HDAC3, IC50: 67 nM |
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Santacruzamate A |
++++
HDAC2, IC50: 119 pM |
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(E,E)-RGFP966 |
++
HDAC3, IC50: 80 nM |
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LMK-235 |
+++
HDAC4, IC50: 11.9 nM |
++++
HDAC5, IC50: 4.2 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Tasquinimod | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CAY10603 |
++++
HDAC6, IC50: 2 pM |
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Tubastatin A |
+++
HDAC6, IC50: 15 nM |
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Tubacin |
++++
HDAC6, IC50: 4 nM |
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ACY-738 |
++++
HDAC6, IC50: 1.7 nM |
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Nexturastat A |
++++
HDAC6, IC50: 5 nM |
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BRD73954 |
+++
HDAC6, IC50: 36 nM |
++
HDAC8, IC50: 120 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Tubastatin A HCl |
+++
HDAC6, IC50: 15 nM |
+
HDAC8, IC50: 854 nM |
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PCI-34051 |
+++
HDAC8, IC50: 10 nM |
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Ricolinostat |
++
HDAC1, IC50: 58 nM |
++
HDAC2, IC50: 48 nM |
++
HDAC3, IC50: 51 nM |
++++
HDAC6, IC50: 4.7 nM |
++
HDAC8, IC50: 100 nM |
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Droxinostat |
+
HDAC3, IC50: 16.9 μM |
+
HDAC6, IC50: 2.47 μM |
+
HDAC8, IC50: 1.46 μM |
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Abexinostat |
++++
HDAC1, Ki: 7 nM |
+++
HDAC10, IC50: 24 nM |
+++
HDAC2, Ki: 19 nM |
++++
HDAC3/SMRT, Ki: 8.2 nM |
+++
HDAC6, Ki: 17 nM |
+
HDAC8, IC50: 280 nM |
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Citarinostat |
+++
HDAC1, IC50: 35 nM |
+++
HDAC2, IC50: 45 nM |
+++
HDAC3, IC50: 46 nM |
++++
HDAC6, IC50: 2.6 nM |
++
HDAC8, IC50: 137 nM |
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HPOB |
+
HDAC1, IC50: 2.9 μM |
+
HDAC10, IC50: 3.0 μM |
+
HDAC2, IC50: 4.4 μM |
+
HDAC3, IC50: 1.7 μM |
++
HDAC6, IC50: 56 nM |
+
HDAC8, IC50: 2.8 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||
Quisinostat 2HCl |
++++
HDAC1, IC50: 0.11 nM |
++++
HDAC10, IC50: 0.46 nM |
++++
HDAC11, IC50: 0.37 nM |
++++
HDAC2, IC50: 0.33 nM |
++++
HDAC3, IC50: 4.86 nM |
++++
HDAC4, IC50: 0.64 nM |
++++
HDAC5, IC50: 3.69 nM |
++++
HDAC8, IC50: 4.26 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||
Domatinostat |
+
HDAC1, IC50: 1.20 μM |
+
HDAC10, IC50: 21 μM |
+
HDAC11, IC50: 9.7 μM |
+
HDAC2, IC50: 1.12 μM |
+
HDAC3, IC50: 0.57 μM |
+
HDAC5, IC50: 11.3 μM |
+
HDAC9, IC50: 50 μM |
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TMP269 |
++
HDAC4, IC50: 157 nM |
++
HDAC5, IC50: 97 nM |
+++
HDAC7, IC50: 43 nM |
+++
HDAC9, IC50: 23 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
Pracinostat |
++
HDAC1, IC50: 49 nM |
+++
HDAC10, IC50: 40 nM |
++
HDAC11, IC50: 93 nM |
++
HDAC2, IC50: 96 nM |
+++
HDAC3, IC50: 43 nM |
++
HDAC4, IC50: 56 nM |
+++
HDAC5, IC50: 47 nM |
+
HDAC6, IC50: 1.008 μM |
++
HDAC7, IC50: 137 nM |
++
HDAC8, IC50: 140 nM |
++
HDAC9, IC50: 70 nM |
{[allProObj[0].p_purity_real_show]} | |||||||
TMP195 |
++
HDAC4, Ki: 59 nM |
++
HDAC5, Ki: 60 nM |
+++
HDAC7, Ki: 26 nM |
+++
HDAC9, Ki: 15 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | Capase-7 ↓ ↑ | Caspase ↓ ↑ | Caspase-1 ↓ ↑ | Caspase-10 ↓ ↑ | Caspase-2 ↓ ↑ | Caspase-3 ↓ ↑ | Caspase-4 ↓ ↑ | Caspase-5 ↓ ↑ | Caspase-6 ↓ ↑ | Caspase-8 ↓ ↑ | Caspase-9 ↓ ↑ | 其他靶点 | 纯度 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Emricasan | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Z-VAD(OMe)-FMK | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Z-VAD-FMK | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Q-VD-OPh | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||||
VX-765 |
++++
Caspase-1, Ki: 0.8 nM |
++++
Caspase-4, Ki: <0.6 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Ac-DEVD-CHO |
+++
caspase-7, Ki: 1.6 nM |
+++
Caspase-1, Ki: 18 nM |
+++
caspase-10, Ki: 12 nM |
+
caspase-2, Ki: 1.71 μM |
++++
Caspase-3, Ki: 230 pM |
++
Caspase-4, Ki: 132 nM |
++
caspase-5, Ki: 205 nM |
+++
caspase-6, Ki: 31 nM |
++++
caspase-8, Ki: 0.92 nM |
++
Caspase-9, Ki: 60 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||
Z-DEVD-FMK | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Z-IETD-FMK | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Tubastatin A exhibits significant selectivity towards all 11 HDAC isoforms, maintaining over 1000-fold selectivity against all isoforms except HDAC8, for which it demonstrates approximately 57-fold selectivity. In assays assessing homocysteic acid (HCA)-induced neurodegeneration, Tubastatin A demonstrates dose-dependent protection against HCA-induced neuronal cell death, with significant protection observed at 5 μM and near-complete protection at 10 μM[1]. Treatment of CC12 cells with Tubastatin A results in impaired myotube formation when alpha-tubulin undergoes early hyperacetylation during the myogenic process; however, myotube elongation occurs when alpha-tubulin is hyperacetylated in mature myotubes[3]. A recent study suggests that treatment with Tubastatin A enhances cell elasticity, as demonstrated by atomic force microscopy (AFM) tests, without causing significant alterations to the actin microfilament or microtubule networks in mouse ovarian cancer cell lines, MOSE-E and MOSE-L[4]. |
体内研究 | Daily administration of Tubastatin A at a dose of 0.5 mg/kg suppresses HDAC6, thereby enhancing the suppressive function of Tregs in mouse models of inflammation and autoimmunity, including various experimental colitis models and fully major histocompatibility complex (MHC)-incompatible cardiac allograft rejection[2]. |
体外研究 | Tubastatin A exhibits significant selectivity towards all 11 HDAC isoforms, maintaining over 1000-fold selectivity against all isoforms except HDAC8, for which it demonstrates approximately 57-fold selectivity. In assays assessing homocysteic acid (HCA)-induced neurodegeneration, Tubastatin A demonstrates dose-dependent protection against HCA-induced neuronal cell death, with significant protection observed at 5 μM and near-complete protection at 10 μM[1]. Treatment of CC12 cells with Tubastatin A results in impaired myotube formation when alpha-tubulin undergoes early hyperacetylation during the myogenic process; however, myotube elongation occurs when alpha-tubulin is hyperacetylated in mature myotubes[3]. A recent study suggests that treatment with Tubastatin A enhances cell elasticity, as demonstrated by atomic force microscopy (AFM) tests, without causing significant alterations to the actin microfilament or microtubule networks in mouse ovarian cancer cell lines, MOSE-E and MOSE-L[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.23mL 0.45mL 0.22mL |
11.13mL 2.23mL 1.11mL |
22.25mL 4.45mL 2.23mL |
CAS号 | 1239262-52-2 |
分子式 | C22H22F3N3O4 |
分子量 | 449.423 |
别名 | TSA TFA;Tubastatin A (trifluoroacetate salt);Tubastatin A trifluoroacetate salt |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 | |
动物实验配方 |