Z-DEVD-FMK | Caspase-3 Inhibitor | Caspase-3 Inhibitor | AmBeed-信号通路专用抑制剂

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Z-DEVD-FMK 98%

货号：A301584 同义名： Caspase-3 Inhibitor

Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner.

Z-DEVD-FMK 化学结构
CAS号：210344-95-9

Z-DEVD-FMK 3D分子结构
CAS号：210344-95-9

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Z-DEVD-FMK 纯度/质量文件产品仅供科研

货号：A301584 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

半胱天冬酶亚型比较

产品名称	Capase-7 ↓ ↑	Caspase ↓ ↑	Caspase-1 ↓ ↑	Caspase-10 ↓ ↑	Caspase-2 ↓ ↑	Caspase-3 ↓ ↑	Caspase-4 ↓ ↑	Caspase-5 ↓ ↑	Caspase-6 ↓ ↑	Caspase-8 ↓ ↑	Caspase-9 ↓ ↑	纯度
Emricasan		✔										99%+
Z-VAD(OMe)-FMK		✔										99%+
Z-VAD-FMK		✔										99%+
Q-VD-OPh												97%
VX-765			++++ Caspase-1, Ki: 0.8 nM				++++ Caspase-4, Ki: <0.6 nM					99%+
Ac-DEVD-CHO	+++ caspase-7, Ki: 1.6 nM		+++ Caspase-1, Ki: 18 nM	+++ caspase-10, Ki: 12 nM	+ caspase-2, Ki: 1.71 μM	++++ Caspase-3, Ki: 230 pM	++ Caspase-4, Ki: 132 nM	++ caspase-5, Ki: 205 nM	+++ caspase-6, Ki: 31 nM	++++ caspase-8, Ki: 0.92 nM	++ Caspase-9, Ki: 60 nM	98%+
Z-DEVD-FMK						✔						98%
Z-IETD-FMK										✔		98%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Z-DEVD-FMK 生物活性

靶点	Caspase-3
描述	Z-DEVD-FMK is an irreversible caspase-3 inhibitor with specificity, having an IC50 of 18 μM^[1].
体内研究	Early treatment with Z-DEVD-FMK (160 ng) enhances motor and cognitive function following traumatic CNS injury induced by severe controlled cortical impact (CCI) in mice^[2]. Treatment with Z-DEVD-FMK (160 ng) significantly enhances neurological outcomes compared to traumatized animals treated with DMSO vehicle (p<0.01)^[3].
体外研究	N27 cells are treated with MPP⁺ alone or with 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, or 50 μM Z-LEHD-FMK. Caspase-9 and caspase-3 enzymatic activities are assessed after 12 and 24 hours of exposure, respectively. Exposure to 300 μM MPP⁺ for 24 hours increases caspase-3 enzyme activity by approximately 2.5-fold in N27 cells. The MPP⁺-induced elevation in caspase-3 enzyme activity is significantly attenuated by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK^[1].

Z-DEVD-FMK 参考文献

[1]Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's disease models. Free Radic Biol Med. 2006 Nov

[2]Knoblach SM, et al. Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 2004 Oct;24(10):1119-32.

[3]Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424.

Z-DEVD-FMK 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.50mL

0.30mL

0.15mL

7.48mL

1.50mL

0.75mL

14.96mL

2.99mL

1.50mL

Z-DEVD-FMK 技术信息

CAS号	210344-95-9
分子式	C₃₀H₄₁FN₄O₁₂
分子量	668.665

别名	Caspase-3 Inhibitor
运输	蓝冰

存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(74.78 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

2% DMSO+30% PEG 400+5% Tween 80+water 1 mg/mL

Z-DEVD-FMK 98%

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Z-DEVD-FMK 98%

Z-DEVD-FMK 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Z-DEVD-FMK 质控信息

Z-DEVD-FMK 生物活性

Z-DEVD-FMK 参考文献

Z-DEVD-FMK 实验方案

Z-DEVD-FMK 技术信息

最近浏览的产品

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摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Z-DEVD-FMK 纯度/质量文件产品仅供科研