Rifapentine is an antibiotic compound used in the treatment of tuberculosis. Antibacterial Rifapentine inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme[3]. The 3-month isoniazid-rifapentine regimen is as safe and effective as other recommended latent tuberculosis infection regimens and achieves significantly higher treatment completion rates[4]. Indeed, rifapentine too may decrease blood levels of many oral antidiabetics and compete with them for protein-binding sites and/or transporters. Rifapentine seems to be more suitable for use in diabetes patients with renal impairment, owing to the fact that it does not cause renal toxicity, and it is eliminated via kidneys in smaller proportions than rifampicin[5]. Rifapentine can be administered twice weekly during the intensive phase of tuberculosis treatment and then once weekly during the continuation phase of treatment. Rifapentine is well tolerated, with most patients experiencing adverse effects at a similar rate as rifampin[6].
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
Philippines
... 展开 >> De La Salle Health Sciences Institute
Not yet recruiting
Manila, Philippines
Lung Center Philippines
Recruiting
Manila, Philippines
Philippines Tuberculosis Society Incorporated (PTSI)
Not yet recruiting
Manila, Philippines
Tropical Disease Foundation
Not yet recruiting
Manila, Philippines
Singapore
National University Hospital
Not yet recruiting
Singapore, Singapore
Thailand
King Chulalongkorn Memorial Hospital
Not yet recruiting
Bangkok, Thailand 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
Philippines
... 展开 >> De La Salle Health Sciences Institute
Not yet recruiting
Manila, Philippines
Lung Center Philippines
Recruiting
Manila, Philippines
Philippines Tuberculosis Society Incorporated (PTSI)
Not yet recruiting
Manila, Philippines
Tropical Disease Foundation
Not yet recruiting
Manila, Philippines
Singapore
National University Hospital
Not yet recruiting
Singapore, Singapore
Thailand
King Chulalongkorn Memorial Hospital
Not yet recruiting
Bangkok, Thailand 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
United States, California
... 展开 >>
University of California, San Francisco
San Francisco, California, United States, 94110
United States, Colorado
Denver Public Health Department
Denver, Colorado, United States, 80204
United States, District of Columbia
Washington DC Veterans Affairs Medical Center
Washington, District of Columbia, United States, 20422
United States, New York
Columbia University College of Physicians and Surgeons and New York City Department of Health
New York, New York, United States, 10032
United States, North Carolina
Duke University
Durham, North Carolina, United States, 27713
United States, Tennessee
Vanderbilt University Medical Center and Nashville Metro Public Health Department
Nashville, Tennessee, United States, 37232-0146
United States, Texas
University of North Texas Health Science Center at Fort Worth
Fort Worth, Texas, United States, 76104-4802
Audie L. Murphy VA Hospital
San Antonio, Texas, United States, 78229-4404
South Texas - Department of State Health Services
San Antonio, Texas, United States, 78229-4404
China
TB and Chest service of Hong Kong
Hong Kong, China
South Africa
Wits Health Consortium
Soweto, South Africa
Spain
Agencia de Salut Publica - Barcelona, Spain and UNTHSC
Barcelona, Spain, 08023 收起 <<
South Africa
... 展开 >> Centre for the Aids Programme of Research in South Africa (CAPRISA)
Durban, KwaZulu-Natal, South Africa, 4013
Aurum Institute
Klerksdorp, North West Province, South Africa, 2571
Aurum Institute
Rustenburg, North West, South Africa, 0300
Stellenbosch Immunology Research Group
Cape Town, Western Cape, South Africa, 7505
South African Tuberculosis Vaccine Initiative (SATVI)
Worcester, Western Cape, South Africa, 6850 收起 <<
Respiratory Tract Infections
... 展开 >> HIV Infections 收起 <<
Phase 1
Phase 2
Recruiting
November 3, 2018
South Africa
... 展开 >> The Aurum Institute: Tembisa Clinical Research Centre
Recruiting
Tembisa, Gauteng, South Africa, 1736
Contact: Modulakgotla Sebe, BCh, MB 27-87-1351645 msebe@auruminstitute.org 收起 <<
Haiti
... 展开 >> Les Centres GHESKIO Clinical Research Site (GHESKIO-INLR) CRS
Port-au-Prince, Haiti, HT-6110
Kenya
Kenya Medical Research Institute / Walter Reed Project Clinical Research Center, Kericho CRS
Kericho, Kenya, 20200
Malawi
Malawi CRS
Lilongwe, Central Malawi, Malawi
Thailand
Siriraj Hospital ,Mahidol University NICHD CRS
Bangkok, Bangkoknoi, Thailand, 10700
Zimbabwe
Harare Family Care CRS
Harare, Zimbabwe 收起 <<
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
United States, California
... 展开 >>
San Diego County Health and Human Services Agency
Recruiting
San Diego, California, United States, 92110
Contact: Wilma J Wooten, M.D., M.P.H 619-515-6597 Wilma.Wooten@sdcounty.ca.gov
Contact: Antonette Antonio, NP, RN 619-692-5718 Antonette.Antonio@sdcounty.ca.gov 收起 <<
United States, California
... 展开 >>
UCSD Antiviral Research Center CRS
San Diego, California, United States, 92103
United States, Maryland
Johns Hopkins University CRS
Baltimore, Maryland, United States, 21205
United States, North Carolina
Chapel Hill CRS
Chapel Hill, North Carolina, United States, 27599
United States, Tennessee
Vanderbilt Therapeutics (VT) CRS
Nashville, Tennessee, United States, 37204 收起 <<
Brazil
... 展开 >> Centro de Referência Professor Hélio Fraga - ENSP - FIOCRUZ
Curicica, Rio de Janeiro, Brazil, 22.780-192
Posto de Saude Albert Sabin
Rio de Janeiro, RJ, Brazil, 20211-110
Hospital Universitario Clementio Fraga Filho
Rio de Janeiro, Brazil 收起 <<
United States, Texas
... 展开 >>
Audie L Murphy Veterans Administration Hospital
San Antonio, Texas, United States, 78229
University of Texas Health Science Center
San Antonio, Texas, United States, 78229 收起 <<
United States, Colorado
... 展开 >>
Denver Public Health
Denver, Colorado, United States
United States, Texas
University of North Texas
Denton, Texas, United States
TBTC site 40 / South Texas
Harlingen, Texas, United States
Audie L. Murphy VA Medical Center
San Antonio, Texas, United States
South Africa
University of KwaZulu Natal
Durban, South Africa
Uganda
Uganda / Case Western Reserve Research Collaboration
Kampala, Uganda 收起 <<
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