Isoliquiritigenin | GU17;ISL;GU 17, Isoliquiritigenin;4,2',4'-Trihydroxychalcone;ILQ;SJ000286237;Isoliquiritigen | Plant Standard | Sirtuin | Aldose Reductase

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异甘草素 /Isoliquiritigenin {[allProObj[0].p_purity_real_show]}

货号：A289179 同义名： GU17;ISL

Isoliquiritigenin是一种从甘草根中提取的抗肿瘤黄酮类化合物，以 320 nM 的 IC50 抑制醛糖还原酶，并以 24.7 μM 的 EC50 抑制流感病毒复制。

Isoliquiritigenin 化学结构
CAS号：961-29-5

Isoliquiritigenin 3D分子结构
CAS号：961-29-5

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Isoliquiritigenin 纯度/质量文件产品仅供科研

货号：A289179 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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Sirtuin 亚型比较

产品名称	SIRT1 ↓ ↑	SIRT2 ↓ ↑	SIRT3 ↓ ↑	SIRT5 ↓ ↑	SIRT6 ↓ ↑	SIRT7 ↓ ↑	Sirtuin ↓ ↑	其他靶点	纯度
Selisistat	++++ SIRT1, IC50: 38 nM								99%+
Resveratrol	✔								98%
Inauhzin	✔							p53	99%+
Suramin sodium salt	+++ SirT1, IC50: 297 nM			++ SirT5, IC50: 22 μM					99%+
Salermide	✔								98%
Quercetin Dihydrate	✔								95%
Sirtinol	+ SIRT1, IC50: 131 μM	++ SIRT2, IC50: 38 μM							98%+
AGK2		+++ SIRT2, IC50: 3.5 μM							99%+
Tenovin-3		✔						p53	99%+
3-TYP	++++ SIRT1, IC50: 88 nM	++++ SIRT2, IC50: 92 nM	++++ SIRT3, IC50: 16 nM						95%
Tenovin-6	++ SIRT1, IC50: 21 μM	++ SIRT2, IC50: 10 μM	+ SIRT3, IC50: 67 μM					p53	99%+
SirReal2		+++ SIRT2, IC50: 140 nM							99%+
Thiomyristoyl		++++ SIRT2, IC50: 28 nM							99%+
Et-29				✔					98%
OSS_128167	+ SIRT1, IC50: 1578 μM	+ SIRT2, IC50: 751 μM			+ SIRT6, IC50: 89 μM				98%
SIRT7 inhibitor 97491						+++ SIRT7, IC50: 325 nM			97%
Nicotinamide							✔		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Isoliquiritigenin 生物活性

描述

Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco^[3]. Isoliquiritigenin inhibited rat lens aldose reductase with an IC50 of 3.2 x 10(-7) M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells, with an IC50 of 2.0 x 10(-6) M^[4]. Isoliquiritigenin treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. Moreover, Isoliquiritigenin reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes^[3]. Isoliquiritigenin also showed the most potent inhibition of mouse rectal contraction induced by CCh(carbamylcholine) with an IC50 value of 1.70+/-0.07 microM^[5].

Isoliquiritigenin 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
CHO cells		Cytotoxicity assay		Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM	19572738
colon 26-L5 cells		Cytotoxicity assay	72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM	18440233
dog MDCK cells	20 ug/mL	Function assay	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control	22743086
dog MDCK cells		Function assay	8 h	Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence	22743086

Isoliquiritigenin 参考文献

[1]Nerya O, Vaya J, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7.

[2]Aida K, Tawata M, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.

[3]Zhang X, Zhu P, Zhang X, Ma Y, Li W, Chen JM, Guo HM, Bucala R, Zhuang J, Li J. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. doi: 10.1155/2013/390890. Epub 2013 Sep 16. PMID: 24163504; PMCID: PMC3791876.

[4]Aida K, Tawata M, Shindo H, Onaya T, Sasaki H, Yamaguchi T, Chin M, Mitsuhashi H. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. doi: 10.1055/s-2006-960950. PMID: 2118267.

[5]Sato Y, He JX, Nagai H, Tani T, Akao T. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. doi: 10.1248/bpb.30.145. PMID: 17202675.

Isoliquiritigenin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.90mL

0.78mL

0.39mL

19.51mL

3.90mL

1.95mL

39.02mL

7.80mL

3.90mL

Isoliquiritigenin 技术信息

CAS号	961-29-5
分子式	C₁₅H₁₂O₄
分子量	256.253

别名	GU17;ISL;GU 17, Isoliquiritigenin;4,2',4'-Trihydroxychalcone;ILQ;SJ000286237;Isoliquiritigen
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(409.75 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(390.24 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

CHO cells		Cytotoxicity assay		Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM	19572738
colon 26-L5 cells		Cytotoxicity assay	72 h	Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM	18440233
dog MDCK cells	20 ug/mL	Function assay	1 h	Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control	22743086
dog MDCK cells		Function assay	8 h	Inhibition of PKC/p38MAPK-mediated nuclear-cytoplasmic viral ribonucleoprotein export in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 8 hrs post-infection by inmmunofluorescence	22743086
dog MDCK cells		Function assay		Restoration of GSH level in dog MDCK cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 24 hrs post-infection by DTNB-based colometric assay	22743086
Hepa lclc7 cells		Cytotoxicity assay		Cytotoxicity against mouse Hepa lclc7 cells, IC50=39 μM	18076142
Hepa lclc7 cells		Function assay		Induction of mouse quinone reductase in mouse Hepa lclc7 cells assessed as concentration required to double enzyme activity	18076142
Hepa-1c1c7 cells		Function assay		Induction of quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double enzyme activity	12762787
human T47D cells		Function assay	96 h	Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
HUVEC		Cytotoxicity assay	48 h	Toxicity against HUVEC incubated for 48 hrs by MTT assay, IC50=41.17 μM	25590864
J774.1 cells		Function assay	24 h	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=29.3 μM	15974608
K562 cells		Cytotoxicity assay	48 h	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay, IC50=29.27 μM	25590864
KB cells		Growth inhibition assay		Compound concentration required to reduce the exponential growth of KB cells by 50%, CC50=12 μM	9767632
MCF7 cells	25-150 μM	Cytotoxicity assay	72 h	Cytotoxicity against human MCF7 cells at 25 to 150 uM after 72 hrs by MTT assay	18603336
MCF7 cells		Function assay	96 h	Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol after 96 hrs by alamar blue assay	19928832
MCF7 cells		Function assay		Estrogenic activity in luciferase transfected human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by luciferase reporter gene assay	19928832
mouse NIH3T3 cells		Function assay	8 h	Inhibition of cobalt chloride-induced HIF-1 activation expressed in mouse NIH3T3 cells after 8 hrs by luciferase reporter gene assay, IC50=4.8 μM	21112783
MT-4 cells		Growth inhibition assay		Compound concentration required to reduce the exponential growth of MT-4 cells by 50%, CC50=7.4 μM	9767632
NCI-H292 cells		Function assay		Inhibition of PKC-mediated PKD phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells		Function assay		Inhibition of PKC-mediated p38MAPK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
NCI-H292 cells		Function assay		Inhibition of PKC-mediated JNK phosphorylation in human NCI-H292 cells infected with Influenza virus A/Puerto Rico/8/34 H1N1 measured at 6 hrs post-infection by immunoblotting analysis	22743086
OE21 cells		Cytotoxicity assay	72 h	Cytotoxicity against human OE21 cells after 72 hrs by MTT assay, IC50=48 μM	21696954
PC3 cells		Cytotoxicity assay		Cytotoxicity against human PC3 cells, IC50=46.4 μM	16441066
RBL-1 cells		Function assay		In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined, IC50=35 μM	8254620
U937 cells	5 ug/ml	Function assay	24 h	Antiinflammatory activity in human U937 cells assessed as inhibition of LPS-induced CCL5 secretion at 5 ug/ml after 24 hrs by ELISA relative to control	21866899
U937 cells	5 ug/ml	Function assay		Inhibition of LPS-induced AP-1 activation in human U937 cells at 5 ug/ml after 1 hr relative to control	21866899

异甘草素 /Isoliquiritigenin {[allProObj[0].p_purity_real_show]}

Isoliquiritigenin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Isoliquiritigenin 质控信息

Isoliquiritigenin 生物活性

Isoliquiritigenin 细胞研究

Isoliquiritigenin 参考文献

Isoliquiritigenin 实验方案

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全球学术期刊中引用的产品

Isoliquiritigenin 质控信息

Isoliquiritigenin 生物活性

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Isoliquiritigenin 参考文献

Isoliquiritigenin 实验方案

Isoliquiritigenin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

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临床研究

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