There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Thiomyristoyl is an effective and specific inhibitor of SIRT2, exhibiting broad anti-cancer activity with minimal effects on non-cancerous cells. The inhibition of SIRT2 by Thiomyristoyl promotes ubiquitination and degradation of c-Myc, indicating potential therapeutic value against certain c-Myc-driven cancers. Thiomyristoyl inhibits SIRT2 with an IC50 of 28 nM, while it inhibits SIRT1 with an IC50 of 98 μM, and does not inhibit SIRT3 even at 200 μM. Thiomyristoyl has been shown to inhibit three human breast cancer cell lines: MCF-7, MDA-MB-468, and MDA-MB-231[1].
Thiomyristoyl/硫肉豆蔻酰 动物研究
Animal study
In a mouse model of breast cancer, Thiomyristoyl significantly suppresses tumor growth without apparent toxicity to the mice, as no significant weight loss was observed in mice treated with TM. Compared to control-treated mice, Thiomyristoyl-treated mice showed a moderate but statistically significant increase in acetylated-α-tubulin levels in tumors, confirming the in vivo inhibition of SIRT2 by Thiomyristoyl[1].
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