There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | SIRT1 ↓ ↑ | SIRT2 ↓ ↑ | SIRT3 ↓ ↑ | SIRT5 ↓ ↑ | SIRT6 ↓ ↑ | SIRT7 ↓ ↑ | Sirtuin ↓ ↑ | 其他靶点 | 纯度 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Selisistat |
++++
SIRT1, IC50: 38 nM |
99%+ | |||||||||||||||||
Resveratrol | ✔ | 98% | |||||||||||||||||
Inauhzin | ✔ | p53 | 99%+ | ||||||||||||||||
Suramin sodium salt |
+++
SirT1, IC50: 297 nM |
++
SirT5, IC50: 22 μM |
99%+ | ||||||||||||||||
Salermide | ✔ | 99% | |||||||||||||||||
Quercetin Dihydrate | ✔ | 95% | |||||||||||||||||
Sirtinol |
+
SIRT1, IC50: 131 μM |
++
SIRT2, IC50: 38 μM |
98%+ | ||||||||||||||||
AGK2 |
+++
SIRT2, IC50: 3.5 μM |
99%+ | |||||||||||||||||
Tenovin-3 | ✔ | p53 | 99%+ | ||||||||||||||||
3-TYP |
++++
SIRT1, IC50: 88 nM |
++++
SIRT2, IC50: 92 nM |
++++
SIRT3, IC50: 16 nM |
95% | |||||||||||||||
Tenovin-6 |
++
SIRT1, IC50: 21 μM |
++
SIRT2, IC50: 10 μM |
+
SIRT3, IC50: 67 μM |
p53 | 99%+ | ||||||||||||||
SirReal2 |
+++
SIRT2, IC50: 140 nM |
99%+ | |||||||||||||||||
Thiomyristoyl |
++++
SIRT2, IC50: 28 nM |
99%+ | |||||||||||||||||
Et-29 | ✔ | 98% | |||||||||||||||||
OSS_128167 |
+
SIRT1, IC50: 1578 μM |
+
SIRT2, IC50: 751 μM |
+
SIRT6, IC50: 89 μM |
98% | |||||||||||||||
SIRT7 inhibitor 97491 |
+++
SIRT7, IC50: 325 nM |
97% | |||||||||||||||||
Nicotinamide | ✔ | 99+% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Thiomyristoyl is an effective and specific inhibitor of SIRT2, exhibiting broad anti-cancer activity with minimal effects on non-cancerous cells. The inhibition of SIRT2 by Thiomyristoyl promotes ubiquitination and degradation of c-Myc, indicating potential therapeutic value against certain c-Myc-driven cancers. Thiomyristoyl inhibits SIRT2 with an IC50 of 28 nM, while it inhibits SIRT1 with an IC50 of 98 μM, and does not inhibit SIRT3 even at 200 μM. Thiomyristoyl has been shown to inhibit three human breast cancer cell lines: MCF-7, MDA-MB-468, and MDA-MB-231[1]. |
Animal study | In a mouse model of breast cancer, Thiomyristoyl significantly suppresses tumor growth without apparent toxicity to the mice, as no significant weight loss was observed in mice treated with TM. Compared to control-treated mice, Thiomyristoyl-treated mice showed a moderate but statistically significant increase in acetylated-α-tubulin levels in tumors, confirming the in vivo inhibition of SIRT2 by Thiomyristoyl[1]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.72mL 0.34mL 0.17mL |
8.59mL 1.72mL 0.86mL |
17.19mL 3.44mL 1.72mL |
CAS号 | 1429749-41-6 |
分子式 | C34H51N3O3S |
分子量 | 581.852 |
别名 | TM |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Sealed in dry,2-8°C |
溶解方案 |
DMSO: 30 mg/mL(51.56 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO 无水乙醇: 15 mg/mL(25.78 mM),配合低频超声助溶,注意:无水乙醇开封后,易挥发,也会吸收空气中的水分,导致溶解能力下降,请避免使用开封较久的乙醇 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
|
动物实验配方 |