OSS_128167 | OSS-128167 | SIRT6 Inhibitor | AmBeed-信号通路专用抑制剂

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5-(3-(呋喃-2-甲酰胺基)苯甲酰氨基)-2-羟基苯甲酸 /OSS_128167 99%+

货号：A724428 同义名： OSS-128167;SIRT6-IN-1

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects.

OSS_128167 化学结构
CAS号：887686-02-4

OSS_128167 3D分子结构
CAS号：887686-02-4

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OSS_128167 纯度/质量文件产品仅供科研

货号：A724428 标准纯度： 99%+ 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

Sirtuin 亚型比较

产品名称	SIRT1 ↓ ↑	SIRT2 ↓ ↑	SIRT3 ↓ ↑	SIRT5 ↓ ↑	SIRT6 ↓ ↑	SIRT7 ↓ ↑	Sirtuin ↓ ↑	其他靶点	纯度
Selisistat	++++ SIRT1, IC50: 38 nM								99%+
Resveratrol	✔								98%
Inauhzin	✔							p53	99%+
Suramin sodium salt	+++ SirT1, IC50: 297 nM			++ SirT5, IC50: 22 μM					99%+
Salermide	✔								99%+
Quercetin Dihydrate	✔								98%+
Sirtinol	+ SIRT1, IC50: 131 μM	++ SIRT2, IC50: 38 μM							98%+
AGK2		+++ SIRT2, IC50: 3.5 μM							99%+
Tenovin-3		✔						p53	99%+
3-TYP	++++ SIRT1, IC50: 88 nM	++++ SIRT2, IC50: 92 nM	++++ SIRT3, IC50: 16 nM						99%+
Tenovin-6	++ SIRT1, IC50: 21 μM	++ SIRT2, IC50: 10 μM	+ SIRT3, IC50: 67 μM					p53	99%+
SirReal2		+++ SIRT2, IC50: 140 nM							99%+
Thiomyristoyl		++++ SIRT2, IC50: 28 nM							99%+
Et-29				✔					98%
OSS_128167	+ SIRT1, IC50: 1578 μM	+ SIRT2, IC50: 751 μM			+ SIRT6, IC50: 89 μM				99%+
SIRT7 inhibitor 97491						+++ SIRT7, IC50: 325 nM			97%
Nicotinamide							✔		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

OSS_128167 生物活性

靶点

SIRT1

SIRT1, IC50:1578 μM
SIRT2

SIRT2, IC50:751 μM
SIRT6

SIRT6, IC50:89 μM

描述

Sirtuin 6 (SIRT6) is a NAD⁺-dependent deacetylase that regulates DNA repair, telomere maintenance, glucose and lipid metabolism, inflammation, and cancer. OSS_128167 is a selective SIRT6 inhibitor with IC50 values of 89 ± 5μM, 1578 ± 47μM, and 751 ± 23μM for SIRT6, SIRT1, and SIRT2, respectively^[4]. OSS_128167 inhibited hepatitis B virus (HBV) transcription and replication in vitro at a concentration of 100μM. In HepG2.2.15 and HBV-infected HepG2-sodium taurocholate cotransporting polypeptide cells, the promotion of SIRT6 overexpression on HBV transcription and replication was blocked by OSS_128167 at 100μM. Administration of HBV transgenic mice with 50mg/kg OSS_128167 resulted in a significant reduction of HBV DNA in serum, as well as serum hepatitis B surface antigen and hepatitis B envelope antigen^[5].

OSS_128167 参考文献

[1]Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.

[2]Jiang H, et al. SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α. Front Pharmacol. 2019 Oct 25;10:1270.

[3]Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50.

[4]Parenti MD, Grozio A, Bauer I, Galeno L, Damonte P, Millo E, Sociali G, Franceschi C, Ballestrero A, Bruzzone S, Del Rio A, Nencioni A. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804.

[5]Jiang H, Cheng ST, Ren JH, Ren F, Yu HB, Wang Q, Huang AL, Chen J. SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α. Front Pharmacol. 2019 Oct 25;10:1270.

OSS_128167 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.73mL

0.55mL

0.27mL

13.65mL

2.73mL

1.36mL

27.30mL

5.46mL

2.73mL

OSS_128167 技术信息

CAS号	887686-02-4
分子式	C₁₉H₁₄N₂O₆
分子量	366.324

别名	OSS-128167;SIRT6-IN-1
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 100 mg/mL(272.98 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

2% DMSO+40% PEG 300+2% Tween 80+water 12 mg/mL

5-(3-(呋喃-2-甲酰胺基)苯甲酰氨基)-2-羟基苯甲酸 /OSS_128167 99%+

OSS_128167 纯度/质量文件产品仅供科研

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SIRT1	SIRT1, IC50:1578 μM
SIRT2	SIRT2, IC50:751 μM
SIRT6	SIRT6, IC50:89 μM

5-(3-(呋喃-2-甲酰胺基)苯甲酰氨基)-2-羟基苯甲酸 /OSS_128167 99%+

OSS_128167 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

OSS_128167 质控信息

OSS_128167 生物活性

OSS_128167 参考文献

OSS_128167 实验方案

OSS_128167 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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OSS_128167 纯度/质量文件产品仅供科研