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Isoliquiritigenin

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Chemical Structure| 961-29-5 同义名 : GU17;ISL;GU 17, Isoliquiritigenin;4,2',4'-Trihydroxychalcone;ILQ;SJ000286237;Isoliquiritigen
CAS号 : 961-29-5
货号 : A289179
分子式 : C15H12O4
纯度 : 98+%
分子量 : 256.253
MDL号 : MFCD00075907
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(409.75 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(390.24 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco[3]. Isoliquiritigenin inhibited rat lens aldose reductase with an IC50 of 3.2 x 10(-7) M, using DL-glyceraldehyde as a substrate. It inhibited sorbitol accumulation in human red blood cells, with an IC50 of 2.0 x 10(-6) M[4]. Isoliquiritigenin treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. Moreover, Isoliquiritigenin reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes[3]. Isoliquiritigenin also showed the most potent inhibition of mouse rectal contraction induced by CCh(carbamylcholine) with an IC50 value of 1.70+/-0.07 microM[5].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
CHO cells Cytotoxicity assay Cytotoxicity against CHO cells by MTT assay, IC50=45.9 μM 19572738
colon 26-L5 cells Cytotoxicity assay 72 h Cytotoxicity against mouse colon 26-L5 cells after 72 hrs by MTT assay, IC50=21.8 μM 18440233
dog MDCK cells 20 ug/mL Function assay 1 h Antiviral activity against Influenza virus A/Puerto Rico/8/34 H1N1 infected in dog MDCK cells assessed as inhibition of viral replication at 20 ug/mL incubated at 1 hr post-infection measured after 24 hrs by hemagglutininating unit assay relative to control 22743086
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.90mL

0.78mL

0.39mL

19.51mL

3.90mL

1.95mL

39.02mL

7.80mL

3.90mL
参考文献

[1]Nerya O, Vaya J, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7.

[2]Aida K, Tawata M, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.

[3]Zhang X, Zhu P, Zhang X, Ma Y, Li W, Chen JM, Guo HM, Bucala R, Zhuang J, Li J. Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. doi: 10.1155/2013/390890. Epub 2013 Sep 16. PMID: 24163504; PMCID: PMC3791876.

[4]Aida K, Tawata M, Shindo H, Onaya T, Sasaki H, Yamaguchi T, Chin M, Mitsuhashi H. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8. doi: 10.1055/s-2006-960950. PMID: 2118267.

[5]Sato Y, He JX, Nagai H, Tani T, Akao T. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. doi: 10.1248/bpb.30.145. PMID: 17202675.