Sirtinol is an inhibitor of sirtuin (SIRT), with IC50 values of 48 μM, 57.7 μM, and 131 μM for ySir2, hSIRT2, and hSIRT2, respectively[1][2][3][4].
体内研究
Sirtinol exhibits anti-inflammatory properties by directly inhibiting HNE activity and mitigates HNE-induced and LPS-mediated tissue or organ injury[3].
体外研究
Sirtinol diminishes the growth of MCF-7 cells in a manner dependent on concentration and time. The IC50 values for sirtinol are 48.6 μM and 43.5 μM following 24 and 48 hours of treatment, respectively. Moreover, Sirtinol notably reduces SIRT1 expression and elevates acetylated p53 levels[1].
Sirtinol suppresses proliferation and promotes apoptosis in nonsmall cell lung cancer (NSCLC) H1299 cells, leading to a significant increase in the level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1[2].
Sirtinol 细胞研究
细胞系
浓度
检测类型
检测时间
活动说明
数据源
human MCF7 cells
30 μM
Proliferation assay
24-72 h
Antiproliferative activity against human MCF7 cells at 30 uM after 24 to 72 hrs
24340169
human MCF7 cells
50 μM
Function assay
24 h
Inhibition of SIRT1 in human MCF7 cells assessed as increase in acetylation of p53 at lys 382 at 50 uM after 24 hrs by Western blot analysis
24340169
human U937 cells
50 μM
Apoptosis assay
45 h
Induction of apoptosis in human U937 cells at 50 uM after 45 hrs by flow cytometry
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