马来酸伊索拉定 /Irsogladine maleate
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货号：A299639
同义名：
MN1695;Dicloguamine maleate
Irsogladine maleate 是一种 PDE4 抑制剂，并可与毒蕈碱乙酰胆碱受体结合，常用于消化系统相关疾病的研究。
Irsogladine maleate 化学结构
Irsogladine maleate 3D分子结构
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Irsogladine maleate 纯度/质量文件 产品仅供科研
货号：A299639
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Irsogladine maleate 质控信息
Irsogladine maleate 生物活性
描述
Irsogladine Maleate is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. IM (Irsogladine Maleate) treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3%, in tPA-deficient mice by 42.6 and 46%, and in uPA-deficient mice by 27.2 and 46%, respectively[3] [4] [5] [6] [7]
Irsogladine maleate 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03509831
Gastritis
Phase 1
Active, not recruiting
April 2018
Korea, Republic of
... 展开 >>
Kukje Pharm
Seongnam-si, Korea, Republic of 收起 <<
NCT02581696
Peptic Ulcer
Phase 1
Completed
-
Korea, Republic of
... 展开 >>
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, Korea, Republic of 收起 <<
NCT02759224
Gastric Ulcer
Phase 1
Completed
-
Korea, Republic of
... 展开 >>
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, Korea, Republic of 收起 <<
Irsogladine maleate 参考文献
[1] Nozaki S, Maeda M, et al. Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res Treat. 2004 Feb;83(3):195-9.
[2] Kyoi T, Kitazawa S, et al. Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. J Pharmacol Sci. 2004 Jul;95(3):321-8.
[3] Ren CJ, Ueda F, Roses DF, Harris MN, Mignatti P, Rifkin DB, Shapiro RL. Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res. 1998 Jul 1;77(2):126-31
[4] Kawasaki Y, Tsuchida A, Sasaki T, Yamasaki S, Kuwada Y, Murakami M, Chayama K. Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas. 2002 Nov;25(4):373-7
[5] Nomura M, Kamata M, Kojima H, Hayashi K, Sawada S. Irsogladine maleate reduces the incidence of fluorouracil-based chemotherapy-induced oral mucositis. Ann Oncol. 2013 Apr;24(4):1062-6
[6] Fujita T, Kishimoto A, Shiba H, Hayashida K, Kajiya M, Uchida Y, Matsuda S, Takeda K, Ouhara K, Kawaguchi H, Abiko Y, Kurihara H. Irsogladine maleate regulates neutrophil migration and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. Biochem Pharmacol. 2010 May 15;79(10):1496-505
[7] Shim KN, Kim JI, Kim N, Kim SG, Jo YJ, Hong SJ, Shin JE, Kim GH, Park KS, Choi SC, Kwon JG, Kim JH, Kim HJ, Kim JW. The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis. Korean J Intern Med. 2019 Sep;34(5):1008-1021
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Irsogladine maleate 实验方案
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总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.69mL
0.54mL
0.27mL
13.43mL
2.69mL
1.34mL
26.87mL
5.37mL
2.69mL
Irsogladine maleate 技术信息
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