H4R antagonist 3
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货号：A1217678
H4R antagonist 3是一种组胺-4 受体 (H4R) 拮抗剂，EC50 < 10 mM。该化合物可用于炎症、自身免疫性疾病、过敏反应以及眼部疾病的预防性研究，尤其适合于研究组胺介导的疾病机制。
H4R antagonist 3 化学结构
CAS号：1003091-20-0
H4R antagonist 3 3D分子结构
CAS号：1003091-20-0
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H4R antagonist 3 纯度/质量文件 产品仅供科研
货号：A1217678
标准纯度：
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H4R antagonist 3 质控信息
| Hydroxyzine 2HCl |
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99+% |
| Cyclizine |
✔
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97% |
| Loratadine |
+
|
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|
98% |
| Desloratadine |
++
Histamine H1 receptor, IC50: 51 nM
|
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98% |
| Doxylamine succinate |
✔
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99% |
| Ebastine |
✔
|
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|
|
98% |
| Tripelennamine HCl |
+
|
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|
|
98% |
| Meclizine dihydrochloride |
✔
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|
98% |
| Chlorpheniramine maleate |
+++
Histamine H1 receptor, IC50: 12 nM
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|
99% |
| Diphenhydramine HCl |
✔
|
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|
99% |
| Alcaftadine |
++++
|
++
|
|
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|
99%+ |
| Fexofenadine HCl |
++
Histamine H1 receptor, IC50: 246 nM
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|
99%+ |
| Bilastine |
+++
H1 receptor, Ki: 44.15 nM
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|
98% |
| Pemirolast potassium |
✔
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|
98% |
| Bepotastine besilate |
+
Histamine H1 receptor, pIC50: 5.7
|
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|
98% |
| Mizolastine |
+++
Histamine H1 receptor, IC50: 47 nM
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|
98% |
| Brompheniramine maleate |
✔
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|
98% |
| Carbinoxamine maleate salt |
✔
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|
99+% |
| Clemastine fumarate |
++++
Histamine H1 receptor, IC50: 3 nM
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|
98% |
| Ketotifen fumarate salt |
✔
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95% |
| Rupatadine Fumarate |
++
Histamine H1 receptor, Ki: 102 nM
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PAFR
|
98% |
| Famotidine |
|
✔
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|
97% |
| Roxatidine Acetate HCl |
|
+
Histamine H2 receptor, IC50: 3.2 μM
|
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|
98% |
| Lafutidine |
|
✔
|
|
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|
99% |
| Cimetidine |
|
✔
|
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98% |
| Nizatidine |
|
++++
Histamine H2 receptor, IC50: 0.9 nM
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AChE
|
98% |
| Ranitidine |
|
✔
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|
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|
|
98% |
| Betahistine |
|
|
+
Histamine H3 receptor, IC50: 1.9 μM
|
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|
98% |
| Ciproxifan maleate |
|
|
+++
Histamine H3 receptor, IC50: 9.2 nM
|
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|
99%+ |
| S 38093 |
|
|
++
human H3 receptor, Ki: 1.2 μM
rat H3 receptor, Ki: 1.44 μM
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98% |
| JNJ-7777120 |
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|
++++
Histamine H4 receptor, Ki: 4.5 nM
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|
98% |
| Azelastine HCl |
|
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✔
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|
98% |
| Epinastine HCl |
|
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✔
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|
98% |
| Levodropropizine |
|
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✔
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|
97% |
| Cyproheptadine hydrochloride |
|
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✔
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|
98% |
| Hesperetin |
|
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✔
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|
97% |
| Olopatadine HCl |
|
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✔
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|
98% |
| Mianserin hydrochloride |
|
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✔
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|
99+% |
| Buclizine 2HCl |
|
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✔
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|
97% |
| Latrepirdine 2HCl |
|
|
|
|
✔
|
GluR
|
98% |
| Cetirizine 2HCl |
|
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|
✔
|
|
98% |
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
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H4R antagonist 3 实验方案
| 计算器 |
|
| 存储液制备 |
 |
1mg |
5mg |
10mg |
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1 mM
5 mM
10 mM
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2.68mL
0.54mL
0.27mL
|
13.41mL
2.68mL
1.34mL
|
26.82mL
5.36mL
2.68mL
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H4R antagonist 3 技术信息
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