Dihydroevocarpine | mTORC1/2 Inhibitor | AmBeed-信号通路专用抑制剂

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Dihydroevocarpine {[allProObj[0].p_purity_real_show]}

货号：A791952

Dihydroevocarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa, is a moderate modulator of p-glycoprotein (p-gp) activity. Dihydroevocarpine also shows more potent inhibitory effects against MAO-B compared to MAO-A and potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 mg/mL.

Dihydroevocarpine 化学结构
CAS号：15266-35-0

Dihydroevocarpine 3D分子结构
CAS号：15266-35-0

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Dihydroevocarpine 纯度/质量文件产品仅供科研

货号：A791952 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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MAO 亚型比较
mTOR 亚型比较

产品名称	MAO ↓ ↑	MAO-A ↓ ↑	MAO-B ↓ ↑	纯度
Sennoside A	++ MAO, IC50: 17 μM			98%+
Glycyrrhizic acid	++++ MAO, IC50: 0.16 μM			80% HPLC
Rasagiline		++++ MAO-A, IC50: 412 nM	++++ MAO-B, IC50: 4.43 nM	99+%
Isatin	++ MAO, IC50: 15 μM	+ MAO-A, IC50: 58 μM	++ MAO-B, IC50: 14 μM	98%
Paeonol		+ MAO-A, IC50: 54.6 μM	+ MAO-B, IC50: 42.5 μM	98%
Tranylcypromine hydrochloride		+++ MAO-A, IC50: 11.5 μM	+++ MAO-B, IC50: 7 μM	97%
Moclobemide		+++ MAO-A (5-HT), IC50: 6.1 μM		99%+
Pargyline HCl		++ MAO-A, Ki: 13 μM	+++ MAO-B, Ki: 0.5 μM	99%+
Safinamide			++++ MAO-B, IC50: 98 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (truncated), IC50: 0.13 nM mTOR (full length), IC50: 0.8 nM				99%+
Gedatolisib	++++ mTOR, IC50: 1.6 nM				98%
GSK1059615	++ mTOR, IC50: 12 nM				98%
Vistusertib	+++ mTOR, IC50: 2.8 nM				99%+
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	99%+
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				98+%
PI-103	+ mTOR, IC50: 30 nM				99%+
WAY-600	++ mTOR, IC50: 9 nM				99%
Voxtalisib	+ mTOR, IC50: 157 nM				99%+
PF-04691502	++ mTOR, Ki: 16 nM				98+%
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	99%+
Chrysophanol	✔			EGFR	98%
Samotolisib	✔			DNA-PK	99%+
Torkinib	+++ mTOR, IC50: 8 nM			PDGFR,DNA-PK	99%+
Everolimus					99%+
WYE-354	+++ mTOR, IC50: 5 nM				98%
Tacrolimus	✔				98%
PP121	++ mTOR, IC50: 13 nM			VEGFR,PDGFR	99%+
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	99%+
Rapamycin	++++ mTOR, IC50: ~0.1 nM				98%
GDC-0349	+++ mTOR, Ki: 3.8 nM				98%
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		99%+
WYE-687	+++ mTOR, IC50: 7 nM				98+%
Apitolisib	+ mTOR, Ki app: 17 nM				98%+
WYE-132	++++ mTOR, IC50: 0.19 nM				99%+
Sapanisertib	++++ mTOR, Ki: 1.4 nM				99%+
BGT226 maleate	✔				99%+
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	98%
PI3K-IN-1	+ mTOR, IC50: 157 nM				98+%
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				99+%
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		99%+
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				99%+
Temsirolimus	+ mTOR, IC50: 1.76 μM				99%
CZ415	++ mTOR, pIC50: 8.07				99%+
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	99%+
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		99%+
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		99%+
Palomid 529		✔			99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Dihydroevocarpine 生物活性

描述

Dihydroevocarpine, a natural product isolated and purified from the fruits of Evodia rutaecarpa, is a moderate modulator of p-glycoprotein (p-gp) activity. Dihydroevocarpine also shows more potent inhibitory effects against MAO-B compared to MAO-A and potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 mg/mL.

Dihydroevocarpine 参考文献

[1]Yin YY, Yan LH, et al. [Simultaneous determination of seven constituents in Euodiae Fructus and two related species by HPLC] . Zhongguo Zhong Yao Za Zhi. 2014 Jul;39(14):2693-8. Chinese.

[2]Tang X, Huang Z, et al. Simultaneous determination of six bioactive compounds in Evodiae Fructus by high-performance liquid chromatography with diode array detection. J Chromatogr Sci. 2014 Feb;52(2):149-56.

Dihydroevocarpine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.93mL

0.59mL

0.29mL

14.64mL

2.93mL

1.46mL

29.28mL

5.86mL

2.93mL

Dihydroevocarpine 技术信息

CAS号	15266-35-0
分子式	C₂₃H₃₅NO
分子量	341.53

别名
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末

溶解度

DMSO: 16 mg/mL(46.85 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

Dihydroevocarpine {[allProObj[0].p_purity_real_show]}

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Dihydroevocarpine {[allProObj[0].p_purity_real_show]}

Dihydroevocarpine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Dihydroevocarpine 质控信息

Dihydroevocarpine 生物活性

Dihydroevocarpine 参考文献

Dihydroevocarpine 实验方案

Dihydroevocarpine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Dihydroevocarpine 纯度/质量文件产品仅供科研