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/ 5-Aminosalicylic Acid

5-氨基水杨酸 /5-Aminosalicylic Acid {[allProObj[0].p_purity_real_show]}

货号：A105320 同义名： 5-氨基-2-羟基苯甲酸 / Mesalamine;5-ASA

5-Aminosalicylic Acid is a potent inhibitor of interleukin 1 β production used to treat inflammatory bowel disease.

5-Aminosalicylic Acid 化学结构 CAS号：89-57-6
5-Aminosalicylic Acid 化学结构
CAS号：89-57-6
5-Aminosalicylic Acid 3D分子结构
CAS号：89-57-6
5-Aminosalicylic Acid 化学结构 CAS号：89-57-6
5-Aminosalicylic Acid 3D分子结构 CAS号：89-57-6
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5-Aminosalicylic Acid 纯度/质量文件 产品仅供科研

货号：A105320 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 NF-κB ↓ 其他靶点 纯度
PDTC ammonium ✔ 98%
QNZ ++++

NF-κB, IC50: 11 nM

 		99%+
Sodium 4-Aminosalicylate Dihydrate ✔ 98%
Sodium Salicylate ✔ 95%
Parthenolide ✔ p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

 		98%
Phenethyl caffeate ✔ 98%
Andrographolide ✔ 98+%
Curcumin ✔ Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

 		99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

5-Aminosalicylic Acid 生物活性

描述 F-5-Aminosalicylic acid (5-ASA) is a specific agonist for PPARγ, and only PPARγ but not PPARα or PPARδ induces p65 degradation. 5-Aminosalicylic acid induces degradation of p65 protein indicative of PPARγ's E3 ubiquitin ligase activity. 5-Aminosalicylic acid blocks NF-κB in intestinal epithelial cells (IECs) through inhibition of PAK1[3]. Pretreatment with 5-Aminosalicylic acid (5-ASA) or Nimesulide at different concentration (10-1000 μmol/L) for 12-96 h, inhibits the growth of HT-29 colon carcinoma cells in a dose and time-dependent manner. Combined 5-Aminosalicylic acid (final concentration 100 μM) and Nimesulide (final concentration 10-1000 μM) inhibits the proliferation of HT-29 colon carcinoma cells in a dose-dependent manner, being more potent than corresponding dose of Nimesulide. In A/JOlaHsd mice, 5-ASA suppressed colon carcinogenesis by decreasing the number of aberrant crypt foci (75%) and aberrant crypts (22%) induced by AOM (azoxymethane) treatment with an absence of 5-ASA response after GW9662 administration[4]. Pretreatment with 5-ASA or nimesulide at the concentration of 10-1000 micromol/L inhibited proliferation of HT-29 colon carcinoma cells in a dose-dependent manner in vitro. The inhibition rate of HT-29 colon carcinoma cell proliferation was also increased when pretreated with 5-ASA (100 micromol/L) or nimesulide (100 micromol/L) for 12-96 h, which showed an obvious time-effect relationship. 5-ASA and nimesulide may inhibit the proliferation of HT-29 colon carcinoma cells and coadministration of these agents may have additional chemopreventive potential[5].

5-Aminosalicylic Acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00746447 Colitis, Ulcerative ... 展开 >> Recurrence 收起 << Phase 3 Completed - Germany ... 展开 >> Evangelisches Krankenhaus Kalk, Medical Dept. Cologne, Germany, 51103 收起 <<
NCT01699438 Irritable Bowel Syndrome Phase 2 Completed - Sweden ... 展开 >> Sahlgrenska University Hospital Göteborg, Sweden Karolinska University Hospital Huddinge, Sweden Norrland's University Hospital Umeå, Sweden 收起 <<
NCT01257399 Ulcerative Colitis in Remissio... 展开 >>n 收起 << Phase 3 Completed - China ... 展开 >> Shanghai Hospital Shanghai, China 收起 <<

5-Aminosalicylic Acid 参考文献

[1]Khare V, Lyakhovich A, et al. Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochem Pharmacol. 2013 Jan 15;85(2):234-44.

[2]Egan LJ, Mays DC, et al. Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity. J Biol Chem. 1999 Sep 10;274(37):26448-53.

[3]Dammann K, Khare V, Lang M, Claudel T, Harpain F, Granofszky N, Evstatiev R, Williams JM, Pritchard DM, Watson A, Gasche C. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60

[4]Rousseaux C, El-Jamal N, Fumery M, Dubuquoy C, Romano O, Chatelain D, Langlois A, Bertin B, Buob D, Colombel JF, Cortot A, Desreumaux P, Dubuquoy L. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34(11):2580-6

[5]Fang HM, Mei Q, Xu JM, Ma WJ. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13(20):2872-7

5-Aminosalicylic Acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

6.53mL

1.31mL

0.65mL

32.65mL

6.53mL

3.27mL

65.30mL

13.06mL

6.53mL

5-Aminosalicylic Acid 技术信息

CAS号89-57-6
分子式C7H7NO3
分子量 153.135
别名 5-氨基-2-羟基苯甲酸 ;Mesalamine;5-ASA;MAX-002;AJG-501;Z-206;Asacol;Mesalazine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 65 mg/mL(424.46 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 5-Aminosalicylic Acid | Mesalamine;5-ASA;MAX-002;AJG-501;Z-206;Asacol;Mesalazine | 5-氨基-2-羟基苯甲酸 | Digestive System | Anti-inflammation | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | NF-κB | IKK | IL | AmBeed-信号通路专用抑制剂 | 5-Aminosalicylic Acid 纯度/质量文件 | 5-Aminosalicylic Acid 亚型比较 | 5-Aminosalicylic Acid 生物活性 | 5-Aminosalicylic Acid 临床数据 | 5-Aminosalicylic Acid 参考文献 | 5-Aminosalicylic Acid 实验方案 | 5-Aminosalicylic Acid 技术信息

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