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非诺贝特酸 /Fenofibric acid {[allProObj[0].p_purity_real_show]}

货号:A399267 同义名: FNF acid;NSC 281318

Fenofibric acid是 PPAR 的激动剂,能够调节脂质水平,并抑制 COX-2。

Fenofibric acid 化学结构 CAS号:42017-89-0
Fenofibric acid 化学结构
CAS号:42017-89-0
Fenofibric acid 3D分子结构
CAS号:42017-89-0
Fenofibric acid 化学结构 CAS号:42017-89-0
Fenofibric acid 3D分子结构 CAS号:42017-89-0
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Fenofibric acid 纯度/质量文件 产品仅供科研

货号:A399267 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 PPARα PPARβ/δ PPARγ PPARδ 其他靶点 纯度
Fenofibric acid 98%
GW6471 ++

PPARα, IC50: 0.24 μM

99%+
GSK3787 ++

PPARδ, pIC50: 6.6

++

PPARδ, pIC50: 6.6

99%+
FH535 98%+
GW9662 +++

PPARα, IC50: 32 nM

+++

PPARγ, IC50: 3.3 nM

98%
T0070907 ++++

PPARγ, IC50: 1 nM

98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Fenofibric acid 生物活性

靶点
  • PPARα

描述 Fenofibric acid serves as an activator for PPAR, exhibiting EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ, and PPARδ, respectively[1]. At concentrations ranging from 10 to 100 nM, Fenofibric acid progressively inhibits the COX-2 enzyme, achieving an IC50 of 48 nM[2]. At a concentration of 500 nM, Fenofibric acid leads to a reduction in the levels of AOX1 protein in HepG2 cells[3]. Fenofibric acid at 100 µM reduces phosphorylation of JNK1/2, c-Jun, and p38 MAPK, and protects against the build-up of reactive oxygen species, endoplasmic reticulum (ER) stress, and damage to the blood retinal barrier (BRB) triggered by a combination of high-glucose and hypoxic conditions in ARPE-19 cells. Additionally, at this concentration, Fenofibric acid stimulates the IGF-IR/Akt/ERK1/2-mediated survival signaling pathways in ARPE-19 cells under these stress conditions[4].
体内研究

Fenofibric acid, administered orally in doses of 1, 5, and 10 mg/kg, demonstrates anti-inflammatory effects in Wistar rats suffering from acute inflammation induced by carrageenan[2].

体外研究

Fenofibric acid serves as an activator for PPAR, exhibiting EC50s of 22.4 µM, 1.47 µM, and 1.06 µM for PPARα, PPARγ, and PPARδ, respectively[1].

At concentrations ranging from 10 to 100 nM, Fenofibric acid progressively inhibits the COX-2 enzyme, achieving an IC50 of 48 nM[2].

At a concentration of 500 nM, Fenofibric acid leads to a reduction in the levels of AOX1 protein in HepG2 cells[3].

Fenofibric acid at 100 µM reduces phosphorylation of JNK1/2, c-Jun, and p38 MAPK, and protects against the build-up of reactive oxygen species, endoplasmic reticulum (ER) stress, and damage to the blood retinal barrier (BRB) triggered by a combination of high-glucose and hypoxic conditions in ARPE-19 cells. Additionally, at this concentration, Fenofibric acid stimulates the IGF-IR/Akt/ERK1/2-mediated survival signaling pathways in ARPE-19 cells under these stress conditions[4].

Fenofibric acid 参考文献

[1]Dietz M, et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity, activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11.

[2]Prasad GS, et al. Anti-inflammatory activity of anti-hyperlipidemic drug, fenofibrate, and its phase-I metabolite fenofibric acid: in silico, in vitro, and in vivo studies. Inflammopharmacology. 2017 Dec 13.

[3]Neumeier M, et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun. 2006 Nov 24;350(3):731-5. Epub 2006 Sep 27.

[4]Miranda S, et al. Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. J Cell Physiol. 2012 Jun;227(6):2352-62.

Fenofibric acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.69mL

3.14mL

1.57mL

31.37mL

6.27mL

3.14mL

Fenofibric acid 技术信息

CAS号42017-89-0
分子式C17H15ClO4
分子量 318.752
别名 FNF acid;NSC 281318;Procetofenic acid;Trilipix
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解方案

DMSO: 105 mg/mL(329.41 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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