产品名 | PAK ↓ ↑ | PAK1 ↓ ↑ | PAK2 ↓ ↑ | PAK3 ↓ ↑ | PAK4 ↓ ↑ | PAK5 ↓ ↑ | PAK6 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPA-3 |
+
PAK1, IC50: 2.5 μM |
+
PAK1, IC50: 2.5 μM |
99%+ | ||||||||||||||||
FRAX486 |
+++
PAK1, IC50: 14 nM PAK4, IC50: 39 nM |
+++
PAK1, IC50: 14 nM |
++
PAK2, IC50: 33 nM |
++
PAK3, IC50: 39 nM |
+
PAK4, IC50: 575 nM |
99%+ | |||||||||||||
FRAX1036 |
++
PAK2, Ki: 72.4 nM PAK4, Ki: 23.3 nM |
++
PAK1, Ki: 23.3 nM |
++
PAK2, Ki: 72.4 nM |
+
PAK4, Ki: 2.4 μM |
99%+ | ||||||||||||||
FRAX597 |
++++
PAK2, IC50: 13 nM PAK3, IC50: 13 nM |
++++
PAK1, IC50: 8 nM |
++++
PAK2, IC50: 13 nM |
+++
PAK3, IC50: 19 nM |
98+% | ||||||||||||||
PF-3758309 |
++++
PAK6, Ki: 17.1 nM PAK3, IC50: 190 nM |
++++
PAK1, Ki: 13.7 nM |
+
PAK2, IC50: 190 nM |
++
PAK3, IC50: 99 nM |
+++
PAK4, Ki: 18.7 nM |
+++
PAK5, Ki: 18.1 nM |
+++
PAK6, Ki: 17.1 nM |
99%+ | |||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |