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/ 3-O-Methylquercetin

3-O-甲基槲皮素 /3-O-Methylquercetin {[allProObj[0].p_purity_real_show]}

货号：A860292 同义名： NSC 154016;Quercetin 3-methyl ether

3-O-Methylquercetin, a natural product isolated and purified from the herbs of Croton cascarilloides with antiviral, anti-inflammatory and bronchodilating effects, is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value. 3-O-Methylquercetin also inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
3-O-Methylquercetin 化学结构 CAS号：1486-70-0
3-O-Methylquercetin 化学结构
CAS号：1486-70-0
3-O-Methylquercetin 3D分子结构
CAS号：1486-70-0
3-O-Methylquercetin 化学结构 CAS号：1486-70-0
3-O-Methylquercetin 3D分子结构 CAS号：1486-70-0
规格 价格 会员价 库存 数量
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3-O-Methylquercetin 纯度/质量文件 产品仅供科研

货号：A860292 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 PDE ↓ PDE1 ↓ PDE10A ↓ PDE2 ↓ PDE3 ↓ PDE4 ↓ PDE5 ↓ PDE6 ↓ 其他靶点 纯度
Doxofylline ✔ 99+%
Deltarasin +++

PDEδ , Kd: 38 nM

 		99+%
7-(2,3-Dihydroxypropyl)theophylline ✔ 98%
Aminophylline +

PDE, IC50: 0.12 mM

 		98+%
Anagrelide HCl ✔ 99%+
Irsogladine ✔ AChR,mAChR 98%
PF-8380 +++

Autotaxin, IC50: 2.8 nM

 		99%+
Dipyridamole ✔ 98%
Balipodect ++++

PDE10A, IC50: 0.3 nM

 		99%+
PF-2545920 ++++

PDE10A, IC50: 0.37 nM

 		97%
Luteolin +

PDE1, Ki: 15.0 μM

 		++

PDE2, Ki: 6.4 μM

 		+

PDE3, Ki: 13.9 μM

 		+

PDE4, Ki: 11.1 μM

 		+

PDE5, Ki: 9.5 μM

 		98%
Milrinone ++

PDE2, IC50: 5.2 μM

 		++

PDE3, IC50: 2.1 μM

 		ATPase 98%
Pimobendan ++

PDE3, IC50: 0.32 μM

 		98%
Cilostazol ++

PDE3, IC50: 0.2 μM

 		98%
Fenspiride HCl +

PDE3, pIC50: 3.44

 		+

PDE4, pIC50: 4.16

 		98%
(S)-(+)-Rolipram ++

PDE4, IC50: 0.75 μM

 		98%
Apremilast +++

PDE4, IC50: 74 nM

 		98%
GSK256066 ++++

PDE4B, IC50: 3.2 pM

 		98+%
Roflumilast ++++

PDE4A1, IC50: 0.7 nM

PDE4A4, IC50: 4.3 nM

 		99%
Rolipram +++

PDE4B, IC50: 130 nM

 		99%+
Cilomilast +++

HPDE4, IC50: 120 nM

LPDE4, IC50: 100 nM

 		98+%
Avanafil ++++

PDE5, IC50: 1 nM

 		98%
Vardenafil HCl Trihydrate ++++

PDE5, IC50: 0.7 nM

 		98%
Tadalafil ++++

PDE5, IC50: 1.8 nM

 		98%
Icariin ++

PDE5, IC50: 0.432 μM

 		98%
Sildenafil ✔ +++

PDE6, IC50: 33 nM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

3-O-Methylquercetin 生物活性

描述 3-O-Methylquercetin, a natural product isolated and purified from the herbs of Croton cascarilloides with antiviral, anti-inflammatory and bronchodilating effects, is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value. 3-O-Methylquercetin also inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentrations.

3-O-Methylquercetin 参考文献

[1]Fasolo D, Bassani VL, Teixeira HF. Development of topical nanoemulsions containing quercetin and 3-O-methylquercetin. Pharmazie. 2009 Nov;64(11):726-30.

[2]Ko WC, Shih CM, et al. Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness. Planta Med. 2004 Dec;70(12):1123-7.

3-O-Methylquercetin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.16mL

0.63mL

0.32mL

15.81mL

3.16mL

1.58mL

31.62mL

6.32mL

3.16mL

3-O-Methylquercetin 技术信息

CAS号1486-70-0
分子式C16H12O7
分子量 316.262
别名 NSC 154016;Quercetin 3-methyl ether
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 50 mg/mL(158.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: 3-O-Methylquercetin | 1486-70-0 | PDE Inhibitor | Metabolic Enzyme/Protease | Phosphodiesterase (PDE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | 3-O-Methylquercetin 纯度/质量文件 | 3-O-Methylquercetin 亚型比较 | 3-O-Methylquercetin 生物活性 | 3-O-Methylquercetin 参考文献 | 3-O-Methylquercetin 实验方案 | 3-O-Methylquercetin 技术信息

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