Ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the induction of apoptosis, and the inhibition of proliferation, metastasis and angiogenesis, as well as the promotion of immunity[3]. Ginsenoside Rg3 (Rg3) is one of the key components of a frequently used herbal tonic panax ginseng for fatigue treatment. In the open field test, Rg3 significantly increased the journey distance and rearing frequency, while slowed down the rest time. Rg3 could improve exercise performance and resist fatigue possibly through elevating SIRT1 (silent information regulator of transcription 1) deacetylase activity[4]. Ginsenoside Rg3 could attenuate (lipopolysaccharide) LPS-induced ALI (Acute lung injury) by decreasing the levels of pro-inflammatory mediators and increasing the production of anti-inflammatory cytokines[5]. Moreover, ginsenoside Rg3 suppresses angiogenesis in developing endometrial lesions. The ginsenoside Rg3 inhibitory effect on the growth of the ectopic endometrium in EMs rats might occur through the blocking of the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway, thus halting angiogenesis and promoting the apoptosis of ectopic endometrial cells[6].
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