Proparacaine (PPC) Hydrochloride is a derivative of lidocaine (HY-B0185), with immunomodulatory effect and glucocorticomimetic activity. Proparacaine Hydrochloride (294.47-18.85 mM; 4-12 hours) can induce apoptosis of HCS cells. Proparacaine Hydrochloride (4.71 mM; 4-12 hours) induces G1 phase arrest, plasma membrane permeability elevation, phosphatidylserine externalization, DNA fragmentation, chromatin condensation, and apoptotic body formation of HCS cells. Proparacaine Hydrochloride (4.71 mM; 4-12 hours) downregulates and upregulates the expression of Bcl-xL and Bax, respectively, and remarkably upregulates cytoplasmic cytochrome C and apoptosis inducing factor. Proparacaine Hydrochloride (>588.93 μM; 4-28 hours) has a dose- and time-dependent cytotoxicity to HCS cells at concentrations in vitro[3]. In addition, proparacaine hydrochloride is an ester-type local anesthetic agent that is extensively used in ophthalmic operations[4]. PH (Proparacaine Hydrochloride) has a mydriatic effect of its own. It penetrates through the bare sclera and leads on to skewed dilation of the pupil[5]. 0.5% proparacaine HCl is commonly used for topical anaesthesia in ultrasound pachometry prior to refractive surgery[6].
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