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20(S)-Ginsenoside Rg3

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Chemical Structure| 14197-60-5 同义名 : 20(S)-人参皂苷 Rg3;人参皂苷 Rg3;人参皂甙 Rg3 ;S-ginsenoside Rg3;Ginsenoside Rg3;VN10040;20S-Ginsenoside Rg3;20(S)-Propanaxadiol
CAS号 : 14197-60-5
货号 : A240443
分子式 : C42H72O13
纯度 : 98%
分子量 : 785.013
MDL号 : MFCD06410950
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(133.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ginsenoside Rg3, a naturally occurring phytochemical, plays an important role in the induction of apoptosis, and the inhibition of proliferation, metastasis and angiogenesis, as well as the promotion of immunity[3]. Ginsenoside Rg3 (Rg3) is one of the key components of a frequently used herbal tonic panax ginseng for fatigue treatment. In the open field test, Rg3 significantly increased the journey distance and rearing frequency, while slowed down the rest time. Rg3 could improve exercise performance and resist fatigue possibly through elevating SIRT1 (silent information regulator of transcription 1) deacetylase activity[4]. Ginsenoside Rg3 could attenuate (lipopolysaccharide) LPS-induced ALI (Acute lung injury) by decreasing the levels of pro-inflammatory mediators and increasing the production of anti-inflammatory cytokines[5]. Moreover, ginsenoside Rg3 suppresses angiogenesis in developing endometrial lesions. The ginsenoside Rg3 inhibitory effect on the growth of the ectopic endometrium in EMs rats might occur through the blocking of the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway, thus halting angiogenesis and promoting the apoptosis of ectopic endometrial cells[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.37mL

1.27mL

0.64mL

12.74mL

2.55mL

1.27mL
参考文献

[1]Joo EJ, Chun J, et al. Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor. Chem Biol Interact. 2015 May 25;233:25-34.

[2]Rhim H, Kim H, et al., Ginseng and ginsenoside Rg3, a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons. Eur J Pharmacol, 2002. 436(3): 151-8.

[3]Sun M, Ye Y, Xiao L, Duan X, Zhang Y, Zhang H. Anticancer effects of ginsenoside Rg3 (Review). Int J Mol Med. 2017;39(3):507-518

[4]Yang QY, Lai XD, Ouyang J, Yang JD. Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats. Toxicology. 2018;409:144-151

[5]Yang J, Li S, Wang L, et al. Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway. Front Pharmacol. 2018;9:850.

[6]Cao Y, Ye Q, Zhuang M, et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. PLoS One. 2017;12(11):e0186520.