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(S)-(+)-Rolipram

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Chemical Structure| 85416-73-5 同义名 : S-(+)-Rolipram;(+)-Rolipram;(S)-Rolipram
CAS号 : 85416-73-5
货号 : A107169
分子式 : C16H21NO3
纯度 : 98%
分子量 : 275.343
MDL号 : -
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(381.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

IP 2% DMSO+2% Tween80+30% PEG300+water 7 mg/mL clear

PO 0.5% CMC-Na 47 mg/mL suspension

生物活性
靶点

  • PDE4

    PDE4, IC50:0.75 μM
描述 (S)-(+)-Rolipram, known as (+)-Rolipram, is a selective inhibitor of cyclic AMP (cAMP)-specific phosphodiesterase 4 (PDE4) with an IC50 of 1100 nM. It is effective in suppressing tumor necrosis factor-alpha (TNFα) production in human mononuclear cells[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.63mL

0.73mL

0.36mL

18.16mL

3.63mL

1.82mL

36.32mL

7.26mL

3.63mL
参考文献

[1]Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13.

[2]Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4.

[3]Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.