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Trigonelline

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Chemical Structure| 535-83-1 同义名 : 胡芦巴碱 ;Trigenolline
CAS号 : 535-83-1
货号 : A498292
分子式 : C7H7NO2
纯度 : 99%+
分子量 : 137.136
MDL号 : MFCD00054262
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 6 mg/mL(43.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PI3K
描述 Trigonelline, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L. with phytoestrogenic and antitumor effects, inhibits the adipogenesis by its influences on the expression PPARγ, which leads to subsequent down regulation of PPAR-γ mediated pathway during adipogenesis.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02999152 Bone Metastasis ... 展开 >> Malignant Hemopathy 收起 << Not Applicable Recruiting December 31, 2019 France ... 展开 >> Institut de Cancérologie Lucien Neuwirth Recruiting Saint-Priest en Jarez, France, 42270 Principal Investigator: Nicolas Magné, PhD          Sub-Investigator: Guy De Laroche, MD          Sub-Investigator: Grégoire Pigne, MD          Sub-Investigator: Denis Guyotat, PhD          Sub-Investigator: Jérôme Cornillon, MD          Institut Gustave Roussy Not yet recruiting Villejuif, France, 94800 Contact: Valentine Martin, MD          Principal Investigator: Valentine Martin, MD          Sub-Investigator: Angela Boros, MD 收起 <<
NCT03166540 Diet Modification ... 展开 >> Cardiovascular Risk Factor Nutritional and Metabolic Diseases 收起 << Not Applicable Completed - Italy ... 展开 >> Department of Food and Drug, University of Parma Parma, Italy, 43125 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.29mL

1.46mL

0.73mL

36.46mL

7.29mL

3.65mL

72.92mL

14.58mL

7.29mL
参考文献

[1]Jeong YI, Kim DH, et al. Antitumor activity of trigonelline-incorporated chitosan nanoparticles. J Nanosci Nanotechnol. 2014 Aug;14(8):5633-7.

[2]Folwarczna J, Zych M, et al. Unfavorable effect of trigonelline, an alkaloid present in coffee and fenugreek, on bone mechanical properties in estrogen-deficient rats. Mol Nutr Food Res. 2014 Jul;58(7):1457-64.