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Thiomyristoyl

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Chemical Structure| 1429749-41-6 同义名 : TM
CAS号 : 1429749-41-6
货号 : A202420
分子式 : C34H51N3O3S
纯度 : 99%+
分子量 : 581.852
MDL号 : MFCD30738003
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(51.56 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 15 mg/mL(25.78 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • SIRT2

    SIRT2, IC50:28 nM
描述 Thiomyristoyl is an effective and specific inhibitor of SIRT2, exhibiting broad anti-cancer activity with minimal effects on non-cancerous cells. The inhibition of SIRT2 by Thiomyristoyl promotes ubiquitination and degradation of c-Myc, indicating potential therapeutic value against certain c-Myc-driven cancers. Thiomyristoyl inhibits SIRT2 with an IC50 of 28 nM, while it inhibits SIRT1 with an IC50 of 98 μM, and does not inhibit SIRT3 even at 200 μM. Thiomyristoyl has been shown to inhibit three human breast cancer cell lines: MCF-7, MDA-MB-468, and MDA-MB-231[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.59mL

1.72mL

0.86mL

17.19mL

3.44mL

1.72mL
参考文献

[1]Jing H, et al. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell. 2016 Mar 14;29(3):297-310.