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/ Oxidopamine hydrobromide

6-羟基多巴胺氢溴酸盐 /Oxidopamine hydrobromide {[allProObj[0].p_purity_real_show]}

货号：A818244 同义名： 6-Hydroxydopamine hydrobromide;6-OHDA hydrobromide

Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons.

Oxidopamine hydrobromide 化学结构 CAS号：636-00-0
Oxidopamine hydrobromide 化学结构
CAS号：636-00-0
Oxidopamine hydrobromide 3D分子结构
CAS号：636-00-0
Oxidopamine hydrobromide 化学结构 CAS号：636-00-0
Oxidopamine hydrobromide 3D分子结构 CAS号：636-00-0
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Oxidopamine hydrobromide 纯度/质量文件 产品仅供科研

货号：A818244 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 D1 receptor ↓ D2 receptor ↓ D3 receptor ↓ D4 receptor ↓ D5 receptor ↓ DAT ↓ Dopamine receptor ↓ 其他靶点 纯度
Penfluridol +

Dopamine receptor, Ki: 1.6 μM

 		98%
Ansofaxine HCl ++

Dopamine receptor, IC50: 491 nM

 		98%
Tetrahydroberberine,THB +

D2 receptor, pKi: 6.08

 		98+%
Prochlorperazine Maleate ✔ 95%
Olanzapine ✔ 99+%
Trifluoperazine ++++

Dopamine D2 receptor, IC50: 1.1 nM

 		98%
Ropinirole hydrochloride ++

D2 receptor, Ki: 29 nM

 		99%
Lurasidone ++++

D2 receptor, Ki: 1 nM

 		98%
Levosulpiride ✔ 99+%
Pridopidine ✔ 95%
Metoclopramide ✔ ✔ 99+%
Molindone HCl ✔ 98%
Sulpiride ✔ 99+%
Perospirone ++++

D2 receptor, Ki: 1.4 nM

 		99%
Perospirone HCl ++++

D2 receptor, Ki: 1.4 nM

 		98+%
Phenothiazine ✔ 98%
Pimozide +

Dopamine D1 receptor, Ki: 6600 nM

 		+++

Dopamine D2 receptor, Ki: 3.0 nM

 		++++

Dopamine D3 receptor, Ki: 0.83 nM

 		98%
Rotundine ++

D1 receptor, IC50: 166 nM

 		+

D2 receptor, IC50: 1.47 μM

 		+

D3 receptor, IC50: 3.25 μM

 		98%
Domperidone ✔ 99+%
ONC206 ✔ 97%
Pimethixene maleate ++

Dopamine D1 Receptor, pKi: 6.37

 		+++

Dopamine D2 Receptor, pKi: 8.19

 		++

Dopamine D4.4 Receptor, pKi: 7.54

 		97%
Loxapine succinate ++

D1 receptor (human), Ki: 26 nM

D2 receptor (Human), Ki: 62 nM

 		++

D2 receptor (bovine), Ki: 26 nM

D2 receptor (human), Ki: 24 nM

 		+++

D4 receptor (human), Ki: 7.5 nM

 		99%
Chlorprothixene +++

D1 receptor, Ki: 18 nM

 		+++

D2 receptor, Ki: 2.96 nM

 		+++

D3 receptor, Ki: 4.56 nM

 		+++

D5 receptor, Ki: 9 nM

 		98%
SCH-23390 HCl ++++

D1 dopamine receptor, Ki: 0.2 nM

 		++++

D5 dopamine receptor, Ki: 0.3 nM

 		98%
MPP+ iodide ✔ 97%
σ1 Receptor antagonist-1 +

DAT, pKi: 5.8

 		97%
Benztropine mesylate ++

DAT, IC50: 118 nM

 		98%
Azaperone ✔ 98%
Ziprasidone HCl ✔ 98+%
Paliperidone ✔ 98%
Alizapride HCl ✔ 99+%
Amisulpride ✔ 98%
Quetiapine hemifumarate ✔ Adrenergic Receptor 98%
Clozapine N-oxide ✔ 99%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Oxidopamine hydrobromide 生物活性

描述 Oxidopamine hydrobromide (6-OHDA hydrobromide), an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons. 6-OHDA-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation[3]. Moreover, the reduction in proteasomal activity by 6-OHDA was attenuated in SH-SY5Y cells pretreated with 1 μM CA(carnosic acid) [4]. Buspirone improves the anti-cataleptic effect of L-DOPA in a 6-OHDA-induced animal model of PD through the activation of 5-HT(1A) receptors[5].

Oxidopamine hydrobromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01108029 Parkinson's Disease ... 展开 >> Gait Disorders, Neurologic 收起 << Phase 4 Completed - France ... 展开 >> Devos Lille, France, 59037 收起 <<

Oxidopamine hydrobromide 参考文献

[1]Fujita H, Ogino T, et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.

[2]Soto-Otero R, Mendez-Alvarez E, et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.

[3]Fujita H, Ogino T, Kobuchi H, Fujiwara T, Yano H, Akiyama J, Utsumi K, Sasaki J. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23

[4]Lin CY, Tsai CW, Tsai CW. Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway. Neuropharmacology. 2016 Nov;110(Pt A):109-117

[5]Mahmoudi J, Nayebi AM, Samini M, Reyhani-Rad S, Babapour V. Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats. Pharmacol Rep. 2011;63(4):908-14

Oxidopamine hydrobromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.00mL

0.80mL

0.40mL

19.99mL

4.00mL

2.00mL

39.99mL

8.00mL

4.00mL

Oxidopamine hydrobromide 技术信息

CAS号636-00-0
分子式C8H12BrNO3
分子量 250.09
别名 6-Hydroxydopamine hydrobromide;6-OHDA hydrobromide;2,4,5-Trihydroxyphenethylamine;Oxidopamine;6-hydroxy Dopamine;6-OHDA (hydrobromide);6-OHDA
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 50 mg/mL(199.93 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(79.97 mM)，配合低频超声助溶
动物实验配方

Tags: Oxidopamine hydrobromide | 6-Hydroxydopamine hydrobromide;6-OHDA hydrobromide;2,4,5-Trihydroxyphenethylamine;Oxidopamine;6-hydroxy Dopamine;6-OHDA (hydrobromide);6-OHDA | Dopamine Receptor | DAT | AmBeed-信号通路专用抑制剂 | Oxidopamine hydrobromide 纯度/质量文件 | Oxidopamine hydrobromide 亚型比较 | Oxidopamine hydrobromide 生物活性 | Oxidopamine hydrobromide 临床数据 | Oxidopamine hydrobromide 参考文献 | Oxidopamine hydrobromide 实验方案 | Oxidopamine hydrobromide 技术信息

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