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Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons.
MPTP hydrochloride 是可透过血脑屏障的多巴胺 (dopamine) 神经毒素,用于诱导帕金森综合症模型。MPTP hydrochloride 是 MPP+ 的前体,可以诱导细胞凋亡 (apoptosis)。
Reserpine is a naturally occuring brain-penetrant and irreversible VMAT (vesicular monoamine transporter 1 and 2) antagonist.
Haloperidol 是一种典型的抗精神病药,对 D2 多巴胺受体具有高亲和力。Haloperidol 具有抗精神病作用,主要用于精神分裂症和其他精神障碍的治疗。
Rotenone is a proven complex I inhibitor with IC50 value of 1.7 - 2.2 μM.
Oxidopamine HCl is a neurotoxic synthetic organic compound, selectively destroys dopaminergic and noradrenergic neurons in the brain.
Lactacystin is a potent and selective proteasome inhibitor with an IC50 of 4.8 μM for 20S proteasome found in Streptomyces. Lactacystin also inhibits the lysosomal enzyme cathepsin A.
Reserpine HCl is a naturally occuring brain-penetrant and irreversible VMAT (vesicular monoamine transporter 1 and 2) antagonist.
Tags: 帕金森综合症模型 | Parkinsons Disease Model | 神经系统疾病模型 | Nervous System Disease Models | 帕金森综合症模型 相关产品
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