Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human.

DVR-01是一种HBV（乙型肝炎病毒）抑制剂，在AML12HBV10和HepDES19细胞中的EC₅₀值分别为1.7和1.6 μM，具有抑制HBV突变体的活性，适用于HBV感染及相关疾病的研究。

Chamaechromone is a natural product isolated and purified from the roots of Stellera chamaejasme with anti-HBV and insecticidal activity.

HBV-IN-37是一种用于抑制乙型肝炎病毒 (HBV) 复制的抑制剂，EC₅₀ 值为 10 μM，适用于抗病毒治疗研究。

Vebicorvir (ABI-H0731) 是一种乙型肝炎病毒 (HBV) 核心蛋白抑制剂。Vebicorvir (ABI-H0731) 在两种感染模型中共价抑制 cccDNA，EC50 值范围为 1.84 至 7.3 μM。

Besifovir是一种口服活性的抗HBV药物，具有显著的抗病毒活性，用于乙型肝炎的治疗。

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

Entecavir is a guanosine analogue that inhibits reverse transcription, DNA replication and transcription in the viral replication process, and is a potent, orally-active and selective inhibitor of HBV with an EC50 of 3.75 nM in HepG2 cell.

NVR3-778 is a first-in-class capsid assembly modulators currently in phase II clinical trial for the treatment of HBV infection. It exhibited anti-HBV activity with IC50 value of 0.26 µM.

Isoscopoletin is a natural product isolated and purified from the herbs of Paederia scandens (Lour.) Merr.

AB-423 is Arbutus' first-generation capsid inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies.

Oxymatrine从苦参中提取的生物碱，具有抗炎、抗纤维化和抗肿瘤特性，对iNOS表达和TGF-β/Smad通路具有抑制作用。此外，氧化苦参碱抑制犬微小病毒（MVC）复制，减少病毒基因表达，并减轻病毒感染引起的凋亡。

Bicyclol (SY 801) 是一种具有抗 HBV 和抗 HCV 性质的口服活性化合物。

Entecavir, an analogue of guanosine, is reverse transcription inhibitor of HBV with EC50 of 3.75 nM in HepG2 cell.

Tenofovir disoproxil fumarate can block reverse transcriptase which has antiviral activity against HBV and HIV-1.

Osalmid can target ribonucleotide reductase small subunit M2 (RRM2) with IC50 of 8.23 μM. It is used for cholecystitis and bile duct inflammation.

One isomer impurity of Tenofovir, which is an acyclic phosphonate nucleotide derivative, could be used to treat HIV and chronic Hepatitis B (HBV) as a reverse transcriptase inhibitor.

Telbivudine selectively inhibits hepatitis B virus (HBV) reverse transcriptase and is used in the treatment of hepatitis B infection.

Tenofovir is a nucleotide analogue reverse transcriptase inhibitors (NRTIs) which reduces the viral cytopathic effect of HIV-1 (IIIB), HIV-2(ROD) with EC50 of 1.15 μg/ml and 1.12 μg/ml.

Tenofovir dsoproxil acts as an anti-HIV agent and a reverse transcriptase inhibitor that is used to prevent HIV/AIDS and chronic hepatitis B.